LMPD Database

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LMP006591

UniProt Annotations

Entry Information
Gene Namesphingosine kinase 1
Protein EntrySPHK1_MOUSE
UniProt IDQ8CI15
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8CI15-1; Sequence=Displayed; Name=2; IsoId=Q8CI15-2; Sequence=VSP_033448; Name=3; IsoId=Q8CI15-3; Sequence=VSP_033449;
Catalytic ActivityATP + sphinganine = ADP + sphinganine 1- phosphate.
Catalytic ActivityATP + sphingosine = ADP + sphingosine 1- phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionCatalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (By similarity). {ECO:0000250}.
MiscellaneousSphingosine 1-phosphate stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling. {ECO:0000250}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular LocationCytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner. {ECO:0000250}.
SubunitBinds to calmodulin. Interacts with SPHKAP. Interacts with CIB1, the interaction occurs in a calcium-dependent manner (By similarity). Interacts with ACY1. {ECO:0000250, ECO:0000269|PubMed:15196915}.