Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Sphingolipid metabolism (mmu00600)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
9130409I
23Rik
KLA  ATP  ATP+KLA
 NM_001033819 RIKEN cDNA 9130409I23 gene (9130409I23Rik), mRNA [NM_001033819] KLA 1.04 .98 1.00 1.04 1.05 1.07 1.00
ATP .98 1.01 1.05 1.06 .99 .98 1.01
KLA/ATP .98 1.03 .93 1.07 1.00 1.11 .96
AK209324
KLA  ATP  ATP+KLA
 AK209324 cDNA, clone:Y2G0114L23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000060207, based on BLAT search. [AK209324] KLA .48 .51 .55 .57 .80 .90 1.17
ATP 1.01 .96 .73 .60 .76 .78 1.24
KLA/ATP .54 .46 .42 .54 .76 .76 .73
Arsa
KLA  ATP  ATP+KLA
 NM_009713 arylsulfatase A (Arsa), mRNA [NM_009713] KLA .77 .77 .76 .71 .73 .69 .79
ATP .96 .98 .94 .80 .66 .53 .92
KLA/ATP .74 .79 .71 .62 .52 .43 .59
Asah1
KLA  ATP  ATP+KLA
 NM_019734 N-acylsphingosine amidohydrolase 1 (Asah1), mRNA [NM_019734] KLA .80 .84 .84 .69 .72 .78 1.09
ATP 1.04 1.26 1.00 1.15 .82 .53 .72
KLA/ATP .87 .89 .63 .82 .51 .47 .49
Asah2
KLA  ATP  ATP+KLA
 NM_018830 N-acylsphingosine amidohydrolase 2 (Asah2), mRNA [NM_018830] KLA 1.87 2.01 2.15 1.97 1.73 1.55 1.28
ATP .94 .87 .90 .86 .68 .59 .69
KLA/ATP 1.87 1.92 1.74 1.48 1.02 .84 .87
Asah3
KLA  ATP  ATP+KLA
 NM_175731 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 (Asah3), mRNA [NM_175731] KLA 1.01 .98 .99 1.01 1.09 1.01 1.05
ATP .97 1.02 1.00 1.01 1.01 1.07 1.08
KLA/ATP .96 .97 1.05 1.04 1.05 1.01 1.07
Asah3l
KLA  ATP  ATP+KLA
 AK046888 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930001C21 product:hypothetical protein, full insert sequence. [AK046888] KLA 1.18 1.09 1.15 1.30 1.15 1.19 1.02
ATP 1.05 1.06 1.33 1.50 1.65 1.53 .99
KLA/ATP 1.29 1.32 1.73 1.71 1.67 1.54 1.41
Asah3l
KLA  ATP  ATP+KLA
 NM_139306 N-acylsphingosine amidohydrolase 3-like (Asah3l), mRNA [NM_139306] KLA 1.16 1.09 1.05 .94 .82 .89 .89
ATP 1.10 .98 1.17 3.98 4.06 2.11 1.04
KLA/ATP 1.00 1.07 1.04 2.15 2.34 2.03 1.00
B4galt6
KLA  ATP  ATP+KLA
 NM_019737 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 (B4galt6), mRNA [NM_019737] KLA .46 .48 .57 .53 .90 .96 .81
ATP 1.09 1.13 .72 .53 .18 .22 .51
KLA/ATP .56 .51 .26 .30 .15 .25 .60
Cerk
KLA  ATP  ATP+KLA
 NM_145475 ceramide kinase (Cerk), mRNA [NM_145475] KLA .27 .26 .24 .27 .38 .84 .98
ATP 1.02 .99 .88 .78 1.40 1.18 2.22
KLA/ATP .28 .26 .28 .29 1.59 1.54 2.18
Degs1
KLA  ATP  ATP+KLA
 NM_007853 degenerative spermatocyte homolog 1 (Drosophila) (Degs1), mRNA [NM_007853] KLA .83 .80 .78 .74 .58 .38 .67
ATP 1.14 1.08 1.10 1.18 1.53 1.19 .96
KLA/ATP .88 .88 .82 .78 .76 .57 .52
Degs2
KLA  ATP  ATP+KLA
