LMPD Database

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LMP012553

UniProt Annotations

Entry Information
Gene Nameapolipoprotein E
Protein EntryAPOE_RAT
UniProt IDP02650
SpeciesRat
Comments
Comment typeDescription
FunctionMediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
MiscellaneousThe mature protein has no cysteine residues; however, in different allelic variants where cysteine residues replace arginine at positions 155 or 168, binding of Apo-E to cell membrane receptors is decreased. The amino end of this protein is therefore thought to interact with the receptor.
PtmPhosphorylation sites are present in the extracellular medium
SimilarityBelongs to the apolipoprotein A1/A4/E family
Subcellular LocationSecreted.
Tissue SpecificitySecreted in plasma.