LMPD Database

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LMP012477

UniProt Annotations

Entry Information
Gene Nameestrogen receptor 2 (ER beta)
Protein EntryESR2_RAT
UniProt IDQ62986
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Beta1; IsoId=Q62986-1; Sequence=Displayed; Name=2; Synonyms=Beta2; IsoId=Q62986-2; Sequence=VSP_003699; Name=3; Synonyms=Beta1-delta3; IsoId=Q62986-3; Sequence=VSP_003697; Name=4; Synonyms=Beta2-delta3; IsoId=Q62986-4; Sequence=VSP_003697, VSP_003699; Name=5; Synonyms=Beta1-delta4; IsoId=Q62986-5; Sequence=VSP_003698;
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionBinds estrogens with an affinity similar to that of ER- alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER- alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.
PtmPhosphorylation at Ser-87 and Ser-105 recruits NCOA1
Sequence CautionSequence=CAA05631.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the nuclear hormone receptor family. NR3 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus.
SubunitBinds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1, UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with PRMT2 (By similarity). Interacts with DYX1C1. {ECO:0000250, ECO:0000269|PubMed:11818503, ECO:0000269|PubMed:19423554}.
Tissue SpecificityExpressed in prostate, ovary, lung, liver, kidney, fat, bone, brain, uterus and testis.