Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Notch signaling pathway (mmu04330)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
1700023B
02Rik
KLA  ATP  ATP+KLA
 NM_025854 RIKEN cDNA 1700023B02 gene (1700023B02Rik), mRNA [NM_025854] KLA .71 .72 .76 .93 .80 .93 .94
ATP .95 .89 1.16 .97 .69 1.08 .91
KLA/ATP .67 .70 .94 .74 .81 1.07 1.16
Adam17
KLA  ATP  ATP+KLA
 NM_009615 a disintegrin and metallopeptidase domain 17 (Adam17), mRNA [NM_009615] KLA 2.32 2.42 2.15 2.20 2.08 1.87 1.57
ATP .94 1.04 1.01 1.27 1.14 .93 .84
KLA/ATP 2.27 2.57 2.18 2.03 1.49 1.00 1.07
Aph1a
KLA  ATP  ATP+KLA
 NM_146104 anterior pharynx defective 1a homolog (C. elegans) (Aph1a), mRNA [NM_146104] KLA 1.27 1.41 1.26 1.55 1.31 1.67 1.30
ATP 1.12 1.45 1.02 1.27 1.02 1.07 .91
KLA/ATP 1.52 1.57 1.46 1.15 1.01 1.02 1.54
Aph1b
KLA  ATP  ATP+KLA
 NM_177583 anterior pharynx defective 1b homolog (C. elegans) (Aph1b), mRNA [NM_177583] KLA .35 .35 .32 .32 .34 .46 .69
ATP .95 .88 1.02 1.54 2.14 1.05 1.09
KLA/ATP .35 .35 .58 1.49 3.37 1.54 .84
Aph1c
KLA  ATP  ATP+KLA
 NM_026674 anterior pharynx defective 1c homolog (C. elegans) (Aph1c), mRNA [NM_026674] KLA .36 .34 .31 .36 .35 .46 .51
ATP .92 .88 1.33 2.14 3.08 .86 1.14
KLA/ATP .34 .39 .73 1.17 2.95 1.32 .61
Crebbp
KLA  ATP  ATP+KLA
 AK048818 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230072N21 product:hypothetical protein, full insert sequence [AK048818] KLA 1.44 1.19 1.26 1.25 1.25 1.36 1.24
ATP .98 .90 1.04 1.11 1.95 2.72 1.51
KLA/ATP 1.17 1.27 1.45 1.28 1.98 2.80 2.52
Crebbp
KLA  ATP  ATP+KLA
 NM_001025432 CREB binding protein (Crebbp), mRNA [NM_001025432] KLA .97 1.01 .98 1.06 1.05 .99 1.07
ATP 1.07 1.05 .96 1.01 1.15 1.14 1.00
KLA/ATP 1.01 .97 .97 1.00 1.03 1.23 1.13
Crebbp
KLA  ATP  ATP+KLA
 S66385 gb|CREB-binding protein [mice, brain, mRNA Partial, 7326 nt]. [S66385] KLA 1.00 .98 1.08 .98 1.04 1.07 1.08
ATP .99 .98 .99 1.09 1.13 1.08 1.05
KLA/ATP 1.06 1.00 1.05 1.03 1.02 1.14 1.11
Ctbp1
KLA  ATP  ATP+KLA
 NM_013502 C-terminal binding protein 1 (Ctbp1), mRNA [NM_013502] KLA .77 .77 .71 .65 .67 .65 .95
ATP .89 .84 .42 .45 .45 .71 .80
KLA/ATP .73 .65 .30 .34 .34 .64 .61
Ctbp2
KLA  ATP  ATP+KLA
 NM_009980 C-terminal binding protein 2 (Ctbp2), mRNA [NM_009980] KLA .59 .57 .49 .44 .44 .60 .85
ATP .91 .87 .75 .79 .72 .89 .96
KLA/ATP .60 .50 .41 .45 .54 .63 .71
Dll1
KLA  ATP  ATP+KLA
 NM_007865 delta-like 1 (Drosophila) (Dll1), mRNA [NM_007865] KLA 10.19 9.27 8.97 6.41 3.44 2.99 1.51
ATP 1.01 1.01 1.21 1.43 1.44 1.64 1.23
KLA/ATP 9.24 10.74 7.35 6.56 5.63 4.14 2.19
Dll3
KLA  ATP  ATP+KLA
