LMPD Database

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LMP012557

Gene Information

Entrez Gene ID25747
Gene Nameperoxisome proliferator activated receptor alpha
Gene SymbolPpara
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005634 IDA:RGDCnucleus
GO:0008144 ISS:UniProtKBFdrug binding
GO:0004879 IMP:RGDFligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008289 ISS:UniProtKBFlipid binding
GO:0097371 IPI:RGDFMDM2/MDM4 family protein binding
GO:0051525 IPI:RGDFNFAT protein binding
GO:0019902 IPI:RGDFphosphatase binding
GO:0032403 IMP:RGDFprotein complex binding
GO:0019904 IDA:RGDFprotein domain specific binding
GO:0000978 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001077 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190 IEA:EnsemblFRNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003707 TAS:RGDFsteroid hormone receptor activity
GO:0008270 IEA:InterProFzinc ion binding
GO:0035095 IDA:RGDPbehavioral response to nicotine
GO:0032922 ISS:UniProtKBPcircadian regulation of gene expression
GO:0070166 IEA:EnsemblPenamel mineralization
GO:0008544 IEA:EnsemblPepidermis development
GO:0006631 IMP:RGDPfatty acid metabolic process
GO:0007507 IEP:RGDPheart development
GO:0030522 IMP:GOCPintracellular receptor signaling pathway
GO:0042157 IMP:RGDPlipoprotein metabolic process
GO:0032099 ISS:UniProtKBPnegative regulation of appetite
GO:0045776 IMP:RGDPnegative regulation of blood pressure
GO:0010887 IEA:EnsemblPnegative regulation of cholesterol storage
GO:1901215 IDA:RGDPnegative regulation of neuron death
GO:0032091 IMP:RGDPnegative regulation of protein binding
GO:0010871 IEA:EnsemblPnegative regulation of receptor biosynthetic process
GO:0010891 IEA:EnsemblPnegative regulation of sequestering of triglyceride
GO:2000678 IMP:RGDPnegative regulation of transcription regulatory region DNA binding
GO:0046321 IEA:EnsemblPpositive regulation of fatty acid oxidation
GO:0045722 IEA:EnsemblPpositive regulation of gluconeogenesis
GO:0045893 ISS:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0072366 IEA:EnsemblPregulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752 ISS:UniProtKBPregulation of circadian rhythm
GO:0019217 TAS:RGDPregulation of fatty acid metabolic process
GO:0072363 IEA:EnsemblPregulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter
GO:0072369 IEA:EnsemblPregulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0006355 IDA:RGDPregulation of transcription, DNA-templated
GO:0001666 IDA:HGNCPresponse to hypoxia
GO:0032868 IMP:RGDPresponse to insulin
GO:0042060 IEA:EnsemblPwound healing
KEGG Pathway Links
KEGG Pathway IDDescription
ko04920Adipocytokine signaling pathway
rno04920Adipocytokine signaling pathway
ko04024cAMP signaling pathway
rno04024cAMP signaling pathway
ko05160Hepatitis C
rno05160Hepatitis C
ko04932Non-alcoholic fatty liver disease (NAFLD)
rno04932Non-alcoholic fatty liver disease (NAFLD)
ko03320PPAR signaling pathway
rno03320PPAR signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
5954496Activation of gene expression by SREBF (SREBP)
5954332BMAL1:CLOCK,NPAS2 activates circadian gene expression
5954223Circadian Clock
5953533Developmental Biology
5953288Fatty acid, triacylglycerol, and ketone body metabolism
5953330Gene Expression
5953833Generic Transcription Pathway
5953250Metabolism
5953289Metabolism of lipids and lipoproteins
5953600Mitochondrial biogenesis
5954147Nuclear Receptor transcription pathway
5953601Organelle biogenesis and maintenance
5954333PPARA activates gene expression
5954497Regulation of cholesterol biosynthesis by SREBP (SREBF)
5954222Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5954224REV-ERBA represses gene expression
5954225RORA activates circadian gene expression
5953599Transcriptional activation of mitochondrial biogenesis
5954166Transcriptional regulation of white adipocyte differentiation
5954528YAP1- and WWTR1 (TAZ)-stimulated gene expression