LMPD Database

LMP012674

Gene Information

Entrez Gene ID	60351
Gene Name	nuclear receptor subfamily 1, group H, member 4
Gene Symbol	Nr1h4
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005719	IEA:Ensembl	C	nuclear euchromatin
GO:0005634	IDA:RGD	C	nucleus
GO:0032052	IPI:UniProtKB	F	bile acid binding
GO:0038181	IDA:UniProtKB	F	bile acid receptor activity
GO:1902122	IEA:Ensembl	F	chenodeoxycholic acid binding
GO:0003677	IDA:RGD	F	DNA binding
GO:0042277	IDA:RGD	F	peptide binding
GO:0004872	IDA:RGD	F	receptor activity
GO:0000978	IDA:NTNU_SB	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	IDA:NTNU_SB	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000980	IEA:Ensembl	F	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003705	IEA:Ensembl	F	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0001190	IEA:Ensembl	F	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003707	IDA:RGD	F	steroid hormone receptor activity
GO:0004887	IEA:InterPro	F	thyroid hormone receptor activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0008206	IDA:RGD	P	bile acid metabolic process
GO:0071229	IEA:Ensembl	P	cellular response to acid chemical
GO:0071417	IEA:Ensembl	P	cellular response to organonitrogen compound
GO:0048565	IEP:RGD	P	digestive tract development
GO:0038185	IEA:Ensembl	P	intracellular bile acid receptor signaling pathway
GO:0070858	IEA:Ensembl	P	negative regulation of bile acid biosynthetic process
GO:0000122	IMP:RGD	P	negative regulation of transcription from RNA polymerase II promoter
GO:2001250	IEA:Ensembl	P	positive regulation of ammonia assimilation cycle
GO:0045944	IDA:NTNU_SB	P	positive regulation of transcription from RNA polymerase II promoter
GO:0006109	IMP:RGD	P	regulation of carbohydrate metabolic process
GO:0034255	IEA:Ensembl	P	regulation of urea metabolic process
GO:0009749	IEP:RGD	P	response to glucose
GO:0032496	IEP:RGD	P	response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID	Description
ko04976	Bile secretion
rno04976	Bile secretion

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953720	Bile acid and bile salt metabolism
5953258	Biological oxidations
5953485	Cytochrome P450 - arranged by substrate type
5953932	Endogenous sterols
5953288	Fatty acid, triacylglycerol, and ketone body metabolism
5953330	Gene Expression
5953833	Generic Transcription Pathway
5953250	Metabolism
5953289	Metabolism of lipids and lipoproteins
5954147	Nuclear Receptor transcription pathway
5953326	Phase 1 - Functionalization of compounds
5954333	PPARA activates gene expression
5953719	Recycling of bile acids and salts
5954222	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5953930	Synthesis of bile acids and bile salts
5953929	Synthesis of bile acids and bile salts via 27-hydroxycholesterol
5953931	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol