Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Tyrosine metabolism (mmu00350)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
1700055N
04Rik
KLA  ATP  ATP+KLA
 AK081788 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130077J09 product:weakly similar to ALDEHYDE DEHYDROGENASE 7 (EC 1.2.1.5) [Homo sapiens], full insert sequence [AK081788] KLA .96 .98 .95 .97 .97 .96 1.06
ATP 1.01 1.00 .97 1.10 .95 .99 1.02
KLA/ATP .99 1.00 .97 1.00 1.00 .96 .97
4930438A
08Rik
KLA  ATP  ATP+KLA
 XM_001477470 gb|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470] KLA 1.78 1.45 1.69 1.62 1.69 1.48 1.31
ATP 1.07 1.04 1.24 1.13 1.13 1.61 1.67
KLA/ATP 1.83 1.46 1.58 1.30 1.43 1.36 1.95
Adh1
KLA  ATP  ATP+KLA
 AK082149 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230014D21 product:unclassifiable, full insert sequence [AK082149] KLA .94 .96 .97 .95 1.01 .95 .96
ATP .99 1.05 .93 .91 1.02 1.04 1.00
KLA/ATP .87 .88 .94 .92 .86 1.04 .93
Adh1
KLA  ATP  ATP+KLA
 NM_007409 alcohol dehydrogenase 1 (class I) (Adh1), mRNA [NM_007409] KLA 1.02 .98 .96 1.04 1.01 1.04 1.08
ATP .96 1.03 1.00 1.03 1.05 1.01 1.04
KLA/ATP 1.02 1.03 1.04 1.01 1.04 1.09 1.04
Adh4
KLA  ATP  ATP+KLA
 NM_011996 alcohol dehydrogenase 4 (class II), pi polypeptide (Adh4), mRNA [NM_011996] KLA .95 .94 .93 1.07 1.04 .96 .99
ATP .95 .95 .95 .99 1.02 .93 .97
KLA/ATP 1.03 1.02 .92 .97 1.02 1.01 .99
Adh5
KLA  ATP  ATP+KLA
 NM_007410 alcohol dehydrogenase 5 (class III), chi polypeptide (Adh5), mRNA [NM_007410] KLA .93 .76 .71 .83 .61 .63 .76
ATP 1.02 .98 1.19 1.06 1.08 .85 .86
KLA/ATP .77 .76 1.06 .86 .87 .84 .62
Adh7
KLA  ATP  ATP+KLA
 NM_009626 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (Adh7), mRNA [NM_009626] KLA 1.07 1.01 1.02 .98 1.03 .99 1.01
ATP 1.03 1.09 1.02 1.08 1.03 1.09 1.01
KLA/ATP 1.10 1.03 1.06 1.02 1.05 1.06 1.13
Aldh1a3
KLA  ATP  ATP+KLA
 AK086764 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930050B08 product:aldehyde dehydrogenase family 1, subfamily A3, full insert sequence. [AK086764] KLA .97 1.05 1.05 1.01 1.00 .98 .97
ATP 1.00 1.03 .99 .92 1.01 1.09 1.02
KLA/ATP 1.01 .99 1.06 1.00 .97 .98 1.00
Aldh1a3
KLA  ATP  ATP+KLA
 NM_053080 aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), mRNA [NM_053080] KLA 1.03 .96 1.03 1.03 .96 .98 1.01
ATP .98 1.04 1.01 1.06 .98 1.01 1.08
KLA/ATP 1.02 1.00 1.02 .94 1.03 .99 .99
Aldh3a1
KLA  ATP  ATP+KLA
 NM_007436 aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1), transcript variant 1, mRNA [NM_007436] KLA .98 .98 1.03 1.01 1.03 1.04 .97
ATP .98 1.01 1.06 .95 1.00 .96 1.02