 NM_007866 delta-like 3 (Drosophila) (Dll3), mRNA [NM_007866] KLA 1.00 1.01 1.04 1.04 1.10 .97 1.04
ATP 1.02 1.03 .98 1.04 1.01 1.04 .95
KLA/ATP .97 1.02 .96 1.05 1.00 1.14 1.01
Dll4
KLA  ATP  ATP+KLA
 NM_019454 delta-like 4 (Drosophila) (Dll4), mRNA [NM_019454] KLA 1.02 1.02 .97 1.07 1.09 1.13 1.02
ATP 1.04 1.07 1.04 .97 1.07 1.11 1.05
KLA/ATP .98 1.11 1.08 1.11 1.18 1.18 1.04
Dtx1
KLA  ATP  ATP+KLA
 NM_008052 deltex 1 homolog (Drosophila) (Dtx1), mRNA [NM_008052] KLA 1.07 1.14 1.06 1.13 1.10 1.08 .89
ATP 1.11 1.20 .99 1.17 1.03 1.09 1.04
KLA/ATP .97 1.06 1.22 1.07 1.21 1.60 1.33
Dtx2
KLA  ATP  ATP+KLA
 NM_023742 deltex 2 homolog (Drosophila) (Dtx2), mRNA [NM_023742] KLA 4.05 4.11 5.47 7.68 8.94 7.35 6.94
ATP .97 .95 .72 .87 4.36 6.39 2.45
KLA/ATP 4.08 3.95 3.27 5.42 9.96 10.03 11.32
Dtx3
KLA  ATP  ATP+KLA
 NM_030714 deltex 3 homolog (Drosophila) (Dtx3), mRNA [NM_030714] KLA .79 .84 .75 .70 .72 .70 .62
ATP 1.10 1.34 .74 1.08 .81 .70 1.57
KLA/ATP .94 .89 .61 .82 .61 .63 1.17
Dtx4
KLA  ATP  ATP+KLA
 NM_172442 deltex 4 homolog (Drosophila) (Dtx4), mRNA [NM_172442] KLA .49 .45 .43 .45 .53 .60 1.02
ATP .90 .75 .57 .65 1.16 1.35 1.11
KLA/ATP .48 .39 .37 .60 .68 .55 .58
Dvl1
KLA  ATP  ATP+KLA
 NM_010091 dishevelled, dsh homolog 1 (Drosophila) (Dvl1), mRNA [NM_010091] KLA .93 .91 .86 .74 .70 .80 1.05
ATP 1.01 1.01 .91 .91 .98 1.10 1.02
KLA/ATP 1.00 .93 .79 .82 .81 .85 1.06
Dvl2
KLA  ATP  ATP+KLA
 NM_007888 dishevelled 2, dsh homolog (Drosophila) (Dvl2), mRNA [NM_007888] KLA .49 .52 .48 .53 .52 .67 .75
ATP 1.08 1.08 .76 .93 1.47 .89 1.20
KLA/ATP .57 .47 .40 .61 1.37 .91 .92
Dvl3
KLA  ATP  ATP+KLA
 NM_007889 dishevelled 3, dsh homolog (Drosophila) (Dvl3), mRNA [NM_007889] KLA 1.08 1.09 1.05 1.18 1.11 1.10 1.11
ATP 1.00 1.01 1.05 1.05 .99 1.10 1.15
KLA/ATP 1.12 1.07 1.09 1.09 1.06 1.15 1.09
Ep300
KLA  ATP  ATP+KLA
 AK042627 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730011L11 product:P300 TRANSCRIPTION COACTIVATOR (FRAGMENT) homolog [Mus sp], full insert sequence. [AK042627] KLA 1.02 .95 .92 1.04 1.01 1.00 1.05
ATP 1.06 .89 .88 .89 1.00 .90 1.07
KLA/ATP 1.10 1.02 .87 .91 1.04 .97 .98
Ep300
KLA  ATP  ATP+KLA
 NM_177821 E1A binding protein p300 (Ep300), mRNA [NM_177821] KLA 1.61 1.26 1.57 1.38 1.78 1.41 1.40
ATP 1.34 1.60 1.11 1.08 1.16 1.05 1.15
KLA/ATP 1.86 1.94 1.18 1.56 1.71 1.42 2.05
Gcn5l2
KLA  ATP  ATP+KLA
 NM_020004 GCN5 general control of amino acid synthesis-like 2 (yeast) (Gcn5l2), transcript variant 1, mRNA [NM_020004] KLA .86 .86 .77 .82 .91 .97 1.10
ATP 1.13 1.27 1.06 1.44 .73 .63 .90
KLA/ATP 1.02 1.05 .82 1.05 .54 .62 .69
