LMPD Database

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LMP006686

Record overview

LMPD IDLMP006686
Gene ID22845
SpeciesHomo sapiens (Human)
Gene Namedolichol kinase
Gene SymbolDOLK
SynonymsCDG1M; DK; DK1; SEC59; TMEM15
Alternate namesdolichol kinase; SEC59 homolog; dolichol kinase 1; transmembrane protein 15
Chromosome9
Map Location9q34.11
EC Number2.7.1.108
SummaryThe protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
OrthologsView orthologs and multiple alignments for DOLK

Proteins

dolichol kinase
Refseq ID:NP_055723
Protein GI:7662482
UniProt ID:Q9UPQ8
mRNA ID:NM_014908
Length:538
RefSeq Status:REVIEWED
MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQ
TAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGG
ISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYL
LAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERD
SGPLILTHIYLLLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLN
YSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA