Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Pentose phosphate pathway (mmu00030)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK077927
KLA  ATP  ATP+KLA
 AK077927 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030447B09 product:unclassifiable, full insert sequence. [AK077927] KLA 3.15 2.64 2.14 1.56 1.86 1.87 1.23
ATP .91 .63 .45 .45 1.18 1.41 .90
KLA/ATP 2.53 2.04 1.88 .94 1.59 1.96 1.21
AU021838
KLA  ATP  ATP+KLA
 AK032842 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720461H18 product:unclassifiable, full insert sequence [AK032842] KLA .87 .74 .81 .58 .51 .52 .55
ATP 1.00 1.03 1.09 .76 .43 .45 .42
KLA/ATP .81 .82 .68 .56 .38 .37 .31
Aldoa
KLA  ATP  ATP+KLA
 NM_007438 aldolase 1, A isoform (Aldoa), mRNA [NM_007438] KLA .81 .83 .75 .81 .83 .80 1.22
ATP .97 .93 .78 .78 1.01 1.14 1.35
KLA/ATP .80 .86 .84 .70 .80 .81 1.12
Aldoart1
KLA  ATP  ATP+KLA
 AK016845 adult male testis cDNA, RIKEN full-length enriched library, clone:4933417I20 product:ALDOLASE 1, A ISOFORM homolog [Mus musculus], full insert sequence [AK016845] KLA 1.01 1.01 1.03 .98 .95 .96 1.03
ATP 1.00 1.01 .98 .90 .99 1.03 .91
KLA/ATP .97 1.01 1.04 .99 1.07 1.00 .98
Aldob
KLA  ATP  ATP+KLA
 NM_144903 aldolase 2, B isoform (Aldob), mRNA [NM_144903] KLA .99 1.01 1.02 1.02 1.02 1.03 1.04
ATP 1.02 1.02 1.00 1.05 1.02 1.02 1.01
KLA/ATP 1.01 1.04 1.00 1.03 1.03 1.02 .97
Aldoc
KLA  ATP  ATP+KLA
 AK039267 adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330009L16 product:aldolase 3, C isoform, full insert sequence [AK039267] KLA .84 .77 .75 .78 .51 .34 .14
ATP .86 .84 1.15 1.01 .85 .60 .33
KLA/ATP .71 .78 .94 .76 .60 .34 .14
Aldoc
KLA  ATP  ATP+KLA
 NM_009657 aldolase 3, C isoform (Aldoc), mRNA [NM_009657] KLA .88 .94 .93 .76 .72 .46 .16
ATP 1.02 1.17 1.00 1.29 1.00 .62 .76
KLA/ATP .99 1.00 .82 1.04 .71 .46 .18
Dera
KLA  ATP  ATP+KLA
 NM_172733 2-deoxyribose-5-phosphate aldolase homolog (C. elegans) (Dera), mRNA [NM_172733] KLA 1.01 1.05 1.06 1.14 1.28 1.72 2.05
ATP 1.11 1.08 1.14 1.40 1.21 .86 1.85
KLA/ATP 1.15 1.21 1.04 1.18 1.01 .94 1.80
Fbp1
KLA  ATP  ATP+KLA
 NM_019395 fructose bisphosphatase 1 (Fbp1), mRNA [NM_019395] KLA .91 .95 1.03 1.01 1.00 1.02 .80
ATP .96 .96 .99 .95 .86 .84 .64
KLA/ATP .88 .96 .87 .92 .92 .84 .70
Fbp2
KLA  ATP  ATP+KLA
 NM_007994 fructose bisphosphatase 2 (Fbp2), mRNA [NM_007994] KLA 1.03 1.03 .95 1.02 1.02 1.03 1.06
ATP 1.03 1.03 1.05 1.01 .97 1.01 1.17
KLA/ATP .96 .92 1.06 .85 1.07 .97 1.12
G6pd2
KLA  ATP  ATP+KLA
 NM_019468 glucose-6-phosphate dehydrogenase 2 (G6pd2), mRNA [NM_019468] KLA 1.07 1.13 1.31 .96 1.22 1.19 1.70
