Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: beta-Alanine metabolism (mmu00410)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
1700055N
04Rik
KLA  ATP  ATP+KLA
 AK081788 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130077J09 product:weakly similar to ALDEHYDE DEHYDROGENASE 7 (EC 1.2.1.5) [Homo sapiens], full insert sequence [AK081788] KLA .96 .98 .95 .97 .97 .96 1.06
ATP 1.01 1.00 .97 1.10 .95 .99 1.02
KLA/ATP .99 1.00 .97 1.00 1.00 .96 .97
AI790298
KLA  ATP  ATP+KLA
 AK129347 mRNA for mKIAA1394 protein [AK129347] KLA .97 .95 .93 .98 .95 1.00 1.11
ATP .98 1.03 .98 .97 1.23 1.22 1.05
KLA/ATP .96 .99 .94 .92 1.17 1.27 1.07
Abat
KLA  ATP  ATP+KLA
 AK083062 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062] KLA 1.01 1.09 .97 .99 1.03 1.02 1.06
ATP .96 .99 1.00 1.11 1.04 .98 1.06
KLA/ATP 1.06 1.03 .96 1.06 1.10 1.06 .96
Abat
KLA  ATP  ATP+KLA
 NM_172961 4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961] KLA 1.03 .96 .97 1.00 .92 .97 .96
ATP .97 .93 1.07 1.04 .97 .99 .98
KLA/ATP 1.03 1.01 1.00 .98 .94 .89 .97
Acadm
KLA  ATP  ATP+KLA
 NM_007382 acyl-Coenzyme A dehydrogenase, medium chain (Acadm), nuclear gene encoding mitochondrial protein, mRNA [NM_007382] KLA .57 .50 .50 .37 .34 .34 .54
ATP 1.09 1.08 1.16 .92 .67 .43 .51
KLA/ATP .55 .56 .57 .46 .41 .36 .29
Aldh1a3
KLA  ATP  ATP+KLA
 AK086764 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930050B08 product:aldehyde dehydrogenase family 1, subfamily A3, full insert sequence. [AK086764] KLA .97 1.05 1.05 1.01 1.00 .98 .97
ATP 1.00 1.03 .99 .92 1.01 1.09 1.02
KLA/ATP 1.01 .99 1.06 1.00 .97 .98 1.00
Aldh1a3
KLA  ATP  ATP+KLA
 NM_053080 aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), mRNA [NM_053080] KLA 1.03 .96 1.03 1.03 .96 .98 1.01
ATP .98 1.04 1.01 1.06 .98 1.01 1.08
KLA/ATP 1.02 1.00 1.02 .94 1.03 .99 .99
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a1
KLA  ATP  ATP+KLA
 NM_007436 aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1), transcript variant 1, mRNA [NM_007436] KLA .98 .98 1.03 1.01 1.03 1.04 .97
ATP .98 1.01 1.06 .95 1.00 .96 1.02
KLA/ATP 1.07 1.08 .99 .98 1.03 .93 .98
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Aldh3b1
KLA  ATP  ATP+KLA
 NM_026316 aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), mRNA [NM_026316] KLA .82 .77 .69 .77 .72 .97 1.31
ATP .88 .85 1.13 .89 .71 .56 1.25
KLA/ATP .66 .72 .84 .66 .66 .52 1.17
Aldh3b2
KLA  ATP  ATP+KLA
 XM_129134 gb|PREDICTED: Mus musculus aldehyde dehydrogenase 3 family, member B2 (Aldh3b2), mRNA [XM_129134] KLA .91 .93 .85 .88 1.01 .99 1.37
ATP 1.12 1.11 .99 1.19 .87 .61 1.31
KLA/ATP .86 1.02 .90 1.01 .72 .54 1.21
Aldh6a1
KLA  ATP  ATP+KLA
 NM_134042 aldehyde dehydrogenase family 6, subfamily A1 (Aldh6a1), nuclear gene encoding mitochondrial protein, mRNA [NM_134042] KLA 1.02 .97 .98 1.15 1.31 1.39 .67
ATP .96 .92 1.21 .87 .64 .54 .55
KLA/ATP .82 .97 1.04 .87 .80 .59 .36
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aldh9a1
KLA  ATP  ATP+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA .64 .64 .67 .48 .42 .24 .33
ATP 1.07 1.02 .75 .94 .68 .46 .42
KLA/ATP .72 .65 .43 .55 .37 .31 .24
Aoc2
KLA  ATP  ATP+KLA
 NM_178932 amine oxidase, copper containing 2 (retina-specific) (Aoc2), mRNA [NM_178932] KLA 1.21 1.19 1.15 1.00 1.15 1.21 1.18
ATP 1.13 1.13 1.14 1.36 1.85 1.32 .76
KLA/ATP 1.27 1.34 1.12 1.32 1.67 1.37 1.05
Aoc3
KLA  ATP  ATP+KLA
 NM_009675 amine oxidase, copper containing 3 (Aoc3), mRNA [NM_009675] KLA .95 1.06 1.00 1.05 1.00 1.02 1.01
