LMPD Database

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LMP012674

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group H, member 4
Protein EntryNR1H4_RAT
UniProt IDQ62735
SpeciesRat
Comments
Comment typeDescription
FunctionLigand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity)
InductionHeterodimer of NR1H4 and RXR activated by farnesol
PtmMethylation may increase transactivation of target genes
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily
SimilarityContains 1 nuclear receptor DNA-binding domain
Subcellular LocationNucleus .
SubunitInteracts with CARM1 and SMARD1. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2 (By similarity). Heterodimer of NR1H4 and RXR. {ECO:0000250, ECO:0000269|PubMed:7774010}.