LMPD Database

LMP012553

Gene Information

Entrez Gene ID	25728
Gene Name	apolipoprotein E
Gene Symbol	Apoe
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0072562	IEA:Ensembl	C	blood microparticle
GO:0009986	IDA:RGD	C	cell surface
GO:0042627	IEA:UniProtKB-KW	C	chylomicron
GO:0005737	IDA:RGD	C	cytoplasm
GO:0030425	IDA:RGD	C	dendrite
GO:0034365	IDA:RGD	C	discoidal high-density lipoprotein particle
GO:0005783	IDA:RGD	C	endoplasmic reticulum
GO:0005768	IDA:RGD	C	endosome
GO:0005615	IDA:RGD	C	extracellular space
GO:0070062	IEA:Ensembl	C	extracellular vesicular exosome
GO:0031232	IDA:RGD	C	extrinsic component of external side of plasma membrane
GO:0005794	IDA:RGD	C	Golgi apparatus
GO:0034363	IEA:Ensembl	C	intermediate-density lipoprotein particle
GO:0005770	IDA:RGD	C	late endosome
GO:0005764	IDA:RGD	C	lysosome
GO:0043025	IDA:RGD	C	neuronal cell body
GO:0005635	IDA:RGD	C	nuclear envelope
GO:0005886	IDA:RGD	C	plasma membrane
GO:0034361	IEA:UniProtKB-KW	C	very-low-density lipoprotein particle
GO:0016209	IEA:Ensembl	F	antioxidant activity
GO:0001540	ISS:UniProtKB	F	beta-amyloid binding
GO:0017127	IEA:Ensembl	F	cholesterol transporter activity
GO:0008201	IEA:UniProtKB-KW	F	heparin binding
GO:0046848	IDA:RGD	F	hydroxyapatite binding
GO:0005319	IDA:RGD	F	lipid transporter activity
GO:0071813	IEA:Ensembl	F	lipoprotein particle binding
GO:0046911	IEA:Ensembl	F	metal chelating activity
GO:0005543	IDA:RGD	F	phospholipid binding
GO:0005102	IPI:UniProt	F	receptor binding
GO:0007568	IDA:RGD	P	aging
GO:0097113	IEA:Ensembl	P	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0048844	IEA:Ensembl	P	artery morphogenesis
GO:0006874	IEA:Ensembl	P	cellular calcium ion homeostasis
GO:0071397	IEP:RGD	P	cellular response to cholesterol
GO:0071363	IEP:RGD	P	cellular response to growth factor stimulus
GO:0071347	IEP:RGD	P	cellular response to interleukin-1
GO:0019934	IEA:Ensembl	P	cGMP-mediated signaling
GO:0006707	IEA:Ensembl	P	cholesterol catabolic process
GO:0033344	IEA:Ensembl	P	cholesterol efflux
GO:0042632	IEA:Ensembl	P	cholesterol homeostasis
GO:0034382	IEA:Ensembl	P	chylomicron remnant clearance
GO:0055089	IEA:Ensembl	P	fatty acid homeostasis
GO:0007186	IEA:Ensembl	P	G-protein coupled receptor signaling pathway
GO:0034380	IEA:Ensembl	P	high-density lipoprotein particle assembly
GO:0034384	IEA:Ensembl	P	high-density lipoprotein particle clearance
GO:0034375	IEA:Ensembl	P	high-density lipoprotein particle remodeling
GO:0006869	IDA:RGD	P	lipid transport
GO:0042158	IEA:Ensembl	P	lipoprotein biosynthetic process
GO:0042159	IEA:Ensembl	P	lipoprotein catabolic process
GO:0042157	IDA:RGD	P	lipoprotein metabolic process
GO:0015909	IEA:Ensembl	P	long-chain fatty acid transport
GO:0034374	IEA:Ensembl	P	low-density lipoprotein particle remodeling
GO:0051651	IEA:Ensembl	P	maintenance of location in cell
GO:1902430	IEA:Ensembl	P	negative regulation of beta-amyloid formation
GO:0043537	IEA:Ensembl	P	negative regulation of blood vessel endothelial cell migration
GO:0045541	IEA:Ensembl	P	negative regulation of cholesterol biosynthetic process
GO:0090370	IEA:Ensembl	P	negative regulation of cholesterol efflux
GO:0061000	IEA:Ensembl	P	negative regulation of dendritic spine development
GO:1902951	IEA:Ensembl	P	negative regulation of dendritic spine maintenance
GO:0001937	IEA:Ensembl	P	negative regulation of endothelial cell proliferation
GO:0050728	IEA:Ensembl	P	negative regulation of inflammatory response
