LMPD Database

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LMP013314

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-4-phosphate 5-kinase, type I, beta
Protein EntryPI51B_RAT
UniProt IDQ5CZZ9
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
CautionThere is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha
FunctionParticipates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity)
SimilarityContains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular LocationEndomembrane system . Note=Associated with membranes
SubunitInteracts with RAC1, AJUBA, PLD1, PLD2 and ARF1