 NM_027299 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase (Degs2), mRNA [NM_027299] KLA 1.03 .99 .93 .99 1.05 1.03 .94
ATP 1.00 1.02 1.05 .97 1.06 .92 .99
KLA/ATP 1.04 1.06 1.00 .93 1.00 .94 .94
Enpp7
KLA  ATP  ATP+KLA
 NM_001030291 ectonucleotide pyrophosphatase/phosphodiesterase 7 (Enpp7), mRNA [NM_001030291] KLA 1.00 1.03 1.01 1.01 .95 1.07 1.05
ATP 1.01 1.01 .99 .99 1.04 .98 1.01
KLA/ATP .96 .96 .95 .96 1.02 1.01 .99
Gal3st1
KLA  ATP  ATP+KLA
 NM_016922 galactose-3-O-sulfotransferase 1 (Gal3st1), mRNA [NM_016922] KLA 1.02 .94 .99 .97 .97 .95 .97
ATP .97 1.03 .97 1.04 1.02 .98 .96
KLA/ATP .95 1.00 .93 1.04 .96 1.01 .99
Galc
KLA  ATP  ATP+KLA
 NM_008079 galactosylceramidase (Galc), mRNA [NM_008079] KLA .70 .68 .66 .54 .40 .42 .62
ATP 1.11 1.33 1.00 1.23 .90 .72 .61
KLA/ATP .80 .80 .56 .71 .46 .53 .48
Gba
KLA  ATP  ATP+KLA
 NM_001077411 glucosidase, beta, acid (Gba), mRNA [NM_001077411] KLA .86 .89 .92 .84 .95 1.11 1.65
ATP .97 .99 .60 .74 .63 .76 2.19
KLA/ATP .95 .85 .52 .74 .50 .81 2.57
Gba2
KLA  ATP  ATP+KLA
 NM_172692 glucosidase beta 2 (Gba2), mRNA [NM_172692] KLA .43 .43 .47 .62 .82 .99 .91
ATP 1.00 1.00 .97 .81 .53 .73 1.03
KLA/ATP .41 .43 .47 .47 .69 .88 1.21
Gla
KLA  ATP  ATP+KLA
 NM_013463 galactosidase, alpha (Gla), mRNA [NM_013463] KLA .91 .95 1.02 .93 1.02 1.35 1.99
ATP 1.06 1.22 1.08 1.49 1.31 1.44 3.32
KLA/ATP 1.01 1.05 .89 1.54 1.26 1.98 5.13
Gla
KLA  ATP  ATP+KLA
 U34071 alpha-galactosidase A mRNA, complete cds. [U34071] KLA .99 .99 1.18 1.28 1.30 1.59 1.66
ATP 1.12 1.20 1.32 1.74 1.93 1.44 1.50
KLA/ATP 1.12 1.24 1.28 1.98 2.55 2.85 2.82
Glb1
KLA  ATP  ATP+KLA
 NM_009752 galactosidase, beta 1 (Glb1), mRNA [NM_009752] KLA .93 .96 1.02 .85 .86 .81 .80
ATP 1.03 1.10 1.01 1.13 .97 .82 .75
KLA/ATP 1.08 1.04 .86 1.06 .81 .81 .66
Kdsr
KLA  ATP  ATP+KLA
 NM_027534 3-ketodihydrosphingosine reductase (Kdsr), mRNA [NM_027534] KLA .54 .46 .41 .39 .38 .40 .46
ATP .98 .97 1.23 1.13 1.01 .68 .52
KLA/ATP .48 .49 .59 .69 .92 .55 .31
Lass2
KLA  ATP  ATP+KLA
 NM_029789 LAG1 homolog, ceramide synthase 2 (Lass2), mRNA [NM_029789] KLA .79 .81 .81 .68 .72 .72 1.08
ATP 1.02 1.11 .95 1.07 .94 .70 1.25
KLA/ATP .86 .86 .62 .78 .64 .63 .97
Lass4
KLA  ATP  ATP+KLA
 AK036108 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630036I10 product:longevity assurance homolog 4 (S. cerevisiae), full insert sequence. [AK036108] KLA .86 .82 .81 .76 .78 .71 .76
ATP 1.05 .97 .93 .71 .86 .79 .75
KLA/ATP .90 .81 .80 .72 .80 .74 .72
Lass4
KLA  ATP  ATP+KLA
 NM_026058 LAG1 homolog, ceramide synthase 4 (Lass4), mRNA [NM_026058] KLA .64 .61 .59 .67 .59 .56 .55
ATP .91 .92 1.09 .90 .62 .55 .61