GO:1903001	IEA:Ensembl	P	negative regulation of lipid transport across blood brain barrier
GO:0043407	IEA:Ensembl	P	negative regulation of MAP kinase activity
GO:0043524	IDA:RGD	P	negative regulation of neuron apoptotic process
GO:1902999	IEA:Ensembl	P	negative regulation of phospholipid efflux
GO:0010544	IEA:Ensembl	P	negative regulation of platelet activation
GO:1901627	IEA:Ensembl	P	negative regulation of postsynaptic membrane organization
GO:1901630	IEA:Ensembl	P	negative regulation of presynaptic membrane organization
GO:0031102	TAS:RGD	P	neuron projection regeneration
GO:0007263	IEA:Ensembl	P	nitric oxide mediated signal transduction
GO:0097114	IEA:Ensembl	P	N-methyl-D-aspartate receptor clustering
GO:0048709	IEP:RGD	P	oligodendrocyte differentiation
GO:0014012	IEP:RGD	P	peripheral nervous system axon regeneration
GO:0033700	IEA:Ensembl	P	phospholipid efflux
GO:0045773	IDA:RGD	P	positive regulation of axon extension
GO:1902004	IEA:Ensembl	P	positive regulation of beta-amyloid formation
GO:0030828	IEA:Ensembl	P	positive regulation of cGMP biosynthetic process
GO:0010875	IEA:Ensembl	P	positive regulation of cholesterol efflux
GO:0060999	IEA:Ensembl	P	positive regulation of dendritic spine development
GO:1902952	IEA:Ensembl	P	positive regulation of dendritic spine maintenance
GO:0046889	IEA:Ensembl	P	positive regulation of lipid biosynthetic process
GO:1903002	IEA:Ensembl	P	positive regulation of lipid transport across blood brain barrier
GO:0032805	IEA:Ensembl	P	positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0051044	IEA:Ensembl	P	positive regulation of membrane protein ectodomain proteolysis
GO:1902998	IEA:Ensembl	P	positive regulation of neurofibrillary tangle assembly
GO:1901216	IEA:Ensembl	P	positive regulation of neuron death
GO:0051000	IEA:Ensembl	P	positive regulation of nitric-oxide synthase activity
GO:1902995	IEA:Ensembl	P	positive regulation of phospholipid efflux
GO:1901628	IEA:Ensembl	P	positive regulation of postsynaptic membrane organization
GO:1901631	IEA:Ensembl	P	positive regulation of presynaptic membrane organization
GO:0017038	IEA:Ensembl	P	protein import
GO:0006898	IEA:Ensembl	P	receptor-mediated endocytosis
GO:1900221	IEA:Ensembl	P	regulation of beta-amyloid clearance
GO:0032489	IEA:Ensembl	P	regulation of Cdc42 protein signal transduction
GO:1902947	IEA:Ensembl	P	regulation of tau-protein kinase activity
GO:0002021	IEA:Ensembl	P	response to dietary excess
GO:0045471	IEP:RGD	P	response to ethanol
GO:0032868	IEP:RGD	P	response to insulin
GO:0006979	IEA:Ensembl	P	response to oxidative stress
GO:0032526	IEP:RGD	P	response to retinoic acid
GO:0043691	IEA:Ensembl	P	reverse cholesterol transport
GO:0006641	IEA:Ensembl	P	triglyceride metabolic process
GO:0042311	IEA:Ensembl	P	vasodilation
GO:0034447	IEA:Ensembl	P	very-low-density lipoprotein particle clearance

KEGG Pathway Links

KEGG Pathway ID	Description
ko05010	Alzheimer's disease
rno05010	Alzheimer's disease

REACTOME Pathway Links

REACTOME Pathway ID	Description
5954562	Binding and Uptake of Ligands by Scavenger Receptors
5953879	Chylomicron-mediated lipid transport
5953253	Disease
5953382	Diseases associated with visual transduction
5954088	HDL-mediated lipid transport
5953754	Lipid digestion, mobilization, and transport
5953836	Lipoprotein metabolism
5953250	Metabolism
5953289	Metabolism of lipids and lipoproteins
5954392	Retinoid metabolism and transport
5954564	Scavenging by Class A Receptors
5953381	Signal Transduction
5953380	Visual phototransduction