Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

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Heatmap of ATP/KLA timecourse data for lipid category SP (Ratio to control values)

Gene Time course graph Description Treatment 15min 30min 1min 2min 4min 8min 20min Asah1 KLA  ATP  ATP+KLA N-acylsphingosine amidohydrolase 1 (Asah1), mRNA [NM_019734] KLA 0.80 0.84 0.83 0.69 0.72 0.78 1.09   ATP 1.04 1.25 0.99 1.15 0.81 0.53 0.72   ATP+KLA 0.86 0.89 0.62 0.81 0.51 0.47 0.48 Cerk KLA  ATP  ATP+KLA ceramide kinase (Cerk), mRNA [NM_145475] KLA 0.27 0.26 0.23 0.27 0.38 0.83 0.97   ATP 1.02 0.99 0.88 0.78 1.40 1.18 2.22   ATP+KLA 0.28 0.26 0.28 0.28 1.58 1.53 2.18 Degs1 KLA  ATP  ATP+KLA degenerative spermatocyte homolog 1 (Drosophila) (Degs1), mRNA [NM_007853] KLA 0.83 0.80 0.78 0.74 0.58 0.38 0.67   ATP 1.14 1.08 1.10 1.18 1.53 1.19 0.96   ATP+KLA 0.88 0.88 0.82 0.78 0.76 0.57 0.52 Degs2 KLA  ATP  ATP+KLA degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase (Degs2), mRNA [NM_027299] KLA 1.03 0.99 0.93 0.99 1.05 1.03 0.94   ATP 1.00 1.02 1.05 0.97 1.06 0.92 0.99   ATP+KLA 1.04 1.06 1.00 0.93 1.00 0.94 0.94 Kdsr KLA  ATP  ATP+KLA 3-ketodihydrosphingosine reductase (Kdsr), mRNA [NM_027534] KLA 0.54 0.46 0.41 0.39 0.38 0.40 0.46   ATP 0.97 0.97 1.23 1.13 1.00 0.68 0.52   ATP+KLA 0.47 0.48 0.59 0.69 0.92 0.55 0.30 Lass2 KLA  ATP  ATP+KLA LAG1 homolog, ceramide synthase 2 (Lass2), mRNA [NM_029789] KLA 0.79 0.81 0.81 0.68 0.72 0.72 1.08   ATP 1.02 1.11 0.95 1.07 0.94 0.70 1.25   ATP+KLA 0.86 0.86 0.62 0.78 0.64 0.63 0.97 Lass4 KLA  ATP  ATP+KLA 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630036I10 product:longevity assurance homolog 4 (S. cerevisiae), full insert sequence. [AK036108] KLA 0.86 0.82 0.81 0.76 0.78 0.71 0.76   ATP 1.05 0.97 0.93 0.71 0.86 0.79 0.75   ATP+KLA 0.90 0.81 0.80 0.72 0.80 0.74 0.72 Lass4 KLA  ATP  ATP+KLA LAG1 homolog, ceramide synthase 4 (Lass4), mRNA [NM_026058] KLA 0.64 0.61 0.59 0.67 0.59 0.56 0.55   ATP 0.91 0.92 1.09 0.90 0.62 0.55 0.61   ATP+KLA 0.62 0.65 0.73 0.66 0.59 0.55 0.55 Lass5 KLA  ATP  ATP+KLA LAG1 homolog, ceramide synthase 5 (Lass5), mRNA [NM_028015] KLA 0.62 0.60 0.53 0.42 0.37 0.34 0.66   ATP 1.05 1.15 1.02 1.21 0.85 0.53 0.90   ATP+KLA 0.68 0.64 0.53 0.54 0.39 0.37 0.42 Lass6 KLA  ATP  ATP+KLA LAG1 homolog, ceramide synthase 6 (Lass6), mRNA [NM_172856] KLA 8.82 11.21 11.49 12.30 10.83 7.97 7.15   ATP 1.11 1.13 1.22 1.58 2.13 4.41 4.45   ATP+KLA 10.82 12.09 9.72 11.37 7.17 5.10 9.51 Lass6 KLA  ATP  ATP+KLA adult male colon cDNA, RIKEN full-length enriched library, clone:9030601N10 product:unclassifiable, full insert sequence [AK136463] KLA 6.80 6.12 6.10 6.59 4.37 2.19 3.16   ATP 1.11 1.03 1.26 1.13 2.24 2.53 0.84   ATP+KLA 6.23 6.58 7.50 5.95 5.29 2.64 1.33 Ppap2a KLA  ATP  ATP+KLA phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 2.62 2.85 4.01 5.61 7.83 10.88 16.34   ATP 1.00 1.02 1.09 1.28 1.26 2.38 1.44   ATP+KLA 2.78 2.77 2.99 3.42 2.85 3.58 6.58 Ppap2b KLA  ATP  ATP+KLA phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 2.73 2.72 2.65 2.39 1.07 1.48 3.26   ATP 0.99 0.97 1.60 2.76 18.64 27.23 9.19   ATP+KLA 2.69 2.80 4.36 4.20 14.33 15.32 17.91 Ppap2c KLA  ATP  ATP+KLA phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA 0.94 0.88 0.91 0.79 0.65 0.46 0.51   ATP 1.01 1.03 1.00 1.12 1.24 0.90 0.83   ATP+KLA 0.95 0.93 0.87 0.95 0.79 0.63 0.43 Sgms1 KLA  ATP  ATP+KLA sphingomyelin synthase 1 (Sgms1), mRNA [NM_144792] KLA 0.84 0.83 0.58 0.94 1.49 0.66 0.71   ATP 0.97 0.97 1.57 1.85 1.31 1.59 0.57   ATP+KLA 0.82 0.72 0.90 0.96 0.67 0.81 0.55 Sgpl1 KLA  ATP  ATP+KLA sphingosine phosphate lyase 1 (Sgpl1), mRNA [NM_009163] KLA 0.89 0.84 0.89 0.90 0.83 0.85 1.09   ATP 1.17 1.14 0.74 0.82 1.35 1.56 1.75   ATP+KLA 1.01 0.97 0.64 0.81 1.07 1.45 1.97 Smpd1 KLA  ATP  ATP+KLA sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1), mRNA [NM_011421] KLA 0.68 0.66 0.67 0.87 0.91 1.01 1.11   ATP 1.04 1.02 1.06 1.03 1.02 1.30 1.73   ATP+KLA 0.69 0.68 0.86 0.71 0.78 0.99 1.64 Sphk1 KLA  ATP  ATP+KLA sphingosine kinase 1 (Sphk1), transcript variant 2, mRNA [NM_025367] KLA 2.61 2.50 2.04 1.71 1.19 0.91 0.73   ATP 0.94 0.99 2.06 8.09 16.52 12.59 3.53   ATP+KLA 2.64 2.81 3.50 8.12 23.70 16.46 2.22 Sphk2 KLA  ATP  ATP+KLA sphingosine kinase 2 (Sphk2), transcript variant 2, mRNA [NM_020011] KLA 0.64 0.74 1.05 1.47 2.15 1.84 1.67   ATP 1.10 1.02 0.57 0.54 0.49 1.29 2.15   ATP+KLA 0.78 0.64 0.43 0.56 0.86 1.90 3.74 Sptlc1 KLA  ATP  ATP+KLA serine palmitoyltransferase, long chain base subunit 1 (Sptlc1), mRNA [NM_009269] KLA 1.34 1.32 1.35 1.36 1.26 1.30 1.31   ATP 0.98 1.04 1.06 1.00 0.76 1.02 1.57   ATP+KLA 1.27 1.44 1.37 1.27 0.91 1.12 1.57 Sptlc2 KLA  ATP  ATP+KLA serine palmitoyltransferase, long chain base subunit 2 (Sptlc2), mRNA [NM_011479] KLA 2.03 2.10 2.53 2.42 2.17 1.88 1.45   ATP 1.08 1.10 1.17 1.27 2.52 4.23 1.87   ATP+KLA 2.17 2.37 2.54 2.82 3.28 4.03 2.41 Ugcg KLA  ATP  ATP+KLA UDP-glucose ceramide glucosyltransferase (Ugcg), mRNA [NM_011673] KLA 2.82 2.77 2.92 2.52 1.85 1.64 1.75   ATP 1.04 1.22 1.54 2.42 5.88 4.88 1.65   ATP+KLA 3.04 3.21 3.10 3.92 5.18 5.21 2.64 Ugcg KLA  ATP  ATP+KLA UDP-glucose ceramide glucosyltransferase, mRNA (cDNA clone MGC:59317 IMAGE:6512920), complete cds [BC050828] KLA 3.14 2.80 2.93 3.01 1.88 1.45 1.73   ATP 1.22 1.28 1.11 1.66 6.31 4.52 1.39   ATP+KLA 3.05 3.59 2.52 3.22 4.86 5.40 2.39 Ugt8a KLA  ATP  ATP+KLA UDP galactosyltransferase 8A (Ugt8a), mRNA [NM_011674] KLA 1.02 1.03 1.03 0.99 0.97 1.08 0.99   ATP 0.98 1.01 1.01 1.02 1.00 1.06 1.07   ATP+KLA 0.98 1.05 1.03 0.94 1.01 0.98 1.03