Hdac1
KLA  ATP  ATP+KLA
 U80780 putative histone deacetylase (HD1) mRNA, partial cds [U80780] KLA 2.59 2.39 2.48 2.74 3.36 2.56 1.22
ATP 1.13 1.26 1.18 1.08 .85 1.29 1.15
KLA/ATP 2.15 2.27 2.64 2.57 1.78 1.89 2.31
Hdac2
KLA  ATP  ATP+KLA
 AK051753 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130072G11 product:histone deacetylase 2, full insert sequence [AK051753] KLA .97 .97 .90 .96 1.02 .93 .96
ATP 1.02 1.03 .98 .96 .96 .90 1.05
KLA/ATP 1.00 .96 .87 .99 .92 1.00 .95
Hdac2
KLA  ATP  ATP+KLA
 NM_008229 histone deacetylase 2 (Hdac2), mRNA [NM_008229] KLA 1.27 1.35 1.33 1.18 1.03 .75 1.10
ATP .95 1.05 .79 .96 .82 .85 .81
KLA/ATP 1.28 1.43 .93 1.10 .82 .73 .60
Hes1
KLA  ATP  ATP+KLA
 NM_008235 hairy and enhancer of split 1 (Drosophila) (Hes1), mRNA [NM_008235] KLA .96 1.00 1.02 .93 1.01 .94 .99
ATP .93 1.03 1.05 .96 1.06 1.02 1.02
KLA/ATP .97 .93 1.03 1.06 1.10 1.17 1.16
Hes5
KLA  ATP  ATP+KLA
 NM_010419 hairy and enhancer of split 5 (Drosophila) (Hes5), mRNA [NM_010419] KLA .97 .99 1.01 .97 .98 .99 1.04
ATP 1.00 .92 .98 1.06 1.00 1.04 .99
KLA/ATP 1.00 1.00 .95 .93 .94 .97 1.02
Jag1
KLA  ATP  ATP+KLA
 NM_013822 jagged 1 (Jag1), mRNA [NM_013822] KLA .81 .79 .65 .68 1.01 1.70 2.27
ATP 1.03 1.06 .86 1.06 3.66 2.51 3.02
KLA/ATP .78 .76 .74 .85 1.26 1.66 2.19
Jag2
KLA  ATP  ATP+KLA
 NM_010588 jagged 2 (Jag2), mRNA [NM_010588] KLA .57 .65 .61 .66 .55 .55 .36
ATP 1.09 1.07 1.82 1.91 1.02 .68 .36
KLA/ATP .63 .64 .85 .66 .67 .64 .40
Lfng
KLA  ATP  ATP+KLA
 NM_008494 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Lfng), mRNA [NM_008494] KLA .53 .56 .48 .51 .59 .70 .88
ATP 1.15 1.25 1.22 2.82 1.68 .58 1.00
KLA/ATP .60 .51 .60 1.51 1.11 .52 .54
Maml1
KLA  ATP  ATP+KLA
 NM_175334 mastermind like 1 (Drosophila) (Maml1), mRNA [NM_175334] KLA .88 .87 .92 .95 1.39 1.28 1.36
ATP 1.21 1.32 .91 1.16 1.28 1.20 1.22
KLA/ATP .88 .97 .64 .93 1.13 1.38 2.18
Maml2
KLA  ATP  ATP+KLA
 AK040022 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430045K06 product:hypothetical Type I antifreeze protein containing protein, full insert sequence. [AK040022] KLA 1.89 1.92 1.95 1.92 1.56 1.28 1.19
ATP .95 .95 1.19 1.17 1.27 1.54 1.25
KLA/ATP 1.80 1.92 1.82 1.62 1.32 1.30 1.21
Maml2
KLA  ATP  ATP+KLA
 XM_001481278 gb|PREDICTED: Mus musculus mastermind like 2 (Drosophila) (Maml2), mRNA [XM_001481278] KLA 3.56 3.34 3.60 2.19 1.53 1.02 .86
ATP 1.01 1.08 1.01 1.06 .99 .91 .94
KLA/ATP 3.87 3.51 2.43 3.11 1.22 .83 .76
Maml3
KLA  ATP  ATP+KLA
 NM_001004176 mastermind like 3 (Drosophila) (Maml3), mRNA [NM_001004176] KLA .93 .94 .81 .78 .71 .86 .91