KLA/ATP 1.07 1.08 .99 .98 1.03 .93 .98
Aldh3b1
KLA  ATP  ATP+KLA
 NM_026316 aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), mRNA [NM_026316] KLA .82 .77 .69 .77 .72 .97 1.31
ATP .88 .85 1.13 .89 .71 .56 1.25
KLA/ATP .66 .72 .84 .66 .66 .52 1.17
Aldh3b2
KLA  ATP  ATP+KLA
 XM_129134 gb|PREDICTED: Mus musculus aldehyde dehydrogenase 3 family, member B2 (Aldh3b2), mRNA [XM_129134] KLA .91 .93 .85 .88 1.01 .99 1.37
ATP 1.12 1.11 .99 1.19 .87 .61 1.31
KLA/ATP .86 1.02 .90 1.01 .72 .54 1.21
Aoc2
KLA  ATP  ATP+KLA
 NM_178932 amine oxidase, copper containing 2 (retina-specific) (Aoc2), mRNA [NM_178932] KLA 1.21 1.19 1.15 1.00 1.15 1.21 1.18
ATP 1.13 1.13 1.14 1.36 1.85 1.32 .76
KLA/ATP 1.27 1.34 1.12 1.32 1.67 1.37 1.05
Aoc3
KLA  ATP  ATP+KLA
 NM_009675 amine oxidase, copper containing 3 (Aoc3), mRNA [NM_009675] KLA .95 1.06 1.00 1.05 1.00 1.02 1.01
ATP 1.01 .90 1.04 1.07 1.06 1.06 .97
KLA/ATP 1.06 .98 .92 1.10 1.11 1.09 1.01
Aox1
KLA  ATP  ATP+KLA
 NM_009676 aldehyde oxidase 1 (Aox1), mRNA [NM_009676] KLA .87 .83 .82 .82 .71 .98 1.65
ATP 1.01 1.02 1.05 .84 .72 .86 .80
KLA/ATP .82 .84 .90 .73 .72 .82 1.06
Aox3
KLA  ATP  ATP+KLA
 NM_023617 aldehyde oxidase 3 (Aox3), mRNA [NM_023617] KLA .95 1.02 1.01 1.00 .99 1.01 1.04
ATP 1.04 1.03 1.01 .94 1.03 .92 .96
KLA/ATP 1.09 1.11 1.00 .97 .95 1.01 .94
Aox4
KLA  ATP  ATP+KLA
 NM_023631 aldehyde oxidase 4 (Aox4), mRNA [NM_023631] KLA .95 .97 .98 1.00 .98 .91 1.06
ATP .93 .99 .95 .99 .94 .95 1.00
KLA/ATP 1.05 1.00 .94 .98 .89 1.00 .93
Comt
KLA  ATP  ATP+KLA
 NM_007744 catechol-O-methyltransferase (Comt), transcript variant 2, mRNA [NM_007744] KLA .46 .45 .42 .38 .37 .38 .50
ATP .91 .90 .89 .84 .73 .38 .72
KLA/ATP .44 .44 .43 .37 .39 .31 .32
Dbh
KLA  ATP  ATP+KLA
 NM_138942 dopamine beta hydroxylase (Dbh), mRNA [NM_138942] KLA 1.01 1.08 1.18 1.11 1.17 1.25 1.19
ATP .95 1.03 1.04 1.10 1.11 1.06 1.06
KLA/ATP 1.12 1.04 1.05 1.17 1.16 1.11 1.11
Dct
KLA  ATP  ATP+KLA
 NM_010024 dopachrome tautomerase (Dct), mRNA [NM_010024] KLA 1.01 .97 .97 1.01 1.00 .99 1.02
ATP .97 1.00 1.00 1.00 .98 .98 1.01
KLA/ATP .97 1.01 1.07 1.02 .97 .95 1.04
Ddc
KLA  ATP  ATP+KLA
 NM_016672 dopa decarboxylase (Ddc), mRNA [NM_016672] KLA 1.27 1.28 1.34 1.33 1.34 1.21 1.05
ATP 1.02 .99 1.05 .98 1.02 1.02 1.14
KLA/ATP 1.24 1.22 1.28 1.25 1.12 1.20 1.35
Fah
KLA  ATP  ATP+KLA
 NM_010176 fumarylacetoacetate hydrolase (Fah), mRNA [NM_010176] KLA 1.01 1.09 1.04 1.13 1.02 .76 .69
ATP 1.09 1.09 1.02 1.22 1.08 .90 .58
KLA/ATP 1.14 1.09 1.13 1.19 .97 .91 .65
Fahd1
KLA  ATP  ATP+KLA