KLA/ATP .63 .65 .73 .66 .60 .55 .55
Lass5
KLA  ATP  ATP+KLA
 NM_028015 LAG1 homolog, ceramide synthase 5 (Lass5), mRNA [NM_028015] KLA .62 .60 .53 .42 .37 .34 .66
ATP 1.05 1.15 1.02 1.21 .85 .53 .90
KLA/ATP .68 .64 .53 .54 .39 .37 .42
Lass6
KLA  ATP  ATP+KLA
 AK136463 adult male colon cDNA, RIKEN full-length enriched library, clone:9030601N10 product:unclassifiable, full insert sequence [AK136463] KLA 6.80 6.12 6.10 6.59 4.37 2.19 3.16
ATP 1.11 1.03 1.26 1.13 2.24 2.53 .84
KLA/ATP 6.23 6.58 7.50 5.95 5.29 2.64 1.33
Lass6
KLA  ATP  ATP+KLA
 NM_172856 LAG1 homolog, ceramide synthase 6 (Lass6), mRNA [NM_172856] KLA 8.82 11.21 11.49 12.30 10.83 7.97 7.15
ATP 1.11 1.13 1.22 1.58 2.13 4.41 4.45
KLA/ATP 10.82 12.09 9.72 11.37 7.17 5.10 9.51
Mm.10370
3
KLA  ATP  ATP+KLA
 118131105 Unknown KLA 1.00 1.01 .96 .80 .81 1.04 1.02
ATP .99 1.06 .98 .67 .72 .82 1.06
KLA/ATP 1.02 1.12 .94 .76 .84 1.08 .93
Mm.24411
4
KLA  ATP  ATP+KLA
 71892413 Unknown KLA .97 1.00 1.06 .95 .98 1.03 .99
ATP 1.01 1.04 1.01 .97 .98 1.00 1.05
KLA/ATP 1.05 1.00 .97 1.04 .97 1.04 .99
Mm.28873
KLA  ATP  ATP+KLA
 110431340 Unknown KLA .79 .72 .69 .71 .44 .32 .37
ATP .89 .88 1.17 .98 1.11 .98 .73
KLA/ATP .67 .72 .87 .74 .75 .53 .30
Mm.32981
0
KLA  ATP  ATP+KLA
 55741832 Unknown KLA 1.02 .84 .68 .95 1.70 .68 .70
ATP 1.13 1.06 1.48 1.46 1.40 1.58 .58
KLA/ATP .82 .80 .95 .85 .60 .70 .50
Mm.35517
4
KLA  ATP  ATP+KLA
 142352582 Unknown KLA 1.05 .97 .95 1.03 1.05 .98 .97
ATP .98 1.02 1.00 1.03 .97 1.05 1.01
KLA/ATP .98 .97 1.03 .97 1.00 1.02 .99
Mm.39818
1
KLA  ATP  ATP+KLA
 9790036 Unknown KLA .48 .51 .55 .56 .86 1.00 .82
ATP .99 1.00 .70 .48 .19 .24 .54
KLA/ATP .57 .48 .28 .29 .18 .29 .63
Neu1
KLA  ATP  ATP+KLA
 NM_010893 neuraminidase 1 (Neu1), mRNA [NM_010893] KLA .59 .58 .57 .66 .88 1.30 1.59
ATP .98 1.01 1.08 1.31 1.76 2.01 2.47
KLA/ATP .57 .59 .70 .78 1.18 1.73 2.99
Neu2
KLA  ATP  ATP+KLA
 NM_015750 neuraminidase 2 (Neu2), mRNA [NM_015750] KLA 1.07 1.16 1.12 1.24 1.18 1.16 1.17
ATP 1.13 1.11 1.15 1.12 1.08 1.07 1.05
KLA/ATP 1.14 1.22 1.22 1.19 1.11 1.12 1.09
Neu3
KLA  ATP  ATP+KLA
 NM_016720 neuraminidase 3 (Neu3), mRNA [NM_016720] KLA 1.09 1.07 1.02 .92 .82 1.10 1.08
ATP .99 .87 1.06 .72 .82 .92 1.05
KLA/ATP 1.08 1.04 1.02 .86 .94 1.24 1.02
Neu4
KLA  ATP  ATP+KLA
 NM_173772 sialidase 4 (Neu4), mRNA [NM_173772] KLA 1.00 .97 1.03 1.05 1.03 1.04 .99
ATP 1.03 .99 .98 1.02 1.02 1.02 .90
KLA/ATP .92 1.06 1.03 .98 1.04 .95 1.06
Phca
KLA  ATP  ATP+KLA
 NM_025408 phytoceramidase, alkaline (Phca), mRNA [NM_025408] KLA 1.35 1.37 1.51 1.45 1.24 .87 .74
ATP 1.07 1.13 1.20 .99 .84 .56 .79
KLA/ATP 1.21 1.36 1.66 1.53 1.19 .76 .73