ATP .95 1.03 .97 1.04 .89 .81 .91
KLA/ATP .95 .90 .79 .83 .81 .85 .89
Mfng
KLA  ATP  ATP+KLA
 NM_008595 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Mfng), mRNA [NM_008595] KLA .54 .59 .50 .53 .49 .53 .62
ATP .91 .85 .66 .67 .49 .46 .38
KLA/ATP .53 .50 .50 .57 .54 .48 .38
Mm.12896
KLA  ATP  ATP+KLA
 116292183 Unknown KLA 1.04 .94 1.01 .99 .98 .95 1.03
ATP .91 1.08 1.05 .96 .95 1.03 .99
KLA/ATP 1.01 .97 1.00 .99 1.05 .96 1.06
Mm.21517
3
KLA  ATP  ATP+KLA
 6755215 Unknown KLA 1.07 1.05 1.04 1.01 .97 1.06 .93
ATP 1.03 1.00 1.00 1.11 1.07 1.02 1.04
KLA/ATP .99 1.02 .96 .97 .98 1.04 1.11
Mm.25401
7
KLA  ATP  ATP+KLA
 134288852 Unknown KLA 6.34 5.36 6.08 5.24 3.13 1.46 1.16
ATP .93 .83 1.19 .99 2.79 3.68 1.03
KLA/ATP 5.46 5.61 8.68 4.23 2.95 2.17 1.52
Mm.28422
9
KLA  ATP  ATP+KLA
 118129861 Unknown KLA .31 .32 .31 .34 .32 .45 .46
ATP .91 .84 1.34 2.19 3.32 .85 1.09
KLA/ATP .29 .36 .71 1.21 3.18 1.42 .61
Mm.33085
0
KLA  ATP  ATP+KLA
 190684662 Unknown KLA .71 .70 .67 .78 .82 1.24 2.60
ATP .97 .98 1.16 1.09 .97 .72 1.09
KLA/ATP .72 .73 .82 .77 1.12 1.23 1.73
Mm.40558
1
KLA  ATP  ATP+KLA
 61098004 Unknown KLA .69 .67 .60 .55 .42 .45 .67
ATP .93 1.05 .95 1.28 .89 .48 .82
KLA/ATP .72 .66 .50 .53 .46 .56 .83
Mm.998
KLA  ATP  ATP+KLA
 118130584 Unknown KLA 1.14 1.17 1.21 1.06 1.22 1.16 1.13
ATP 1.02 1.07 1.06 .97 .92 1.01 .98
KLA/ATP 1.05 1.17 1.22 1.24 1.13 1.07 1.12
Ncor2
KLA  ATP  ATP+KLA
 NM_011424 nuclear receptor co-repressor 2 (Ncor2), mRNA [NM_011424] KLA .39 .37 .36 .35 .60 .99 .99
ATP 1.10 1.20 1.08 1.26 .64 .61 1.07
KLA/ATP .45 .41 .39 .44 .37 .63 .95
Ncstn
KLA  ATP  ATP+KLA
 NM_021607 nicastrin (Ncstn), mRNA [NM_021607] KLA 1.32 1.33 1.55 1.44 1.65 1.73 1.88
ATP 1.25 1.52 1.00 1.61 1.04 .95 1.64
KLA/ATP 1.68 1.55 .95 1.87 .82 1.05 2.33
Notch1
KLA  ATP  ATP+KLA
 NM_008714 Notch gene homolog 1 (Drosophila) (Notch1), mRNA [NM_008714] KLA 7.88 6.28 6.84 5.57 5.54 2.82 1.81
ATP 1.21 1.37 1.42 1.46 6.51 6.30 2.62
KLA/ATP 6.74 8.26 8.17 7.73 8.90 5.34 4.14
Notch1
KLA  ATP  ATP+KLA
 Z11886 gb|M.musculus notch-1 mRNA. [Z11886] KLA 8.43 7.03 7.93 7.02 5.78 3.21 1.90
ATP 1.08 1.18 1.52 1.48 7.39 7.40 2.89
KLA/ATP 7.94 8.61 10.64 8.15 11.74 7.12 4.49
Notch2
KLA  ATP  ATP+KLA
 NM_010928 Notch gene homolog 2 (Drosophila) (Notch2), mRNA [NM_010928] KLA 6.46 5.78 6.73 5.12 3.74 1.77 1.43
ATP 1.14 1.03 1.41 1.60 4.21 4.00 1.53
KLA/ATP 6.27 7.06 8.81 6.35 3.59 2.69 2.38
Notch3
KLA  ATP  ATP+KLA
 NM_008716 Notch gene homolog 3 (Drosophila) (Notch3), mRNA [NM_008716] KLA .98 1.03 1.03 1.00 1.01 .84 .92
ATP .91 1.02 1.05 1.01 .99 .99 1.05
