Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Taste transduction (mmu04742)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
Accn1	KLA  ATP  ATP+KLA	BC038551	amiloride-sensitive cation channel 1, neuronal (degenerin), mRNA (cDNA clone IMAGE:5119213), complete cds. [BC038551]	KLA	1.04	1.07	1.02	1.00	.98	1.02	.98
				ATP	1.08	.97	.97	.97	1.01	1.07	1.02
				KLA/ATP	1.05	.95	1.00	1.07	.97	.99	1.02
Accn1	KLA  ATP  ATP+KLA	NM_007384	amiloride-sensitive cation channel 1, neuronal (degenerin) (Accn1), transcript variant 1, mRNA [NM_007384]	KLA	1.00	.99	1.05	.98	1.00	1.07	1.07
				ATP	1.00	.98	1.02	1.02	1.01	.99	.97
				KLA/ATP	1.01	.99	1.04	1.02	1.00	.94	.96
Adcy4	KLA  ATP  ATP+KLA	NM_080435	adenylate cyclase 4 (Adcy4), mRNA [NM_080435]	KLA	1.05	1.07	.96	1.00	1.04	1.05	1.05
				ATP	1.02	1.05	1.02	1.48	1.37	1.08	1.09
				KLA/ATP	1.00	1.05	.91	1.19	1.35	1.27	1.08
Adcy6	KLA  ATP  ATP+KLA	NM_007405	adenylate cyclase 6 (Adcy6), mRNA [NM_007405]	KLA	1.10	1.16	1.16	1.09	1.08	1.06	.99
				ATP	1.05	.97	1.08	1.12	1.08	1.08	1.04
				KLA/ATP	1.14	1.20	1.29	1.30	1.25	1.11	1.07
Adcy8	KLA  ATP  ATP+KLA	NM_009623	adenylate cyclase 8 (Adcy8), mRNA [NM_009623]	KLA	1.00	1.00	1.07	.97	1.04	.98	1.02
				ATP	1.04	1.05	1.14	1.03	.99	1.00	.97
				KLA/ATP	1.05	1.04	1.00	1.03	.98	.94	.96
Cacna1a	KLA  ATP  ATP+KLA	NM_007578	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Cacna1a), mRNA [NM_007578]	KLA	.71	.66	.61	.63	.60	.71	.72
				ATP	1.07	1.04	.89	1.08	.71	.56	.75
				KLA/ATP	.71	.72	.85	.69	.64	.63	.68
Cacna1b	KLA  ATP  ATP+KLA	U04999	N-type calcium channel alpha1 subunit mRNA, complete cds [U04999]	KLA	.94	.94	.95	.88	1.09	.85	.92
				ATP	1.06	1.17	1.00	1.24	1.59	1.15	1.17
				KLA/ATP	.91	.91	.95	.95	.90	.97	1.01
Gnas	KLA  ATP  ATP+KLA	AF107847	neuroendocrine-specific Golgi protein p55 isoform 1 (XLalphas) alternatively spliced mRNA, complete cds. [AF107847]	KLA	1.04	.94	1.00	1.05	1.04	.98	1.00
				ATP	.98	.97	.96	1.00	.99	.98	1.02
				KLA/ATP	1.04	1.02	.96	.95	1.01	.96	1.01
Gnas	KLA  ATP  ATP+KLA	AK017423	10 days neonate head cDNA, RIKEN full-length enriched library, clone:5530400H20 product:novel noncoding RNA overlapping the exon 1A, 1 and 2 of Gnas, full insert sequence. [AK017423]	KLA	.85	1.08	.97	.92	1.05	1.03	1.08
