LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP013208

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 27, subfamily a, polypeptide 1
Protein EntryCP27A_RAT
UniProt IDP17178
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity5-beta-cholestane-3-alpha,7-alpha,12-alpha- triol + 3 NADPH + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha- trihydroxy-5-beta-cholestan-26-oate + 3 NADP(+) + 4 H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
FunctionCatalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity.
PathwayHormone biosynthesis; cholecalciferol biosynthesis.
Sequence CautionSequence=AAA86314.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the cytochrome P450 family
Subcellular LocationMitochondrion membrane.
Tissue SpecificityExpressed in liver, hepatoma, kidney, ovary and epithelial cells of blood vessels.