LMPD Database

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LMP006806

UniProt Annotations

Entry Information
Gene Namelow density lipoprotein receptor-related protein 1
Protein EntryLRP1_HUMAN
UniProt IDQ07954
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q07954-1; Sequence=Displayed; Name=2; IsoId=Q07954-2; Sequence=VSP_056919, VSP_056920; Note=No experimental confirmation available;
FunctionEndocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
FunctionFunctions as a receptor for Pseudomonas aeruginosa exotoxin A.
InteractionO00213:APBB1; NbExp=3; IntAct=EBI-1046087, EBI-81694; Q15485:FCN2; NbExp=2; IntAct=EBI-1046087, EBI-7468784; Q63722:Jag1 (xeno); NbExp=4; IntAct=EBI-1046087, EBI-4567800; P11226:MBL2; NbExp=5; IntAct=EBI-1046087, EBI-5325353; Q03350:Thbs2 (xeno); NbExp=2; IntAct=EBI-1046087, EBI-4567830;
PtmCleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non- covalently associated. Gamma-secretase-dependent cleavage of LRP- 85 releases the intracellular domain from the membrane.
PtmPhosphorylated on serine and threonine residues.
PtmPhosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
PtmThe N-terminus is blocked.
SimilarityBelongs to the LDLR family.
SimilarityContains 22 EGF-like domains. {ECO
SimilarityContains 31 LDL-receptor class A domains.
SimilarityContains 34 LDL-receptor class B repeats.
Subcellular LocationLow-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.
Subcellular LocationLow-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.
Subcellular LocationLow-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
SubunitHeterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Can weakly interact (via NPXY motif) with DAB2 (via PID domain); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif. Interacts with bacterial exotoxins. {ECO
Tissue SpecificityMost abundant in liver, brain and lung.