LMPD Database

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LMP007131

UniProt Annotations

Entry Information
Gene Namepyruvate carboxylase 1
Protein EntryPYC1_YEAST
UniProt IDP11154
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.
CofactorName=biotin; Xref=ChEBI:CHEBI:57586; Note=Biotin.;
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105;
FunctionPyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
InteractionP39940:RSP5; NbExp=2; IntAct=EBI-14358, EBI-16219;
MiscellaneousPresent with 12500 molecules/cell in log phase SD medium
MiscellaneousPresent with 12500 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayCarbohydrate biosynthesis; gluconeogenesis.
SimilarityContains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
SimilarityContains 1 biotin carboxylation domain
SimilarityContains 1 biotin carboxylation domain. {ECO:0000305}.
SimilarityContains 1 biotinyl-binding domain
SimilarityContains 1 biotinyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
SimilarityContains 1 carboxyltransferase domain
SimilarityContains 1 carboxyltransferase domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomotetramer.