LMPD Database

LMP006591

Gene Information

Entrez Gene ID	20698
Gene Name	sphingosine kinase 1
Gene Symbol	Sphk1
Species	Mus musculus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030424	IEA:Ensembl	C	axon
GO:0005737	ISS:UniProtKB	C	cytoplasm
GO:0005829	IEA:Ensembl	C	cytosol
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0005886	ISS:UniProtKB	C	plasma membrane
GO:0008021	IEA:Ensembl	C	synaptic vesicle
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0005516	ISA:MGI	F	calmodulin binding
GO:0017050	ISS:UniProtKB	F	D-erythro-sphingosine kinase activity
GO:0004143	IEA:InterPro	F	diacylglycerol kinase activity
GO:0003677	ISA:MGI	F	DNA binding
GO:0000287	ISS:UniProtKB	F	magnesium ion binding
GO:0003951	IEA:InterPro	F	NAD+ kinase activity
GO:0008481	ISA:MGI	F	sphinganine kinase activity
GO:0001568	IGI:MGI	P	blood vessel development
GO:0007420	IGI:MGI	P	brain development
GO:0019722	IEA:Ensembl	P	calcium-mediated signaling
GO:0071363	IEA:Ensembl	P	cellular response to growth factor stimulus
GO:0070301	IEA:Ensembl	P	cellular response to hydrogen peroxide
GO:0009267	IEA:Ensembl	P	cellular response to starvation
GO:0019371	IEA:Ensembl	P	cyclooxygenase pathway
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0006954	IMP:MGI	P	inflammatory response
GO:0046834	ISA:GOC	P	lipid phosphorylation
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0045766	IEA:Ensembl	P	positive regulation of angiogenesis
GO:0030307	IEA:Ensembl	P	positive regulation of cell growth
GO:0030335	IEA:Ensembl	P	positive regulation of cell migration
GO:0008284	IGI:MGI	P	positive regulation of cell proliferation
GO:0048146	IEA:Ensembl	P	positive regulation of fibroblast proliferation
GO:0045931	IEA:Ensembl	P	positive regulation of mitotic cell cycle
GO:0010976	IEA:Ensembl	P	positive regulation of neuron projection development
GO:0001956	IEA:Ensembl	P	positive regulation of neurotransmitter secretion
GO:0042346	ISS:UniProtKB	P	positive regulation of NF-kappaB import into nucleus
GO:0051092	ISS:UniProtKB	P	positive regulation of NF-kappaB transcription factor activity
GO:0001934	IEA:Ensembl	P	positive regulation of protein phosphorylation
GO:0031398	ISS:UniProtKB	P	positive regulation of protein ubiquitination
GO:0045987	IEA:Ensembl	P	positive regulation of smooth muscle contraction
GO:0007205	IEA:InterPro	P	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0032651	IMP:MGI	P	regulation of interleukin-1 beta production
GO:0010803	ISS:UniProtKB	P	regulation of tumor necrosis factor-mediated signaling pathway
GO:0014075	IEA:Ensembl	P	response to amine
GO:0033198	IEA:Ensembl	P	response to ATP
GO:0070555	IEA:Ensembl	P	response to interleukin-1
GO:0032026	IEA:Ensembl	P	response to magnesium ion
GO:0032570	IEA:Ensembl	P	response to progesterone
GO:0006670	ISS:UniProtKB	P	sphingosine metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
mmu04020	Calcium signaling pathway
mmu04666	Fc gamma R-mediated phagocytosis
mmu05152	Tuberculosis
mmu04370	VEGF signaling pathway