LMPD Database

LMP012541

Gene Information

Entrez Gene ID	25664
Gene Name	peroxisome proliferator-activated receptor gamma
Gene Symbol	Pparg
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	IDA:RGD	C	cytosol
GO:0005634	IDA:RGD	C	nucleus
GO:0048471	IDA:RGD	C	perinuclear region of cytoplasm
GO:0003682	ISS:UniProtKB	F	chromatin binding
GO:0003677	IDA:RGD	F	DNA binding
GO:0008144	IEA:Ensembl	F	drug binding
GO:0030331	IPI:RGD	F	estrogen receptor binding
GO:0004879	IEA:InterPro	F	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0030374	ISS:UniProtKB	F	ligand-dependent nuclear receptor transcription coactivator activity
GO:0019903	IDA:RGD	F	protein phosphatase binding
GO:0001012	IEA:Ensembl	F	RNA polymerase II regulatory region DNA binding
GO:0001228	IEA:Ensembl	F	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0043565	IEA:InterPro	F	sequence-specific DNA binding
GO:0003700	IDA:BHF-UCL	F	sequence-specific DNA binding transcription factor activity
GO:0003707	IEA:InterPro	F	steroid hormone receptor activity
GO:0008134	IPI:RGD	F	transcription factor binding
GO:0044212	IDA:BHF-UCL	F	transcription regulatory region DNA binding
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0006919	IEA:Ensembl	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050873	IEA:Ensembl	P	brown fat cell differentiation
GO:0045165	IEA:Ensembl	P	cell fate commitment
GO:0048469	IEA:Ensembl	P	cell maturation
GO:0071455	IEP:RGD	P	cellular response to hyperoxia
GO:0032869	IEA:Ensembl	P	cellular response to insulin stimulus
GO:0071285	IEA:Ensembl	P	cellular response to lithium ion
GO:0071380	IEP:RGD	P	cellular response to prostaglandin E stimulus
GO:0071379	IEP:RGD	P	cellular response to prostaglandin stimulus
GO:0071300	IEP:RGD	P	cellular response to retinoic acid
GO:0071306	IEP:RGD	P	cellular response to vitamin E
GO:0030855	IEA:Ensembl	P	epithelial cell differentiation
GO:0006631	TAS:RGD	P	fatty acid metabolic process
GO:0019395	IMP:RGD	P	fatty acid oxidation
GO:0042593	IEA:Ensembl	P	glucose homeostasis
GO:0007507	IEP:RGD	P	heart development
GO:0042953	IEA:Ensembl	P	lipoprotein transport
GO:0015909	IEA:Ensembl	P	long-chain fatty acid transport
GO:0045713	IEA:Ensembl	P	low-density lipoprotein particle receptor biosynthetic process
GO:0030224	IEA:Ensembl	P	monocyte differentiation
GO:0002674	IMP:RGD	P	negative regulation of acute inflammatory response
GO:0030308	IMP:RGD	P	negative regulation of cell growth
GO:0008285	IMP:RGD	P	negative regulation of cell proliferation
GO:0010887	IEA:Ensembl	P	negative regulation of cholesterol storage
GO:0032966	IMP:RGD	P	negative regulation of collagen biosynthetic process
GO:0060336	IEA:Ensembl	P	negative regulation of interferon-gamma-mediated signaling pathway
GO:2000230	IMP:RGD	P	negative regulation of pancreatic stellate cell proliferation
GO:0010871	IEA:Ensembl	P	negative regulation of receptor biosynthetic process
GO:0010891	IEA:Ensembl	P	negative regulation of sequestering of triglyceride
GO:0048662	IEA:Ensembl	P	negative regulation of smooth muscle cell proliferation
GO:0051974	IMP:RGD	P	negative regulation of telomerase activity
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0031100	IEP:RGD	P	organ regeneration
GO:0035357	IEA:Ensembl	P	peroxisome proliferator activated receptor signaling pathway
GO:0001890	IEA:Ensembl	P	placenta development
GO:0043065	IMP:RGD	P	positive regulation of apoptotic process
GO:0045600	ISS:HGNC	P	positive regulation of fat cell differentiation
GO:0046321	IMP:RGD	P	positive regulation of fatty acid oxidation
GO:0048714	IMP:RGD	P	positive regulation of oligodendrocyte differentiation
GO:0060100	IMP:RGD	P	positive regulation of phagocytosis, engulfment
GO:0051091	IEA:Ensembl	P	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045893	ISS:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:0045944	IDA:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:0008217	IEA:Ensembl	P	regulation of blood pressure
GO:0045598	IDA:RGD	P	regulation of fat cell differentiation
GO:0019216	IMP:RGD	P	regulation of lipid metabolic process
GO:0006357	IMP:RGD	P	regulation of transcription from RNA polymerase II promoter
GO:0060850	ISS:UniProtKB	P	regulation of transcription involved in cell fate commitment
GO:0031000	IEP:RGD	P	response to caffeine
GO:0009409	IEP:RGD	P	response to cold
GO:0036270	IEP:RGD	P	response to diuretic
GO:0042493	IEP:RGD	P	response to drug
GO:0043627	IEP:RGD	P	response to estrogen
GO:0035902	IEP:RGD	P	response to immobilization stress
GO:0033993	IEP:RGD	P	response to lipid
GO:0055098	IEA:Ensembl	P	response to low-density lipoprotein particle
GO:0009612	IEP:RGD	P	response to mechanical stimulus
GO:1901558	IEP:RGD	P	response to metformin
GO:0014070	IEP:RGD	P	response to organic cyclic compound
GO:0010033	IEP:RGD	P	response to organic substance
GO:0032526	ISS:UniProtKB	P	response to retinoic acid
GO:0042594	IEP:RGD	P	response to starvation
GO:0033189	IEP:RGD	P	response to vitamin A
GO:0050872	ISS:HGNC	P	white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID	Description
ko04152	AMPK signaling pathway
rno04152	AMPK signaling pathway
ko05016	Huntington's disease
rno05016	Huntington's disease
ko04380	Osteoclast differentiation
rno04380	Osteoclast differentiation
rno05200	Pathways in cancer
ko03320	PPAR signaling pathway
rno03320	PPAR signaling pathway
ko05216	Thyroid cancer
rno05216	Thyroid cancer
ko05202	Transcriptional misregulation in cancer
rno05202	Transcriptional misregulation in cancer

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953533	Developmental Biology
5953288	Fatty acid, triacylglycerol, and ketone body metabolism
5953330	Gene Expression
5953833	Generic Transcription Pathway
5953250	Metabolism
5953289	Metabolism of lipids and lipoproteins
5954147	Nuclear Receptor transcription pathway
5954333	PPARA activates gene expression
5954222	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5954166	Transcriptional regulation of white adipocyte differentiation