				ATP	.99	1.30	2.11	1.73	1.23	1.01	1.02
				KLA/ATP	.96	1.06	1.58	1.34	1.29	1.05	.91
Gnas	KLA  ATP  ATP+KLA	NM_001077510	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), transcript variant 8, mRNA [NM_001077510]	KLA	.99	1.03	.97	.91	1.03	.95	.97
				ATP	1.04	1.19	1.15	1.61	1.24	.91	1.00
				KLA/ATP	1.06	.97	1.01	1.46	1.04	.85	1.01
Gnas	KLA  ATP  ATP+KLA	S49980	gb|stimulatory G protein alpha subunit {clone WC-16} [mice, whole cochlea, mRNA Partial, 356 nt]. [S49980]	KLA	.91	.88	1.03	.87	.90	.84	1.01
				ATP	1.16	1.22	1.02	1.55	1.16	.80	.99
				KLA/ATP	1.01	1.13	.86	1.12	.97	.85	1.08
Gnb1	KLA  ATP  ATP+KLA	NM_008142	guanine nucleotide binding protein (G protein), beta 1 (Gnb1), mRNA [NM_008142]	KLA	1.11	1.18	1.22	1.19	1.29	1.32	1.76
				ATP	1.02	1.09	.84	.99	.97	.89	1.22
				KLA/ATP	1.20	1.25	.85	1.01	.86	.91	1.57
Gnb3	KLA  ATP  ATP+KLA	NM_013530	guanine nucleotide binding protein (G protein), beta 3 (Gnb3), mRNA [NM_013530]	KLA	.99	1.00	.98	1.03	.94	.99	.96
				ATP	1.01	1.02	.97	.95	1.01	.97	.92
				KLA/ATP	.99	1.02	1.02	.98	.99	.85	.99
Gng13	KLA  ATP  ATP+KLA	NM_022422	guanine nucleotide binding protein (G protein), gamma 13 (Gng13), mRNA [NM_022422]	KLA	1.04	1.04	.94	1.00	1.00	1.05	.96
				ATP	1.07	1.05	1.02	.94	.98	1.03	1.01
				KLA/ATP	1.01	.99	1.05	1.01	1.01	.98	1.02
Gng3	KLA  ATP  ATP+KLA	NM_010316	guanine nucleotide binding protein (G protein), gamma 3 (Gng3), mRNA [NM_010316]	KLA	1.00	.98	1.02	.95	.99	1.00	1.06
				ATP	.98	1.05	.99	1.03	1.05	1.03	.97
				KLA/ATP	1.01	1.00	1.07	1.01	1.04	1.04	1.05
Grm4	KLA  ATP  ATP+KLA	NM_001013385	glutamate receptor, metabotropic 4 (Grm4), mRNA [NM_001013385]	KLA	.94	.97	.98	1.01	1.01	1.02	1.08
				ATP	.99	.94	1.03	.98	.95	.98	1.07
				KLA/ATP	.99	1.02	.93	1.00	1.02	1.03	1.05
Itpr3	KLA  ATP  ATP+KLA	NM_080553	inositol 1,4,5-triphosphate receptor 3 (Itpr3), mRNA [NM_080553]	KLA	.55	.51	.45	.41	.34	.34	.45
				ATP	1.01	.92	1.02	.57	.46	.34	1.22
				KLA/ATP	.56	.48	.48	.29	.33	.27	.65
Kcnb1	KLA  ATP  ATP+KLA	NM_008420	potassium voltage gated channel, Shab-related subfamily, member 1 (Kcnb1), mRNA [NM_008420]	KLA	.98	.99	.96	1.01	1.02	1.02	1.04
				ATP	.97	1.01	.98	1.02	.99	1.00	1.02
				KLA/ATP	.96	.99	.97	1.00	1.01	.99	.98