 NM_023480 fumarylacetoacetate hydrolase domain containing 1 (Fahd1), nuclear gene encoding mitochondrial protein, mRNA [NM_023480] KLA .36 .34 .34 .40 .42 .55 .63
ATP .88 .86 .83 .71 .35 .42 .73
KLA/ATP .34 .32 .39 .36 .37 .41 .52
Got1
KLA  ATP  ATP+KLA
 NM_010324 glutamate oxaloacetate transaminase 1, soluble (Got1), mRNA [NM_010324] KLA .68 .70 .66 .56 .50 .57 .99
ATP 1.01 1.24 1.55 1.59 1.47 1.03 1.68
KLA/ATP .68 .71 .66 .77 1.13 2.33 1.89
Got2
KLA  ATP  ATP+KLA
 NM_010325 glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325] KLA .84 .86 .88 .75 .75 .63 .61
ATP 1.02 1.12 .98 1.15 .98 .67 .86
KLA/ATP .92 .89 .75 .89 .68 .70 .77
Gstz1
KLA  ATP  ATP+KLA
 NM_010363 glutathione transferase zeta 1 (maleylacetoacetate isomerase) (Gstz1), mRNA [NM_010363] KLA .94 .85 .93 .85 .83 .71 .87
ATP 1.12 1.08 1.17 1.16 .78 .44 .71
KLA/ATP .96 .98 .97 1.03 .74 .47 .56
Hemk1
KLA  ATP  ATP+KLA
 NM_133984 HemK methyltransferase family member 1 (Hemk1), mRNA [NM_133984] KLA 1.05 1.10 1.13 1.07 1.10 1.12 1.20
ATP 1.01 1.00 .82 .81 .67 .82 1.26
KLA/ATP 1.11 1.15 1.03 .79 .76 .90 1.47
Hgd
KLA  ATP  ATP+KLA
 NM_013547 homogentisate 1, 2-dioxygenase (Hgd), mRNA [NM_013547] KLA .97 1.03 .95 1.05 1.02 1.00 .99
ATP 1.02 1.00 .99 .99 .97 .96 1.06
KLA/ATP 1.00 .96 1.00 .97 1.08 1.12 1.08
Hpd
KLA  ATP  ATP+KLA
 NM_008277 4-hydroxyphenylpyruvic acid dioxygenase (Hpd), mRNA [NM_008277] KLA .94 1.10 1.04 1.02 .97 .97 1.06
ATP 1.05 1.07 .96 1.01 1.09 .97 1.01
KLA/ATP 1.02 1.03 1.12 1.00 .98 1.06 1.02
Il4i1
KLA  ATP  ATP+KLA
 NM_010215 interleukin 4 induced 1 (Il4i1), mRNA [NM_010215] KLA 13.98 13.74 14.90 14.92 13.89 12.12 3.25
ATP 1.02 .98 1.14 1.59 4.45 6.63 2.41
KLA/ATP 16.09 15.56 19.65 19.66 18.47 14.84 12.99
Lao1
KLA  ATP  ATP+KLA
 NM_133892 L-amino acid oxidase 1 (Lao1), mRNA [NM_133892] KLA 1.03 1.03 1.04 1.00 .98 1.01 .98
ATP 1.01 1.03 1.02 .92 1.05 .98 .99
KLA/ATP 1.02 .96 1.04 .94 .96 .97 .97
Maoa
KLA  ATP  ATP+KLA
 NM_173740 monoamine oxidase A (Maoa), nuclear gene encoding mitochondrial protein, mRNA [NM_173740] KLA 1.14 1.11 1.06 1.07 .84 .55 .53
ATP 1.10 1.07 1.33 1.20 1.44 2.37 1.38
KLA/ATP .97 1.11 1.75 1.33 1.27 1.21 1.09
Maob
KLA  ATP  ATP+KLA
 NM_172778 monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA [NM_172778] KLA 1.01 .97 1.01 1.05 1.01 .95 1.01
ATP 1.09 .98 .99 .97 1.03 1.03 .94
KLA/ATP 1.02 1.05 .99 1.02 1.00 .98 .98
Mettl2
KLA  ATP  ATP+KLA
 NM_172567 methyltransferase like 2 (Mettl2), mRNA [NM_172567] KLA 1.19 1.15 1.16 .93 .84 .77 1.13
ATP .91 .87 .72 .71 .65 .82 .87
KLA/ATP 1.17 1.15 .94 .93 .59 .58 .53
Mettl6
KLA  ATP  ATP+KLA
 NM_025907 methyltransferase like 6 (Mettl6), mRNA [NM_025907] KLA 1.52 1.55 1.68 1.94 2.26 1.84 1.56
