LMPD Database

LMP006806

Gene Information

Entrez Gene ID	4035
Gene Name	low density lipoprotein receptor-related protein 1
Gene Symbol	LRP1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030136	IEA:Ensembl	C	clathrin-coated vesicle
GO:0005905	IEA:UniProtKB-KW	C	coated pit
GO:0030425	IEA:Ensembl	C	dendrite
GO:0030666	TAS:Reactome	C	endocytic vesicle membrane
GO:0005768	IEA:Ensembl	C	endosome
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0005887	ISS:UniProtKB	C	integral component of plasma membrane
GO:0005765	IDA:UniProtKB	C	lysosomal membrane
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0043235	IDA:MGI	C	receptor complex
GO:0034185	IDA:UniProtKB	F	apolipoprotein binding
GO:0005509	ISS:UniProtKB	F	calcium ion binding
GO:0070325	IC:BHF-UCL	F	lipoprotein particle receptor binding
GO:0042954	NAS:UniProtKB	F	lipoprotein transporter activity
GO:0044822	IDA:UniProtKB	F	poly(A) RNA binding
GO:0032403	IDA:BHF-UCL	F	protein complex binding
GO:0004872	TAS:ProtInc	F	receptor activity
GO:0007568	IEA:Ensembl	P	aging
GO:0035909	ISS:BHF-UCL	P	aorta morphogenesis
GO:0043277	ISS:BHF-UCL	P	apoptotic cell clearance
GO:0097242	TAS:BHF-UCL	P	beta-amyloid clearance
GO:0008283	IEA:Ensembl	P	cell proliferation
GO:0008203	IEA:Ensembl	P	cholesterol metabolic process
GO:0042157	IEA:Ensembl	P	lipoprotein metabolic process
GO:0042953	NAS:UniProtKB	P	lipoprotein transport
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:2000587	ISS:BHF-UCL	P	negative regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:0014912	ISS:BHF-UCL	P	negative regulation of smooth muscle cell migration
GO:0030178	ISS:BHF-UCL	P	negative regulation of Wnt signaling pathway
GO:0007603	TAS:Reactome	P	phototransduction, visible light
GO:0010875	ISS:BHF-UCL	P	positive regulation of cholesterol efflux
GO:0032370	ISS:BHF-UCL	P	positive regulation of lipid transport
GO:0051222	IEA:Ensembl	P	positive regulation of protein transport
GO:0007205	IEA:Ensembl	P	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0006898	IEA:Ensembl	P	receptor-mediated endocytosis
GO:0032956	ISS:BHF-UCL	P	regulation of actin cytoskeleton organization
GO:0032374	ISS:BHF-UCL	P	regulation of cholesterol transport
GO:0032429	ISS:BHF-UCL	P	regulation of phospholipase A2 activity
GO:0001523	TAS:Reactome	P	retinoid metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa05010	Alzheimer's disease
hsa05144	Malaria

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_160163	Scavenging of heme from plasma