KLA/ATP .94 .98 1.09 1.05 1.01 .97 .98
Notch4
KLA  ATP  ATP+KLA
 NM_010929 Notch gene homolog 4 (Drosophila) (Notch4), mRNA [NM_010929] KLA .72 .74 .52 .54 .51 .71 1.01
ATP .98 1.05 1.03 .96 .72 .67 1.14
KLA/ATP .70 .69 .55 .56 .56 .72 1.24
Numb
KLA  ATP  ATP+KLA
 NM_010949 numb gene homolog (Drosophila) (Numb), mRNA [NM_010949] KLA .73 .74 .75 .76 .66 .87 1.05
ATP .80 .87 .86 1.15 .96 .78 1.29
KLA/ATP .68 .68 .67 .81 .69 .85 1.59
Numbl
KLA  ATP  ATP+KLA
 U96441 Numblike (m-nbl) mRNA, complete cds. [U96441] KLA .99 .92 .81 .82 .94 .90 .88
ATP 1.01 1.04 1.02 .89 .91 1.35 .98
KLA/ATP .90 .87 .97 .93 .91 1.29 .96
Pcaf
KLA  ATP  ATP+KLA
 NM_020005 p300/CBP-associated factor (Pcaf), mRNA [NM_020005] KLA 2.47 2.38 3.01 3.89 3.93 2.64 1.24
ATP 1.14 1.21 1.23 .99 .93 1.29 .91
KLA/ATP 2.58 2.82 3.67 2.48 2.42 2.28 2.26
Psen1
KLA  ATP  ATP+KLA
 NM_008943 presenilin 1 (Psen1), mRNA [NM_008943] KLA 1.22 1.31 1.54 1.90 2.50 2.67 2.01
ATP 1.04 1.10 .89 1.00 1.21 2.18 1.73
KLA/ATP 1.33 1.37 1.22 1.52 1.69 2.61 2.95
Psen2
KLA  ATP  ATP+KLA
 NM_011183 presenilin 2 (Psen2), mRNA [NM_011183] KLA .70 .68 .68 .77 .80 1.20 2.41
ATP 1.02 1.04 1.21 1.08 .93 .71 1.04
KLA/ATP .70 .71 .84 .74 .99 1.11 1.56
Psenen
KLA  ATP  ATP+KLA
 NM_025498 presenilin enhancer 2 homolog (C. elegans) (Psenen), mRNA [NM_025498] KLA .91 .96 .94 .98 1.05 1.19 1.31
ATP .96 1.10 1.15 1.58 1.59 1.28 1.26
KLA/ATP 1.03 1.09 .99 1.58 1.52 1.51 1.70
Ptcra
KLA  ATP  ATP+KLA
 NM_011195 pre T-cell antigen receptor alpha (Ptcra), mRNA [NM_011195] KLA .99 .92 .98 .97 .94 1.01 .92
ATP .98 1.00 1.01 .97 1.01 .97 1.00
KLA/ATP .99 1.04 1.06 .93 1.00 .91 1.06
Rbpj
KLA  ATP  ATP+KLA
 NM_009035 recombination signal binding protein for immunoglobulin kappa J region (Rbpj), transcript variant 1, mRNA [NM_009035] KLA .92 .88 1.03 1.33 1.65 1.48 .97
ATP 1.07 1.10 1.09 1.18 1.35 1.61 1.23
KLA/ATP .86 .86 .82 1.03 .70 .77 1.46
Rbpjl
KLA  ATP  ATP+KLA
 NM_009036 recombination signal binding protein for immunoglobulin kappa J region-like (Rbpjl), mRNA [NM_009036] KLA .94 .98 .94 .99 1.07 1.02 1.02
ATP .97 .96 1.10 1.27 1.05 1.10 .98
KLA/ATP 1.00 1.02 1.00 .95 .96 .94 1.01
Rfng
KLA  ATP  ATP+KLA
 NM_009053 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Rfng), mRNA [NM_009053] KLA .91 .88 .85 .86 .87 .94 .91
ATP 1.03 1.15 .93 1.46 1.02 .76 1.09
KLA/ATP .99 .89 .73 1.17 .80 .77 .93
Snw1
KLA  ATP  ATP+KLA
 NM_025507 SNW domain containing 1 (Snw1), mRNA [NM_025507] KLA 2.06 2.04 2.00 2.32 1.97 1.86 1.63
ATP 1.12 1.08 1.10 1.02 1.17 1.61 1.60
KLA/ATP 1.90 2.12 2.63 2.35 2.27 2.75 2.79