Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: One carbon pool by folate (mmu00670)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Aldh1l1
KLA  ATP  ATP+KLA
 NM_027406 aldehyde dehydrogenase 1 family, member L1 (Aldh1l1), mRNA [NM_027406] KLA 1.29 1.44 1.65 1.63 1.95 2.02 .98
ATP 1.11 1.14 .93 1.01 .74 .32 .76
KLA/ATP 1.52 1.51 1.28 1.56 .93 .67 .77
Aldh1l2
KLA  ATP  ATP+KLA
 NM_153543 aldehyde dehydrogenase 1 family, member L2 (Aldh1l2), mRNA [NM_153543] KLA 1.02 1.03 1.06 .99 .97 1.01 .93
ATP 1.02 .99 1.01 .95 .96 .96 .96
KLA/ATP 1.04 1.00 .93 .91 .90 .98 .95
Atic
KLA  ATP  ATP+KLA
 NM_026195 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic), mRNA [NM_026195] KLA .86 .91 .91 .70 .63 .49 .77
ATP 1.16 1.33 1.00 1.41 .87 .41 .59
KLA/ATP 1.07 1.15 .70 1.01 .57 .31 .26
Dhfr
KLA  ATP  ATP+KLA
 L26316 dihydrofolate reductase (dhfr) mRNA, complete cds. [L26316] KLA .63 .69 .61 .62 .53 .57 .45
ATP .93 .93 1.10 1.12 .84 .49 .39
KLA/ATP .66 .59 .72 .74 .67 .65 .90
Dhfr
KLA  ATP  ATP+KLA
 NM_010049 dihydrofolate reductase (Dhfr), mRNA [NM_010049] KLA .52 .51 .48 .47 .39 .49 .33
ATP .90 .90 1.13 1.05 .76 .40 .28
KLA/ATP .46 .48 .58 .59 .59 .57 .68
Ftcd
KLA  ATP  ATP+KLA
 NM_080845 formiminotransferase cyclodeaminase (Ftcd), mRNA [NM_080845] KLA 1.01 .93 .98 .93 .99 1.06 1.05
ATP 1.01 1.00 .96 .96 .95 .93 1.04
KLA/ATP 1.00 .99 .99 .97 .98 .92 .93
Gart
KLA  ATP  ATP+KLA
 AK168445 13 days embryo liver cDNA, RIKEN full-length enriched library, clone:I920021A03 product:phosphoribosylglycinamide formyltransferase, full insert sequence. [AK168445] KLA .88 .80 .73 .71 .52 .48 .75
ATP 1.03 .98 1.11 1.02 .61 .37 .52
KLA/ATP .81 .86 .87 .75 .49 .30 .26
Gart
KLA  ATP  ATP+KLA
 NM_010256 phosphoribosylglycinamide formyltransferase (Gart), mRNA [NM_010256] KLA .68 .73 .60 .50 .46 .57 .70
ATP .97 1.03 .93 .91 .59 .39 .58
KLA/ATP .69 .70 .58 .59 .39 .32 .33
LOC10003
9707
KLA  ATP  ATP+KLA
 XM_001473273 gb|PREDICTED: Mus musculus similar to 5, 10-methenyltetrahydrofolate synthetase (LOC100039707), mRNA [XM_001473273] KLA 1.15 1.22 1.34 1.10 1.24 .99 .95
ATP 1.05 1.05 1.00 1.00 .97 .91 .81
KLA/ATP 1.23 1.38 1.14 1.17 .91 .93 .86
Mm.15303
0
KLA  ATP  ATP+KLA
 124301197 Unknown KLA 1.07 1.01 1.05 1.02 .67 .60 .91
ATP .89 .85 1.38 1.28 1.54 1.92 .73
KLA/ATP .90 1.00 1.20 1.05 .93 .58 .57
Mm.29584
KLA  ATP  ATP+KLA
 20270274 Unknown KLA .71 .64 .54 .49 .33 .33 .49
ATP .84 .85 1.28 1.02 .82 .39 .47
KLA/ATP .57 .64 .77 .60 .52 .30 .19
Mtfmt
KLA  ATP  ATP+KLA
 NM_027134 mitochondrial methionyl-tRNA formyltransferase (Mtfmt), nuclear gene encoding mitochondrial protein, mRNA [NM_027134] KLA .87 .84 .86 .93 .93 1.02 .98
ATP .88 .89 .83 .32 .86 1.29 .97
KLA/ATP .80 .80 .85 .33 1.01 1.28 .95
Mthfd1
