LMPD Database

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LMP012510

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 7, subfamily a, polypeptide 1
Protein EntryCP7A1_RAT
UniProt IDP18125
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityCholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O. {ECO:0000269|PubMed:1694852, ECO:0000269|PubMed:2335522}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Enzyme RegulationInhibition of activity by bile acid feedback.
FunctionCatalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis
InductionUp-regulated by dietary cholesterol and cholestyramine. Down-regulated by dietary bile acids, such as chenodeoxycholic acid and cholic acid. {ECO:0000269|PubMed:11278771, ECO:0000269|PubMed:1694852, ECO:0000269|PubMed:2335522}.
PathwayLipid metabolism; bile acid biosynthesis.
SimilarityBelongs to the cytochrome P450 family
Subcellular LocationEndoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .
Tissue SpecificityDetected in liver (at protein level). Liver