Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Steroid biosynthesis (mmu00100)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Cel
KLA  ATP  ATP+KLA
 NM_009885 carboxyl ester lipase (Cel), mRNA [NM_009885] KLA 1.06 1.02 1.06 1.07 1.07 1.08 1.11
ATP 1.01 1.04 1.18 1.09 1.09 1.21 1.09
KLA/ATP 1.06 .97 1.24 1.16 1.19 1.21 1.10
Cyp24a1
KLA  ATP  ATP+KLA
 NM_009996 cytochrome P450, family 24, subfamily a, polypeptide 1 (Cyp24a1), nuclear gene encoding mitochondrial protein, mRNA [NM_009996] KLA .98 .91 1.01 1.00 1.01 1.01 1.02
ATP .97 .93 1.01 1.01 1.01 .97 1.05
KLA/ATP 1.00 1.04 .98 .95 .97 1.03 .85
Cyp27b1
KLA  ATP  ATP+KLA
 AB006034 mRNA for 25-hydroxyvitamin D3 1alpha-hydroxylase, partial cds. [AB006034] KLA 1.04 .99 .98 .99 .97 .97 1.00
ATP 1.00 .99 .94 .99 1.05 .95 1.00
KLA/ATP 1.02 .97 .99 .99 .97 .92 1.00
Cyp27b1
KLA  ATP  ATP+KLA
 NM_010009 cytochrome P450, family 27, subfamily b, polypeptide 1 (Cyp27b1), nuclear gene encoding mitochondrial protein, mRNA [NM_010009] KLA 1.18 1.18 1.27 1.18 1.24 1.23 1.12
ATP 1.07 .95 1.21 1.13 1.17 1.17 1.03
KLA/ATP 1.13 1.10 1.36 1.27 1.34 1.13 1.06
Cyp2r1
KLA  ATP  ATP+KLA
 NM_177382 cytochrome P450, family 2, subfamily r, polypeptide 1 (Cyp2r1), mRNA [NM_177382] KLA .98 1.09 1.11 1.07 1.12 1.16 1.47
ATP 1.05 1.11 1.12 1.00 .84 .69 1.11
KLA/ATP 1.05 1.01 1.17 .99 .85 .76 .79
Cyp51
KLA  ATP  ATP+KLA
 NM_020010 cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA 1.05 1.08 1.11 .93 .82 .50 .52
ATP 1.01 1.07 1.27 1.22 .98 .75 1.09
KLA/ATP 1.06 1.10 1.09 1.03 .72 .44 .39
Dhcr24
KLA  ATP  ATP+KLA
 NM_053272 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA .50 .50 .44 .42 .35 .28 .36
ATP 1.09 1.12 1.01 1.09 .72 .43 1.05
KLA/ATP .51 .54 .46 .54 .33 .22 .18
Dhcr7
KLA  ATP  ATP+KLA
 NM_007856 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA .58 .54 .52 .49 .39 .47 .71
ATP 1.01 1.09 1.17 1.19 .71 .39 .74
KLA/ATP .58 .56 .58 .64 .47 .45 .32
Ebp
KLA  ATP  ATP+KLA
 NM_007898 phenylalkylamine Ca2+ antagonist (emopamil) binding protein (Ebp), mRNA [NM_007898] KLA .77 .75 .66 .77 .61 .71 .67
ATP .83 .83 1.15 .99 .88 .83 .95
KLA/ATP .67 .72 .95 .79 .86 .75 .74
Hsd17b7
KLA  ATP  ATP+KLA
 NM_010476 hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), mRNA [NM_010476] KLA .87 .86 .78 .85 .86 .76 .77
ATP 1.05 .94 1.22 .87 .69 .67 1.48
KLA/ATP .88 .76 .91 .70 .53 .34 .36
Lipa
KLA  ATP  ATP+KLA
 AK083099 adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630012O05 product:unclassifiable, full insert sequence. [AK083099] KLA .46 .38 .29 .31 .42 .55 .68
