LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006729

UniProt Annotations

Entry Information
Gene Nameprostaglandin E receptor 3 (subtype EP3)
Protein EntryPE2R3_HUMAN
UniProt IDP43115
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=11; Comment=Additional isoforms seem to exist.; Name=EP3A; Synonyms=EP3-I, EP3a1, EP3a2, EP(3-Ic); IsoId=P43115-1; Sequence=Displayed; Name=EP3C; Synonyms=EP3-II; IsoId=P43115-2; Sequence=VSP_001935; Note=Known as EP3D in PubMed:8075855.; Name=EP3B; Synonyms=EP3-III; IsoId=P43115-3; Sequence=VSP_001936; Note=Known as EP3E in PubMed:8075855.; Name=EP3D; Synonyms=EP3-IV; IsoId=P43115-4; Sequence=VSP_001937; Note=Known as EP3F in PubMed:8075855.; Name=EP3E; IsoId=P43115-5; Sequence=VSP_001938; Name=EP3F; IsoId=P43115-6; Sequence=VSP_001939; Name=EP3G; IsoId=P43115-7; Sequence=VSP_013271; Name=EP3-III; IsoId=P43115-8; Sequence=VSP_053774; Name=EP3-IV; IsoId=P43115-9; Sequence=VSP_053775; Name=EP3-V; IsoId=P43115-10; Sequence=VSP_053776; Name=EP3E2; IsoId=P43115-11; Sequence=VSP_053777;
FunctionReceptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity). {ECO:0000250}.
Sequence CautionSequence=CAA58742.1; Type=Frameshift; Positions=374; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. {ECO:0000269|PubMed:18023986}.