Mm.28666 8	KLA  ATP  ATP+KLA	148271108	Unknown	KLA	1.06	1.03	1.02	1.00	.98	.97	.96
				ATP	1.04	1.07	.98	1.01	1.05	1.04	.97
				KLA/ATP	1.06	1.04	.98	1.08	1.01	1.02	.98
Mm.4424	KLA  ATP  ATP+KLA	110225367	Unknown	KLA	.99	.93	1.01	1.02	1.00	.92	1.00
				ATP	.98	1.03	3.11	1.13	1.19	1.03	1.11
				KLA/ATP	.95	.97	.97	.96	.93	1.01	.99
Pde1a	KLA  ATP  ATP+KLA	NM_001009978	phosphodiesterase 1A, calmodulin-dependent (Pde1a), transcript variant 7, mRNA [NM_001009978]	KLA	1.42	1.46	1.58	1.35	1.43	1.21	1.25
				ATP	1.02	1.01	1.07	1.13	1.50	1.46	1.08
				KLA/ATP	1.44	1.52	1.27	1.38	1.23	1.40	1.41
Pde1a	KLA  ATP  ATP+KLA	NM_016744	phosphodiesterase 1A, calmodulin-dependent (Pde1a), mRNA [NM_016744]	KLA	.98	.99	1.03	1.04	1.02	.96	1.04
				ATP	1.02	1.02	1.05	1.03	1.00	.98	.98
				KLA/ATP	.99	1.00	1.08	1.03	1.01	1.04	1.00
Plcb2	KLA  ATP  ATP+KLA	NM_177568	phospholipase C, beta 2 (Plcb2), mRNA [NM_177568]	KLA	.70	.68	.64	.67	.65	.76	.88
				ATP	.95	.94	1.04	.94	.72	.57	1.19
				KLA/ATP	.69	.68	.72	.63	.65	.55	.70
Prkaca	KLA  ATP  ATP+KLA	NM_008854	protein kinase, cAMP dependent, catalytic, alpha (Prkaca), mRNA [NM_008854]	KLA	.71	.74	.72	.70	.72	.84	.85
				ATP	1.05	.98	.89	.92	.76	.60	1.02
				KLA/ATP	.79	.74	.55	.65	.60	.65	.93
Prkacb	KLA  ATP  ATP+KLA	NM_011100	protein kinase, cAMP dependent, catalytic, beta (Prkacb), mRNA [NM_011100]	KLA	.69	.70	.66	.58	.51	.55	.59
				ATP	1.02	1.19	.97	1.01	.69	.38	.56
				KLA/ATP	.72	.73	.57	.62	.47	.41	.45
Prkx	KLA  ATP  ATP+KLA	NM_016979	protein kinase, X-linked (Prkx), mRNA [NM_016979]	KLA	3.61	3.79	4.67	4.66	4.85	4.19	1.43
				ATP	.98	.90	.63	.61	1.12	1.90	1.29
				KLA/ATP	3.56	3.36	2.62	2.06	2.26	2.87	2.31
Scnn1a	KLA  ATP  ATP+KLA	NM_011324	sodium channel, nonvoltage-gated, type I, alpha (Scnn1a), mRNA [NM_011324]	KLA	.86	.87	.83	.83	.84	.95	1.22
				ATP	1.03	.97	.91	.90	.81	.73	.87
				KLA/ATP	.88	.85	.87	.76	.77	.76	.81
Scnn1b	KLA  ATP  ATP+KLA	NM_011325	sodium channel, nonvoltage-gated 1 beta (Scnn1b), mRNA [NM_011325]	KLA	1.00	.99	1.05	1.04	.98	1.01	1.11
				ATP	1.00	.99	.93	1.03	1.04	.96	.96
				KLA/ATP	.98	1.03	.94	.97	.97	1.01	.86
Scnn1g	KLA  ATP  ATP+KLA	NM_011326	sodium channel, nonvoltage-gated 1 gamma (Scnn1g), mRNA [NM_011326]	KLA	.97	.98	1.05	1.04	1.00	1.00	.96
				ATP	1.04	.99	.99	1.01	.98	1.04	.95