ATP .69 .39 .26 .79 1.80 1.07 .96
KLA/ATP .39 .32 .40 .86 1.05 .85 .85
Lipa
KLA  ATP  ATP+KLA
 NM_021460 lysosomal acid lipase A (Lipa), transcript variant 1, mRNA [NM_021460] KLA .51 .50 .54 .36 .29 .32 .46
ATP .89 1.09 .86 .80 .83 1.00 .88
KLA/ATP .48 .57 .44 .49 .44 .67 .63
Lss
KLA  ATP  ATP+KLA
 AK147680 adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] KLA .52 .46 .46 .47 .49 .43 .44
ATP .93 .92 1.44 .97 .55 .39 .46
KLA/ATP .46 .45 .56 .47 .44 .32 .15
Lss
KLA  ATP  ATP+KLA
 NM_146006 lanosterol synthase (Lss), mRNA [NM_146006] KLA .77 .80 .87 .80 .90 .70 .80
ATP 1.04 1.09 1.03 1.18 .73 .67 1.63
KLA/ATP .79 .89 .87 .88 .57 .46 .43
Nsdhl
KLA  ATP  ATP+KLA
 AK156993 activated spleen cDNA, RIKEN full-length enriched library, clone:F830111P16 product:unclassifiable, full insert sequence [AK156993] KLA 1.06 .94 .95 .88 1.09 .86 .76
ATP 1.14 1.03 1.03 .75 .75 .92 1.02
KLA/ATP 1.05 .98 .92 .70 .84 .71 .76
Nsdhl
KLA  ATP  ATP+KLA
 NM_010941 NAD(P) dependent steroid dehydrogenase-like (Nsdhl), mRNA [NM_010941] KLA .98 1.05 1.03 .95 .97 .87 .89
ATP 1.02 1.16 1.11 1.33 .91 .57 1.05
KLA/ATP 1.08 1.02 .86 1.20 .77 .58 .47
Sc4mol
KLA  ATP  ATP+KLA
 NM_025436 sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] KLA .43 .37 .41 .44 .44 .41 .54
ATP .95 .92 1.30 .92 .70 .47 1.36
KLA/ATP .41 .37 .45 .38 .35 .23 .37
Sc5d
KLA  ATP  ATP+KLA
 AK080673 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830073K23 product:unclassifiable, full insert sequence [AK080673] KLA .62 .56 .53 .46 .38 .29 .35
ATP .87 .91 1.37 .86 .56 .43 .33
KLA/ATP .54 .49 .72 .72 .72 .39 .20
Sc5d
KLA  ATP  ATP+KLA
 NM_172769 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d), mRNA [NM_172769] KLA 1.18 1.19 1.17 1.09 .95 .63 .70
ATP .99 1.00 1.31 1.09 .84 1.04 1.51
KLA/ATP 1.09 1.08 1.30 1.20 1.05 .88 .76
Soat1
KLA  ATP  ATP+KLA
 NM_009230 sterol O-acyltransferase 1 (Soat1), mRNA [NM_009230] KLA .68 .68 .62 .63 .59 .84 1.33
ATP 1.06 1.16 1.02 1.10 .92 .79 1.51
KLA/ATP .72 .71 .57 .72 .64 .66 1.29
Soat2
KLA  ATP  ATP+KLA
 NM_146064 sterol O-acyltransferase 2 (Soat2), mRNA [NM_146064] KLA 1.03 .91 1.03 1.07 1.52 1.83 2.92
ATP .97 .99 1.06 .84 .81 .93 2.17
KLA/ATP .99 .93 1.01 .94 .94 1.07 2.74
Tm7sf2
KLA  ATP  ATP+KLA
 NM_028454 transmembrane 7 superfamily member 2 (Tm7sf2), mRNA [NM_028454] KLA .93 .90 .79 .88 .63 .52 .33
ATP .84 .94 .97 1.03 .76 .60 .51
KLA/ATP .82 .94 .90 .95 .67 .47 .27