LMPD Database

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LMP012924

Gene Information

Entrez Gene ID170897
Gene Namesphingosine kinase 1
Gene SymbolSphk1
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IDA:RGDCaxon
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005829 IDA:RGDCcytosol
GO:0043005 IDA:RGDCneuron projection
GO:0005634 IEA:UniProtKB-KWCnucleus
GO:0005886 IDA:RGDCplasma membrane
GO:0008021 IDA:RGDCsynaptic vesicle
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0017050 ISS:UniProtKBFD-erythro-sphingosine kinase activity
GO:0004143 IEA:InterProFdiacylglycerol kinase activity
GO:0003677 IEA:EnsemblFDNA binding
GO:0000287 ISS:UniProtKBFmagnesium ion binding
GO:0003951 IEA:InterProFNAD+ kinase activity
GO:0008481 IEA:UniProtKB-ECFsphinganine kinase activity
GO:0001568 IEA:EnsemblPblood vessel development
GO:0007420 IEA:EnsemblPbrain development
GO:0019722 IEA:EnsemblPcalcium-mediated signaling
GO:0071363 IEP:RGDPcellular response to growth factor stimulus
GO:0070301 IEP:RGDPcellular response to hydrogen peroxide
GO:0009267 IEP:RGDPcellular response to starvation
GO:0019371 IDA:RGDPcyclooxygenase pathway
GO:0007565 IEP:RGDPfemale pregnancy
GO:0006954 IEA:EnsemblPinflammatory response
GO:0043066 IMP:RGDPnegative regulation of apoptotic process
GO:0045766 IEA:EnsemblPpositive regulation of angiogenesis
GO:0030307 IEA:EnsemblPpositive regulation of cell growth
GO:0030335 IMP:RGDPpositive regulation of cell migration
GO:0048146 IEA:EnsemblPpositive regulation of fibroblast proliferation
GO:0045931 IEA:EnsemblPpositive regulation of mitotic cell cycle
GO:0010976 IMP:RGDPpositive regulation of neuron projection development
GO:0001956 IMP:RGDPpositive regulation of neurotransmitter secretion
GO:0042346 ISS:UniProtKBPpositive regulation of NF-kappaB import into nucleus
GO:0051092 ISS:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0001934 IMP:RGDPpositive regulation of protein phosphorylation
GO:0031398 ISS:UniProtKBPpositive regulation of protein ubiquitination
GO:0045987 IEA:EnsemblPpositive regulation of smooth muscle contraction
GO:0007205 IEA:InterProPprotein kinase C-activating G-protein coupled receptor signaling pathway
GO:0032651 IEA:EnsemblPregulation of interleukin-1 beta production
GO:0010803 ISS:UniProtKBPregulation of tumor necrosis factor-mediated signaling pathway
GO:0014075 IEP:RGDPresponse to amine
GO:0033198 IEP:RGDPresponse to ATP
GO:0070555 IEP:RGDPresponse to interleukin-1
GO:0032026 IEP:RGDPresponse to magnesium ion
GO:0014070 IEP:RGDPresponse to organic cyclic compound
GO:0032570 IEP:RGDPresponse to progesterone
GO:0006670 ISS:UniProtKBPsphingosine metabolic process
KEGG Pathway Links
KEGG Pathway IDDescription
ko04020Calcium signaling pathway
rno04020Calcium signaling pathway
ko04666Fc gamma R-mediated phagocytosis
rno04666Fc gamma R-mediated phagocytosis
rno01100Metabolic pathways
ko00600Sphingolipid metabolism
rno00600Sphingolipid metabolism
M00100Sphingosine degradation
ko05152Tuberculosis
rno05152Tuberculosis
ko04370VEGF signaling pathway
rno04370VEGF signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
5954190Association of TriC/CCT with target proteins during biosynthesis
5954184Chaperonin-mediated protein folding
5953250Metabolism
5953289Metabolism of lipids and lipoproteins
5953345Metabolism of proteins
5954185Protein folding
5953420Signaling by VEGF
5953381Signal Transduction
5954266Sphingolipid de novo biosynthesis
5954267Sphingolipid metabolism
5953419VEGFA-VEGFR2 Pathway
5953418VEGFR2 mediated cell proliferation