LMPD Database

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LMP005434

UniProt Annotations

Entry Information
Gene Namearylsulfatase G
Protein EntryARSG_HUMAN
UniProt IDQ96EG1
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=4.2 mM for p-nitrocatechol sulfate ; Vmax=63.5 umol/min/mg enzyme toward p-nitrocatechol sulfate ; pH dependence: Optimum pH is 5.4. ; Temperature dependence: Most efficient at 45-50 degrees Celsius. ;
CofactorName=Ca(2+); Xref=ChEBI
Enzyme RegulationInhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine.
FunctionDisplays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate.
PtmGlycosylated.
PtmN-glycosylated.
PtmThe conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Sequence CautionSequence=BAA76845.2; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the sulfatase family.
Subcellular LocationLysosome {ECO
Tissue SpecificityWidely expressed, with very low expression in brain, lung, heart and skeletal muscle.