ATP 1.23 1.51 .85 1.48 .93 .89 1.34
KLA/ATP 1.56 1.52 .71 1.40 .72 1.04 2.61
G6pdx
KLA  ATP  ATP+KLA
 NM_008062 glucose-6-phosphate dehydrogenase X-linked (G6pdx), mRNA [NM_008062] KLA .77 .81 .85 .74 .84 .90 1.44
ATP 1.11 1.12 .85 .85 .76 .86 1.07
KLA/ATP .96 .88 .63 .72 .58 .77 1.91
Gpi1
KLA  ATP  ATP+KLA
 L09104 glucose phosphate isomerase mRNA, 3 end. [L09104] KLA .92 1.02 .99 1.01 .92 1.04 1.07
ATP 1.05 1.06 1.11 1.14 1.01 1.00 1.04
KLA/ATP 1.06 1.09 1.01 .96 .93 .93 1.04
Gpi1
KLA  ATP  ATP+KLA
 NM_008155 glucose phosphate isomerase 1 (Gpi1), mRNA [NM_008155] KLA .77 .76 .69 .66 .61 .59 .85
ATP .96 .97 .97 .93 .90 .73 .77
KLA/ATP .75 .76 .73 .69 .66 .54 .59
H6pd
KLA  ATP  ATP+KLA
 NM_173371 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (H6pd), mRNA [NM_173371] KLA .89 .91 .89 .78 .64 .85 1.14
ATP .98 1.06 .86 .67 .38 .49 1.45
KLA/ATP .96 .96 .81 .70 .44 .43 1.19
Mm.17905
KLA  ATP  ATP+KLA
 94536843 Unknown KLA 1.05 1.02 1.06 1.01 .76 .88 .91
ATP .91 .83 1.42 .91 .93 1.14 1.10
KLA/ATP 1.01 1.05 1.76 1.10 1.06 .89 .88
Mm.45856
3
KLA  ATP  ATP+KLA
 142351405 Unknown KLA .93 .96 .85 .74 .64 .68 .87
ATP 1.03 1.07 1.02 1.04 .94 1.01 1.14
KLA/ATP .98 .98 .75 .87 .68 1.02 1.15
Mm.79179
KLA  ATP  ATP+KLA
 141803280 Unknown KLA .95 1.09 1.04 1.13 1.00 1.10 .98
ATP 1.02 1.17 1.04 1.18 1.06 1.02 1.01
KLA/ATP .98 1.00 1.02 1.01 .98 .93 .99
Pfkl
KLA  ATP  ATP+KLA
 NM_008826 phosphofructokinase, liver, B-type (Pfkl), mRNA [NM_008826] KLA 1.19 1.33 1.34 1.23 1.57 1.49 2.02
ATP 1.17 1.34 1.04 1.45 .92 1.53 .97
KLA/ATP 1.54 1.64 1.36 1.91 1.17 .89 1.61
Pfkm
KLA  ATP  ATP+KLA
 NM_021514 phosphofructokinase, muscle (Pfkm), mRNA [NM_021514] KLA .73 .74 .70 .88 .80 .61 .55
ATP 1.09 1.05 1.01 1.06 .80 .50 .52
KLA/ATP .76 .83 .86 .75 .57 .57 .46
Pfkp
KLA  ATP  ATP+KLA
 BC050264 gb|Mus musculus, clone IMAGE:4503748, mRNA [BC050264] KLA 4.07 3.58 3.25 2.41 1.31 .76 .81
ATP 1.26 1.26 2.77 2.20 4.63 2.57 4.92
KLA/ATP 4.81 4.66 8.95 3.50 3.96 1.60 .91
Pfkp
KLA  ATP  ATP+KLA
 NM_019703 phosphofructokinase, platelet (Pfkp), mRNA [NM_019703] KLA 1.94 1.99 2.15 2.05 1.90 1.20 .85
ATP 1.08 1.05 1.18 1.20 1.40 1.38 .93
KLA/ATP 1.94 2.12 2.35 2.26 1.91 1.36 .88
Pgd
KLA  ATP  ATP+KLA
 NM_001081274 phosphogluconate dehydrogenase (Pgd), mRNA [NM_001081274] KLA .91 .94 .94 .76 .80 .67 .93
ATP 1.11 1.22 .84 .96 1.20 1.82 1.59
KLA/ATP 1.01 1.10 .79 .90 .83 1.30 1.75
Pgls
KLA  ATP  ATP+KLA
 NM_025396 6-phosphogluconolactonase (Pgls), mRNA [NM_025396] KLA .82 .84 .72 .74 .68 .58 .74
ATP 1.08 1.13 .94 1.33 1.06 .66 .59
KLA/ATP .94 .94 .81 .97 .72 .54 .46
Pgm1
KLA  ATP  ATP+KLA