Ppap2a
KLA  ATP  ATP+KLA
 NM_008903 phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 2.62 2.86 4.01 5.61 7.84 10.88 16.35
ATP 1.01 1.02 1.09 1.28 1.27 2.38 1.44
KLA/ATP 2.78 2.78 2.99 3.43 2.85 3.59 6.59
Ppap2b
KLA  ATP  ATP+KLA
 NM_080555 phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 2.73 2.72 2.65 2.39 1.07 1.48 3.26
ATP .99 .97 1.60 2.76 18.64 27.23 9.19
KLA/ATP 2.69 2.80 4.36 4.20 14.33 15.32 17.91
Ppap2c
KLA  ATP  ATP+KLA
 NM_015817 phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA .94 .88 .91 .79 .65 .46 .51
ATP 1.01 1.03 1.00 1.12 1.24 .90 .83
KLA/ATP .95 .93 .87 .95 .79 .63 .43
Sgms1
KLA  ATP  ATP+KLA
 NM_144792 sphingomyelin synthase 1 (Sgms1), mRNA [NM_144792] KLA .84 .84 .58 .94 1.49 .66 .71
ATP .98 .97 1.57 1.85 1.32 1.60 .57
KLA/ATP .82 .73 .90 .97 .67 .81 .55
Sgms2
KLA  ATP  ATP+KLA
 NM_028943 sphingomyelin synthase 2 (Sgms2), mRNA [NM_028943] KLA 1.21 1.19 1.18 1.03 .89 .92 1.42
ATP 1.00 .99 1.08 1.22 3.11 11.82 3.08
KLA/ATP 1.17 1.16 1.07 1.21 1.17 3.37 5.49
Sgpl1
KLA  ATP  ATP+KLA
 NM_009163 sphingosine phosphate lyase 1 (Sgpl1), mRNA [NM_009163] KLA .89 .84 .89 .90 .84 .86 1.09
ATP 1.17 1.14 .75 .82 1.35 1.57 1.75
KLA/ATP 1.01 .97 .64 .82 1.08 1.45 1.97
Sgpp1
KLA  ATP  ATP+KLA
 AK043586 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830010K07 product:sphingosine-1-phosphate phosphatase 1, full insert sequence. [AK043586] KLA .93 .91 .96 .90 .91 .92 .91
ATP 1.01 .97 .98 .88 .97 .96 .84
KLA/ATP .88 1.05 .94 .98 .98 .98 .91
Sgpp1
KLA  ATP  ATP+KLA
 NM_030750 sphingosine-1-phosphate phosphatase 1 (Sgpp1), mRNA [NM_030750] KLA .52 .52 .68 .72 1.14 .87 .41
ATP 1.19 1.37 1.16 1.14 .65 .37 .46
KLA/ATP .60 .52 .49 .69 .52 .42 .24
Sgpp2
KLA  ATP  ATP+KLA
 AK087798 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330022I10 product:unclassifiable, full insert sequence [AK087798] KLA 1.04 1.05 1.02 1.02 .96 .94 .97
ATP 1.00 1.05 1.05 1.04 1.01 1.01 1.00
KLA/ATP .96 1.02 1.06 1.01 1.00 .99 .96
Sgpp2
KLA  ATP  ATP+KLA
 NM_001004173 sphingosine-1-phosphate phosphotase 2 (Sgpp2), mRNA [NM_001004173] KLA .98 .96 1.00 1.02 .96 1.08 1.01
ATP .97 1.02 1.01 1.00 1.01 1.05 1.05
KLA/ATP .98 1.00 .98 1.05 .96 1.02 .97
Smpd1
KLA  ATP  ATP+KLA
 NM_011421 sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1), mRNA [NM_011421] KLA .68 .66 .67 .87 .91 1.01 1.11
ATP 1.04 1.02 1.06 1.03 1.02 1.30 1.73
KLA/ATP .69 .68 .86 .71 .78 .99 1.64
Smpd2
KLA  ATP  ATP+KLA
 NM_009213 sphingomyelin phosphodiesterase 2, neutral (Smpd2), mRNA [NM_009213] KLA .56 .61 .60 .55 .63 .74 .65
ATP .94 .87 .63 .65 .65 .69 .82
KLA/ATP .62 .59 .56 .47 .73 .79 .65
