LMPD Database

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LMP012557

UniProt Annotations

Entry Information
Gene Nameperoxisome proliferator activated receptor alpha
Protein EntryPPARA_RAT
UniProt IDP37230
SpeciesRat
Comments
Comment typeDescription
FunctionLigand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity)
PtmPhosphorylated
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus.
SubunitHeterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 AND ASXL2. Interacts with PER2 (By similarity)
Tissue SpecificityExpressed predominantly in liver and kidney.