ATP 1.05 .96 .83 1.01 3.44 3.01 1.33
KLA/ATP 1.49 1.59 1.71 1.69 4.57 3.72 2.58
Mif
KLA  ATP  ATP+KLA
 NM_010798 macrophage migration inhibitory factor (Mif), mRNA [NM_010798] KLA .91 1.04 1.03 .89 1.01 .87 1.06
ATP 1.10 1.26 .98 1.34 1.22 1.11 .92
KLA/ATP 1.06 1.15 .85 1.30 1.09 1.17 1.08
Mm.15744
2
KLA  ATP  ATP+KLA
 41152515 Unknown KLA 1.09 1.07 .96 1.02 1.04 1.00 1.07
ATP 1.04 .96 .98 1.04 1.04 1.13 1.11
KLA/ATP 1.02 .97 1.03 1.04 1.15 1.23 1.25
Mm.23812
7
KLA  ATP  ATP+KLA
 168823498 Unknown KLA 1.07 .97 1.04 1.05 1.02 .98 1.02
ATP .95 1.00 .98 1.01 .95 .93 .92
KLA/ATP .93 .98 .98 1.04 1.01 1.02 .98
Mm.26684
3
KLA  ATP  ATP+KLA
 94405693 Unknown KLA 1.12 .99 .99 1.00 .97 .98 .96
ATP 1.02 1.08 1.01 .90 1.02 .97 .91
KLA/ATP 1.03 .96 .98 .91 1.05 .90 .97
Mm.34137
KLA  ATP  ATP+KLA
 94405716 Unknown KLA 1.11 1.12 1.10 1.07 1.08 1.13 1.36
ATP 1.09 1.14 1.01 1.25 .95 .79 1.23
KLA/ATP 1.01 1.24 .95 1.14 .83 .78 1.30
Mm.39052
9
KLA  ATP  ATP+KLA
 133892597 Unknown KLA .97 1.02 .97 .88 .79 .79 .92
ATP .93 1.10 1.07 1.22 .76 .47 .72
KLA/ATP .95 .99 .86 1.08 .67 .55 .67
Pnmt
KLA  ATP  ATP+KLA
 NM_008890 phenylethanolamine-N-methyltransferase (Pnmt), mRNA [NM_008890] KLA .97 .99 .99 .91 1.02 .97 1.02
ATP 1.02 1.03 .92 1.09 1.05 1.09 .96
KLA/ATP 1.00 1.02 1.02 .96 .96 .93 .95
Tat
KLA  ATP  ATP+KLA
 NM_146214 tyrosine aminotransferase (Tat), nuclear gene encoding mitochondrial protein, mRNA [NM_146214] KLA 1.13 1.09 1.19 1.17 1.14 1.19 1.10
ATP .97 1.08 1.12 1.25 1.02 1.16 1.18
KLA/ATP 1.16 1.21 1.27 1.23 1.22 1.11 1.08
Th
KLA  ATP  ATP+KLA
 NM_009377 tyrosine hydroxylase (Th), mRNA [NM_009377] KLA 1.00 1.01 1.00 1.00 1.00 1.00 1.00
ATP .98 1.01 1.00 1.00 1.00 .99 1.01
KLA/ATP 1.00 1.01 1.01 1.00 1.01 .98 1.02
Tpo
KLA  ATP  ATP+KLA
 NM_009417 thyroid peroxidase (Tpo), mRNA [NM_009417] KLA 1.05 1.05 .87 1.01 1.00 1.03 1.04
ATP 1.03 .95 .99 1.02 1.00 1.00 .91
KLA/ATP 1.01 .99 1.01 1.01 .93 .96 .93
Tyr
KLA  ATP  ATP+KLA
 NM_011661 tyrosinase (Tyr), mRNA [NM_011661] KLA .99 1.02 .99 1.01 1.00 1.01 1.03
ATP 1.01 .98 .99 1.03 1.00 1.01 1.00
KLA/ATP 1.01 1.00 1.00 1.01 1.00 1.03 .98
Tyrp1
KLA  ATP  ATP+KLA
 NM_031202 tyrosinase-related protein 1 (Tyrp1), mRNA [NM_031202] KLA .97 .98 1.01 .99 .99 .98 .97
ATP 1.01 .99 1.00 .97 .99 1.00 .98
KLA/ATP .98 .99 1.01 .98 .98 .97 1.00
Wbscr22
KLA  ATP  ATP+KLA
 NM_025375 Williams Beuren syndrome chromosome region 22 (Wbscr22), mRNA [NM_025375] KLA 1.07 1.03 1.02 1.00 1.03 .95 .95
ATP 1.14 1.21 .99 1.11 .94 .85 1.05
KLA/ATP 1.07 1.08 1.19 1.08 .80 .68 .74