 NM_025700 phosphoglucomutase 1 (Pgm1), mRNA [NM_025700] KLA 1.08 1.03 .95 .75 .59 .55 .73
ATP 1.02 1.23 1.22 1.42 1.07 .75 1.01
KLA/ATP 1.01 1.10 .84 1.12 .69 .61 .51
Pgm2
KLA  ATP  ATP+KLA
 NM_028132 phosphoglucomutase 2 (Pgm2), mRNA [NM_028132] KLA 1.13 1.21 1.26 1.48 1.52 1.81 1.81
ATP .90 .92 1.07 .99 .80 1.60 1.17
KLA/ATP 1.01 1.16 1.40 1.25 1.48 1.99 1.94
Prps1
KLA  ATP  ATP+KLA
 NM_021463 phosphoribosyl pyrophosphate synthetase 1 (Prps1), mRNA [NM_021463] KLA .82 .83 .85 .70 .56 .42 .52
ATP 1.00 1.03 1.20 1.21 1.08 .67 .54
KLA/ATP .85 .86 .90 .86 .68 .52 .42
Prps1l1
KLA  ATP  ATP+KLA
 NM_029294 phosphoribosyl pyrophosphate synthetase 1-like 1 (Prps1l1), mRNA [NM_029294] KLA 1.05 .97 .99 1.03 1.04 1.00 1.04
ATP .99 .96 1.04 1.05 1.05 .99 1.07
KLA/ATP .99 1.03 1.07 1.00 1.01 1.01 1.09
Prps2
KLA  ATP  ATP+KLA
 NM_026662 phosphoribosyl pyrophosphate synthetase 2 (Prps2), mRNA [NM_026662] KLA .85 .85 .88 .76 .60 .45 .43
ATP 1.00 1.13 1.18 1.19 .79 .35 .37
KLA/ATP .85 .93 .88 .83 .62 .38 .24
Rbks
KLA  ATP  ATP+KLA
 NM_153196 ribokinase (Rbks), mRNA [NM_153196] KLA 1.11 1.05 1.04 1.12 1.01 1.21 1.36
ATP .98 1.00 1.34 1.63 1.26 .83 1.28
KLA/ATP 1.02 1.12 1.37 1.65 1.44 1.20 2.01
Rgn
KLA  ATP  ATP+KLA
 NM_009060 regucalcin (Rgn), mRNA [NM_009060] KLA .99 .94 .99 .93 .97 1.00 1.04
ATP .98 1.03 .95 .98 .95 .96 .91
KLA/ATP .93 1.03 1.01 .98 .94 .93 .94
Rpe
KLA  ATP  ATP+KLA
 NM_025683 ribulose-5-phosphate-3-epimerase (Rpe), mRNA [NM_025683] KLA 2.06 2.10 2.39 2.33 2.29 2.01 1.45
ATP 1.01 1.14 1.25 1.29 .90 .80 .89
KLA/ATP 1.87 2.38 2.22 2.33 1.57 1.08 1.10
Taldo1
KLA  ATP  ATP+KLA
 NM_011528 transaldolase 1 (Taldo1), mRNA [NM_011528] KLA .82 .79 .79 .76 .63 .56 .56
ATP .93 .96 1.02 .91 1.13 1.91 2.17
KLA/ATP .77 .80 .86 .75 .94 1.33 1.43
Tkt
KLA  ATP  ATP+KLA
 NM_009388 transketolase (Tkt), mRNA [NM_009388] KLA .97 1.00 .97 1.00 .90 .86 .90
ATP .99 1.00 1.03 .97 .89 .83 .58
KLA/ATP 1.01 1.00 .97 .91 .80 .76 .51
Tktl1
KLA  ATP  ATP+KLA
 NM_031379 transketolase-like 1 (Tktl1), mRNA [NM_031379] KLA 1.07 1.01 .98 1.03 .97 .99 .93
ATP 1.02 1.02 .98 .91 .99 1.06 .95
KLA/ATP .96 .98 .96 .99 1.05 .99 1.00
Tktl2
KLA  ATP  ATP+KLA
 AK029871 adult male testis cDNA, RIKEN full-length enriched library, clone:4931419A11 product:TRANSKETOLASE (FRAGMENT) homolog [Mus musculus], full insert sequence [AK029871] KLA 1.09 1.03 1.10 .98 1.03 .96 .94
ATP .96 1.05 .99 1.00 .94 1.02 1.02
KLA/ATP .95 .92 1.15 1.06 .99 .93 .98
Tktl2
KLA  ATP  ATP+KLA
 NM_028927 transketolase-like 2 (Tktl2), mRNA [NM_028927] KLA 1.02 .98 .98 .98 1.01 .97 .98
ATP 1.06 1.01 1.01 .99 .93 1.01 1.06
KLA/ATP 1.02 1.03 .98 .99 .96 1.00 .99