Smpd3
KLA  ATP  ATP+KLA
 NM_021491 sphingomyelin phosphodiesterase 3, neutral (Smpd3), mRNA [NM_021491] KLA .58 .60 .50 .51 .40 .41 .48
ATP 1.08 1.03 .97 .91 .56 .42 .79
KLA/ATP .57 .59 .58 .59 .47 .44 .56
Smpd4
KLA  ATP  ATP+KLA
 AK164456 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230040E22 product:similar to Hypothetical P-loop containing nucleotide triphosphate hydrolases structure containing protein [Mus musculus], full insert sequence [AK16 KLA .90 .91 .87 .80 .81 .75 .75
ATP 1.01 1.10 1.04 .99 1.03 .84 .41
KLA/ATP .93 .94 .83 .88 .84 .75 .35
Smpd4
KLA  ATP  ATP+KLA
 NM_029945 sphingomyelin phosphodiesterase 4 (Smpd4), mRNA [NM_029945] KLA .98 .97 .97 .94 1.00 1.01 1.02
ATP .97 1.06 .98 1.01 .77 .74 .93
KLA/ATP .94 1.02 .87 1.01 .69 .71 .87
Sphk1
KLA  ATP  ATP+KLA
 NM_025367 sphingosine kinase 1 (Sphk1), transcript variant 2, mRNA [NM_025367] KLA 2.61 2.50 2.04 1.71 1.19 .91 .74
ATP .94 1.00 2.06 8.09 16.52 12.59 3.53
KLA/ATP 2.64 2.81 3.50 8.13 23.71 16.46 2.22
Sphk2
KLA  ATP  ATP+KLA
 NM_020011 sphingosine kinase 2 (Sphk2), transcript variant 2, mRNA [NM_020011] KLA .64 .74 1.05 1.47 2.15 1.84 1.67
ATP 1.10 1.02 .57 .54 .49 1.29 2.15
KLA/ATP .78 .64 .43 .56 .86 1.90 3.74
Sptlc1
KLA  ATP  ATP+KLA
 NM_009269 serine palmitoyltransferase, long chain base subunit 1 (Sptlc1), mRNA [NM_009269] KLA 1.34 1.32 1.35 1.36 1.26 1.30 1.31
ATP .98 1.04 1.06 1.00 .76 1.02 1.57
KLA/ATP 1.27 1.44 1.37 1.27 .91 1.12 1.57
Sptlc2
KLA  ATP  ATP+KLA
 NM_011479 serine palmitoyltransferase, long chain base subunit 2 (Sptlc2), mRNA [NM_011479] KLA 2.03 2.10 2.53 2.42 2.17 1.88 1.45
ATP 1.08 1.10 1.17 1.27 2.52 4.23 1.87
KLA/ATP 2.17 2.37 2.54 2.82 3.28 4.03 2.41
Sptlc3
KLA  ATP  ATP+KLA
 NM_175467 serine palmitoyltransferase, long chain base subunit 3 (Sptlc3), mRNA [NM_175467] KLA 1.22 1.31 1.26 1.25 1.20 1.17 1.12
ATP .95 1.03 1.02 .94 1.16 1.40 1.32
KLA/ATP 1.11 1.18 1.28 1.30 1.20 1.22 1.31
Ugcg
KLA  ATP  ATP+KLA
 BC050828 UDP-glucose ceramide glucosyltransferase, mRNA (cDNA clone MGC:59317 IMAGE:6512920), complete cds [BC050828] KLA 3.14 2.80 2.93 3.01 1.88 1.45 1.73
ATP 1.22 1.28 1.11 1.66 6.31 4.52 1.39
KLA/ATP 3.05 3.59 2.52 3.22 4.86 5.40 2.39
Ugcg
KLA  ATP  ATP+KLA
 NM_011673 UDP-glucose ceramide glucosyltransferase (Ugcg), mRNA [NM_011673] KLA 2.82 2.78 2.92 2.52 1.85 1.64 1.75
ATP 1.04 1.22 1.55 2.42 5.88 4.88 1.65
KLA/ATP 3.05 3.21 3.10 3.92 5.18 5.21 2.64
Ugt8a
KLA  ATP  ATP+KLA
 NM_011674 UDP galactosyltransferase 8A (Ugt8a), mRNA [NM_011674] KLA 1.02 1.04 1.04 1.00 .98 1.08 1.00
ATP .98 1.02 1.01 1.02 1.00 1.07 1.07
KLA/ATP .98 1.06 1.04 .94 1.02 .99 1.04