LMPD Database

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LMP012541

UniProt Annotations

Entry Information
Gene Nameperoxisome proliferator-activated receptor gamma
Protein EntryPPARG_RAT
UniProt IDO88275
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=2; IsoId=O88275-1; Sequence=Displayed; Name=1; IsoId=O88275-2; Sequence=VSP_003649;
Enzyme RegulationPDPK1 activates its transcriptional activity independently of its kinase activity
FunctionNuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses (By similarity)
PtmO-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes
PtmPhosphorylated at basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at induces adipogenic activity (By similarity)
PtmPhosphorylated by MAPK. The phosphorylation inhibits PPAR gamma activity. {ECO:0000269|PubMed:8943212, ECO:0000269|PubMed:8953045, ECO:0000269|PubMed:9030579}.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Cytoplasm . Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation (By similarity)
SubunitHeterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with CCRN4L/NOC. Interacts with FOXO1 (acetylated form) (By similarity)
Tissue SpecificityHighest expression in adipose tissue.