LMPD Database

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LMP003729

UniProt Annotations

Entry Information
Gene Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Protein EntryHDBP1_HUMAN
UniProt IDQ8IV16
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity).
PolymorphismThe missense variant Arg-56 may be associated with severe hypertriglyceridemia and chylomicronemia.
PtmGlycosylation of Asn-78 is critical for cell surface localization and the binding of chylomicrons and lipoprotein lipase.
SimilarityContains 1 UPAR/Ly6 domain.
Subcellular LocationApical cell membrane ; Lipid- anchor, GPI-anchor . Basolateral cell membrane {ECO
SubunitBinds with high affinity to high-density lipoprotein (HDL) (By similarity). Binds to lipoprotein lipase (LPL), chylomicrons and APOA5.