LMPD Database

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LMP002551

UniProt Annotations

Entry Information
Gene Nameperoxisome proliferator activated receptor alpha
Protein EntryPPARA_MOUSE
UniProt IDP23204
SpeciesMouse
Comments
Comment typeDescription
Developmental StageIt appears first at 13.5 dpc and increases until birth.
DiseaseNote=Peroxisome proliferators are a diverse group of chemicals that include hypolipidaemic drugs, herbicides and industrial plasticisers. Administration of these chemicals to rodents results in the dramatic proliferation of hepatic peroxisomes as well as liver hyperplasia.
FunctionLigand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:12955147, ECO:0000269|PubMed:19646743, ECO:0000269|PubMed:20159955}.
InteractionO88559:Men1; NbExp=2; IntAct=EBI-5273083, EBI-3990176;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
SimilarityContains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:20159955}.
SubunitHeterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 AND ASXL2. Interacts with PER2. {ECO:0000269|PubMed:10788465, ECO:0000269|PubMed:16950137, ECO:0000269|PubMed:18719582, ECO:0000269|PubMed:20159955, ECO:0000269|PubMed:9325263, ECO:0000269|PubMed:9627117}.
Tissue SpecificityHighly expressed in liver, kidney and heart. Very weakly expressed in brain and testis.