KLA  ATP  ATP+KLA
 NM_138745 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase (Mthfd1), mRNA [NM_138745] KLA .69 .68 .59 .46 .33 .31 .53
ATP .94 1.07 1.11 1.21 .84 .34 .48
KLA/ATP .68 .71 .64 .66 .44 .25 .17
Mthfd1l
KLA  ATP  ATP+KLA
 NM_172308 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l), mRNA [NM_172308] KLA .86 .88 .73 .64 .50 .40 .50
ATP .97 .99 1.19 1.03 .96 .86 .32
KLA/ATP .88 .86 .84 .74 .78 .65 .20
Mthfd2
KLA  ATP  ATP+KLA
 NM_008638 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (Mthfd2), nuclear gene encoding mitochondrial protein, mRNA [NM_008638] KLA 1.72 1.73 1.41 1.61 2.15 3.05 3.45
ATP 1.13 1.16 .97 1.23 2.55 2.27 2.28
KLA/ATP 1.42 1.75 1.68 1.84 2.13 2.41 2.12
Mthfr
KLA  ATP  ATP+KLA
 AF404274 methylenetetrahydrofolate reductase short isoform (Mthfr) mRNA, partial cds; alternatively spliced. [AF404274] KLA 1.05 .94 .98 .99 .96 1.03 1.08
ATP .94 1.00 .96 1.01 .96 .84 1.11
KLA/ATP .93 .99 .95 1.05 1.01 .99 1.08
Mthfr
KLA  ATP  ATP+KLA
 NM_010840 5,10-methylenetetrahydrofolate reductase (Mthfr), mRNA [NM_010840] KLA 5.09 5.09 6.32 5.94 6.76 6.97 3.52
ATP .98 .92 .91 .80 1.52 3.30 4.30
KLA/ATP 5.03 4.79 4.71 3.89 5.46 7.22 9.94
Mthfs
KLA  ATP  ATP+KLA
 NM_026829 5, 10-methenyltetrahydrofolate synthetase (Mthfs), mRNA [NM_026829] KLA 1.92 1.98 2.10 1.90 1.83 1.41 1.00
ATP .96 .96 1.23 1.33 1.21 .86 1.66
KLA/ATP 2.00 2.22 2.99 2.93 2.57 1.51 1.32
Mtr
KLA  ATP  ATP+KLA
 AK037599 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130029B16 product:5-methyltetrahydrofolate-homocysteine methyltransferase, full insert sequence. [AK037599] KLA .89 .92 .81 .83 .73 .76 .98
ATP .98 1.11 .85 .93 .68 .72 1.12
KLA/ATP .92 .93 .71 .85 .66 .68 .77
Mtr
KLA  ATP  ATP+KLA
 NM_001081128 5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA [NM_001081128] KLA .93 .91 .89 .77 .64 .58 .99
ATP 1.12 1.11 1.05 .87 .71 .69 1.59
KLA/ATP 1.02 .95 .96 .78 .54 .55 .92
Shmt1
KLA  ATP  ATP+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA .85 .89 .82 .83 .82 .88 .83
ATP .93 .81 .85 .82 .85 .86 .72
KLA/ATP .81 .83 .91 .86 .85 .86 .72
Shmt2
KLA  ATP  ATP+KLA
 NM_028230 serine hydroxymethyltransferase 2 (mitochondrial) (Shmt2), nuclear gene encoding mitochondrial protein, mRNA [NM_028230] KLA .82 .90 .78 .63 .51 .39 .63
ATP 1.04 1.21 .97 1.44 1.32 .85 .64
KLA/ATP .94 .92 .62 1.01 .59 .49 .32
Tyms
KLA  ATP  ATP+KLA
 NM_021288 thymidylate synthase (Tyms), mRNA [NM_021288] KLA .82 .81 .75 .71 .48 .30 .16
ATP 1.00 .94 1.32 1.26 .91 .52 .18
KLA/ATP .77 .73 1.07 .96 .80 .38 .18
Tyms
KLA  ATP  ATP+KLA
 X14489 gb|M.musculus thymidylate synthase (TS) gene exons 5 - 7. [X14489] KLA .87 .84 .91 .93 .93 .94 .77
ATP .99 .93 .95 .91 .94 .83 .79
KLA/ATP .87 .89 .92 .82 .85 .87 .85