LMPD Database

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LMP006686

UniProt Annotations

Entry Information
Gene Namedolichol kinase
Protein EntryDOLK_HUMAN
UniProt IDQ9UPQ8
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCTP + dolichol = CDP + dolichyl phosphate.
DiseaseCongenital disorder of glycosylation 1M (CDG1M) [MIM
FunctionInvolved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.
MiscellaneousComplements the defects in growth, dolichol kinase activity and protein N-glycosylation at the restrictive temperature in yeast sec59 mutant cells.
Sequence CautionSequence=BAA83046.2; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the polyprenol kinase family.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Tissue SpecificityUbiquitous.