ATP 1.01 .90 1.04 1.07 1.06 1.06 .97
KLA/ATP 1.06 .98 .92 1.10 1.11 1.09 1.01
Cndp1
KLA  ATP  ATP+KLA
 NM_177450 carnosine dipeptidase 1 (metallopeptidase M20 family) (Cndp1), mRNA [NM_177450] KLA .98 1.00 1.00 1.00 .99 .93 1.04
ATP 1.02 .96 .98 .97 .97 .95 .96
KLA/ATP 1.04 1.04 .95 .94 .98 .96 .94
Cndp2
KLA  ATP  ATP+KLA
 NM_023149 CNDP dipeptidase 2 (metallopeptidase M20 family) (Cndp2), mRNA [NM_023149] KLA .88 .96 1.08 .98 1.35 1.73 1.59
ATP 1.09 1.27 .77 1.02 1.04 1.30 1.67
KLA/ATP 1.17 1.04 .63 1.09 .95 1.78 2.70
Dpyd
KLA  ATP  ATP+KLA
 NM_170778 dihydropyrimidine dehydrogenase (Dpyd), mRNA [NM_170778] KLA .94 .95 1.00 .98 .99 .98 .97
ATP 1.04 .95 1.02 1.01 1.02 1.02 .98
KLA/ATP 1.03 .98 .98 1.02 1.02 1.05 .93
Echs1
KLA  ATP  ATP+KLA
 NM_053119 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119] KLA .57 .55 .52 .54 .60 .82 .90
ATP .99 .97 1.07 1.15 .77 .37 .81
KLA/ATP .55 .56 .55 .66 .53 .39 .41
Ehhadh
KLA  ATP  ATP+KLA
 NM_023737 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737] KLA .74 .77 .80 .88 .71 .67 .74
ATP 1.02 1.06 1.04 .90 .70 .84 .83
KLA/ATP .79 .81 .80 .65 .59 .79 .55
Gad1
KLA  ATP  ATP+KLA
 AK054554 10 days neonate olfactory brain cDNA, RIKEN full-length enriched library, clone:E530004P22 product:glutamic acid decarboxylase 1, full insert sequence. [AK054554] KLA 1.03 1.00 1.00 1.00 1.00 .98 1.10
ATP 1.03 .91 1.01 1.05 .99 .97 1.08
KLA/ATP .97 .99 .99 1.10 1.02 1.09 .96
Gad1
KLA  ATP  ATP+KLA
 NM_008077 glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077] KLA 1.03 .99 1.00 1.01 1.01 .97 .99
ATP 1.02 1.02 1.01 .99 1.02 1.03 .98
KLA/ATP .96 1.03 1.04 .99 .99 1.04 1.01
Gad2
KLA  ATP  ATP+KLA
 NM_008078 glutamic acid decarboxylase 2 (Gad2), mRNA [NM_008078] KLA 1.03 1.07 1.11 1.11 1.04 .99 1.07
ATP .97 .99 1.02 1.02 1.01 .95 .97
KLA/ATP 1.05 1.08 1.04 1.01 1.00 1.06 1.00
Hadha
KLA  ATP  ATP+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA .96 .92 .91 .80 .97 .92 .90
ATP .72 .64 .63 .71 .91 .93 .93
KLA/ATP .79 .72 .68 .73 .87 .90 .88
Hadha
KLA  ATP  ATP+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00
ATP 1.16 1.22 1.03 1.40 1.09 .79 1.11
KLA/ATP 1.33 1.35 1.16 1.41 1.00 .92 1.31
Hibch
KLA  ATP  ATP+KLA
 NM_146108 3-hydroxyisobutyryl-Coenzyme A hydrolase (Hibch), mRNA [NM_146108] KLA .47 .44 .40 .33 .30 .39 .82
ATP .92 .92 1.45 1.12 .69 .61 .91
KLA/ATP .42 .41 .56 .40 .34 .45 .55
Mlycd
KLA  ATP  ATP+KLA
 NM_019966 malonyl-CoA decarboxylase (Mlycd), nuclear gene encoding mitochondrial protein, mRNA [NM_019966] KLA .77 .70 .74 .89 .75 .81 .66
ATP 1.01 .91 1.04 .78 .38 .62 .81
KLA/ATP .66 .66 .80 .56 .44 .57 .74
Mm.26684
3
KLA  ATP  ATP+KLA
 94405693 Unknown KLA 1.12 .99 .99 1.00 .97 .98 .96
ATP 1.02 1.08 1.01 .90 1.02 .97 .91
KLA/ATP 1.03 .96 .98 .91 1.05 .90 .97
Mm.34137
KLA  ATP  ATP+KLA
 94405716 Unknown KLA 1.11 1.12 1.10 1.07 1.08 1.13 1.36
ATP 1.09 1.14 1.01 1.25 .95 .79 1.23
KLA/ATP 1.01 1.24 .95 1.14 .83 .78 1.30
Sms
KLA  ATP  ATP+KLA
 NM_009214 spermine synthase (Sms), mRNA [NM_009214] KLA 1.18 1.13 1.09 1.03 .91 .68 .62
ATP .99 1.03 .86 .77 .69 .49 .56
KLA/ATP 1.08 1.13 .92 .80 .62 .42 .32
Srm
KLA  ATP  ATP+KLA
 NM_009272 spermidine synthase (Srm), mRNA [NM_009272] KLA .61 .68 .55 .41 .31 .32 .57
ATP .95 1.06 .92 1.19 .94 .50 .61
KLA/ATP .70 .65 .55 .59 .44 .26 .17
Upb1
KLA  ATP  ATP+KLA
 NM_133995 ureidopropionase, beta (Upb1), mRNA [NM_133995] KLA 1.22 1.30 1.23 1.20 1.25 1.21 1.15
ATP 1.06 1.13 1.16 1.14 1.01 1.57 1.24
KLA/ATP 1.23 1.24 1.29 1.26 1.18 1.91 2.90