LMPD Database

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LMP006591

Record overview

LMPD IDLMP006591
Gene ID20698
SpeciesMus musculus(Mouse)
Gene Namesphingosine kinase 1
Gene SymbolSphk1
Synonyms1110006G24Rik; Sk1; Spk1
Alternate namessphingosine kinase 1; SK 1; SPK 1
Chromosome11
Map Location11 E2|11
EC Number2.7.1.91
SummaryThis gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
OrthologsView orthologs and multiple alignments for Sphk1

Proteins

sphingosine kinase 1 isoform 1 precursor
Refseq ID:NP_035581
Protein GI:22094105
UniProt ID:Q8CI15
mRNA ID:NM_011451
Length:388
RefSeq Status:REVIEWED
MWWCCVLFVVECPRGLLPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMER
PDWETAIQKPLCSLPGGSGNALAASVNHYAGYEQVTNEDLLINCTLLLCRRRLSPMNLLSLHTASGLRLYSVLSLSWGFVADVDLESEKYRRLGEIRFTV
GTFFRLASLRIYQGQLAYLPVGTVASKRPASTLVQKGPVDTHLVPLEEPVPSHWTVVPEQDFVLVLVLLHTHLSSELFAAPMGRCEAGVMHLFYVRAGVS
RAALLRLFLAMQKGKHMELDCPYLVHVPVVAFRLEPRSQRGVFSVDGELMVCEAVQGQVHPNYLWMVCGSRDAPSGRDSRRGPPPEEP
 
sphingosine kinase 1 isoform 2
Refseq ID:NP_079643
Protein GI:27532969
UniProt ID:Q8CI15
mRNA ID:NM_025367
Length:382
RefSeq Status:REVIEWED
MEPVECPRGLLPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWETA
IQKPLCSLPGGSGNALAASVNHYAGYEQVTNEDLLINCTLLLCRRRLSPMNLLSLHTASGLRLYSVLSLSWGFVADVDLESEKYRRLGEIRFTVGTFFRL
ASLRIYQGQLAYLPVGTVASKRPASTLVQKGPVDTHLVPLEEPVPSHWTVVPEQDFVLVLVLLHTHLSSELFAAPMGRCEAGVMHLFYVRAGVSRAALLR
LFLAMQKGKHMELDCPYLVHVPVVAFRLEPRSQRGVFSVDGELMVCEAVQGQVHPNYLWMVCGSRDAPSGRDSRRGPPPEEP
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2152
peptide sequence: 
MWWCCVLFVVECPRGLLP
 
sphingosine kinase 1 isoform 2
Refseq ID:NP_001165943
Protein GI:289191342
UniProt ID:Q8CI15
mRNA ID:NM_001172472
Length:382
RefSeq Status:REVIEWED
Protein sequence is identical to GI:27532969 (mRNA isoform)
 
sphingosine kinase 1 isoform 2
Refseq ID:NP_001165944
Protein GI:289191344
UniProt ID:Q8CI15
mRNA ID:NM_001172473
Length:382
RefSeq Status:REVIEWED
Protein sequence is identical to GI:27532969 (mRNA isoform)
 
sphingosine kinase 1 isoform 3
Refseq ID:NP_001165946
Protein GI:289191346
UniProt ID:Q8CI15
mRNA ID:NM_001172475
Length:381
RefSeq Status:REVIEWED
MEPECPRGLLPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWETAI
QKPLCSLPGGSGNALAASVNHYAGYEQVTNEDLLINCTLLLCRRRLSPMNLLSLHTASGLRLYSVLSLSWGFVADVDLESEKYRRLGEIRFTVGTFFRLA
SLRIYQGQLAYLPVGTVASKRPASTLVQKGPVDTHLVPLEEPVPSHWTVVPEQDFVLVLVLLHTHLSSELFAAPMGRCEAGVMHLFYVRAGVSRAALLRL
FLAMQKGKHMELDCPYLVHVPVVAFRLEPRSQRGVFSVDGELMVCEAVQGQVHPNYLWMVCGSRDAPSGRDSRRGPPPEEP