LMPD Database

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LMP012627

UniProt Annotations

Entry Information
Gene Namebranched chain keto acid dehydrogenase E1, beta polypeptide
Protein EntryODBB_RAT
UniProt IDP35738
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2- methylpropanoyl)transferase] S-(2- methylpropanoyl)dihydrolipoyllysine + CO(2).
FunctionThe branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Sequence CautionSequence=AAA73899.1; Type=Frameshift; Positions=101, 120; Evidence= ; Sequence=AAA73899.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence= ;
Subcellular LocationMitochondrion matrix.
SubunitHeterotetramer of 2 alpha and 2 beta chains