LMPD Database

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LMP003790

UniProt Annotations

Entry Information
Gene Namedolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Protein EntryDPM2_HUMAN
UniProt IDO94777
SpeciesHuman
Comments
Comment typeDescription
DiseaseCongenital disorder of glycosylation 1U (CDG1U) [MIM
FunctionRegulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the DPM2 family.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitComponent of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex.
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=DPM2";