LMPD Database

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LMP012924

UniProt Annotations

Entry Information
Gene Namesphingosine kinase 1
Protein EntrySPHK1_RAT
UniProt IDQ91V26
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + sphinganine = ADP + sphinganine 1- phosphate.
Catalytic ActivityATP + sphingosine = ADP + sphingosine 1- phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
FunctionCatalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (By similarity)
MiscellaneousSphingosine 1-phosphate stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular LocationCytoplasm . Nucleus . Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner
SubunitInteracts with CIB1, the interaction occurs in a calcium- dependent manner (By similarity). Binds to calmodulin. Interacts with SPHKAP. Interacts with ACY1