LMPD Database

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LMP001124

UniProt Annotations

Entry Information
Gene Nameestrogen-related receptor alpha
Protein EntryERR1_HUMAN
UniProt IDP11474
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11474-1; Sequence=Displayed; Name=2; IsoId=P11474-2; Sequence=VSP_035756; Note=No experimental confirmation available.;
FunctionBinds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. {ECO
InductionInduced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.
InteractionQ9Y4A5:TRRAP; NbExp=3; IntAct=EBI-372412, EBI-399128;
PtmPhosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. {ECO
PtmReversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
PtmSumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding. {ECO
Sequence CautionSequence=AAB17015.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA35778.1; Type=Frameshift; Positions=345, 354; Evidence= ;
SimilarityBelongs to the nuclear hormone receptor family. NR3 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus {ECO
SubunitBinds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation. {ECO
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ESRRAID44408ch11q13.html";