				KLA/ATP	.94	.96	.99	.94	.99	1.00	1.02
Tas1r1	KLA  ATP  ATP+KLA	NM_031867	taste receptor, type 1, member 1 (Tas1r1), mRNA [NM_031867]	KLA	.99	1.06	1.03	1.14	1.01	1.00	1.06
				ATP	1.00	.98	1.03	.98	.99	1.03	.89
				KLA/ATP	.98	1.02	1.09	.97	1.01	1.00	1.09
Tas1r2	KLA  ATP  ATP+KLA	NM_031873	taste receptor, type 1, member 2 (Tas1r2), mRNA [NM_031873]	KLA	.98	.97	1.09	1.07	1.04	1.07	1.11
				ATP	.96	1.00	1.06	2.63	2.51	1.41	1.19
				KLA/ATP	1.02	1.08	1.11	2.55	2.91	1.76	1.13
Tas1r3	KLA  ATP  ATP+KLA	NM_031872	taste receptor, type 1, member 3 (Tas1r3), mRNA [NM_031872]	KLA	1.11	1.20	1.23	1.21	1.17	1.44	1.13
				ATP	1.05	1.07	1.09	1.20	1.07	1.05	1.14
				KLA/ATP	1.18	1.18	1.03	1.19	1.18	1.10	1.25
Tas2r102	KLA  ATP  ATP+KLA	NM_199153	taste receptor, type 2, member 102 (Tas2r102), mRNA [NM_199153]	KLA	.95	.99	1.06	1.04	.99	.97	1.03
				ATP	.94	1.02	1.01	1.00	1.05	1.03	.98
				KLA/ATP	.99	1.00	.97	.89	1.04	1.01	.90
Tas2r105	KLA  ATP  ATP+KLA	NM_020501	taste receptor, type 2, member 105 (Tas2r105), mRNA [NM_020501]	KLA	.97	.99	.99	1.04	.92	1.00	.94
				ATP	1.04	.99	.97	.99	.99	.98	1.04
				KLA/ATP	.98	1.02	1.01	1.00	.92	.97	.98
Tas2r107	KLA  ATP  ATP+KLA	NM_199154	taste receptor, type 2, member 107 (Tas2r107), mRNA [NM_199154]	KLA	.96	1.06	1.00	1.03	.89	.97	.96
				ATP	1.05	1.04	.93	.94	.93	.97	1.01
				KLA/ATP	1.00	.96	.98	.96	.99	.93	.98
Tas2r108	KLA  ATP  ATP+KLA	NM_020502	taste receptor, type 2, member 108 (Tas2r108), mRNA [NM_020502]	KLA	.95	.99	.93	.95	.96	1.05	.99
				ATP	1.01	1.01	1.07	1.05	1.01	.91	1.06
				KLA/ATP	1.03	.99	1.01	.97	1.00	1.07	1.02
Tas2r110	KLA  ATP  ATP+KLA	NM_199155	taste receptor, type 2, member 110 (Tas2r110), mRNA [NM_199155]	KLA	.96	1.01	1.02	.98	1.01	1.00	.96
				ATP	1.00	1.00	.99	.92	1.01	1.03	1.02
				KLA/ATP	.97	1.04	1.03	.98	.96	1.00	.97
Tas2r116	KLA  ATP  ATP+KLA	NM_053212	taste receptor, type 2, member 116 (Tas2r116), mRNA [NM_053212]	KLA	.96	.97	1.01	.96	1.03	.91	1.05
				ATP	.99	.97	.94	1.05	.98	1.03	.98
				KLA/ATP	.97	1.01	.86	.95	.99	1.05	.95
Tas2r118	KLA  ATP  ATP+KLA	NM_207022	taste receptor, type 2, member 118 (Tas2r118), mRNA [NM_207022]	KLA	1.03	1.02	1.00	.96	.99	1.04	.96
				ATP	.98	1.06	1.17	1.03	.96	1.02	1.01
				KLA/ATP	1.00	.93	1.08	1.02	.92	.93	.97
Tas2r119	KLA  ATP  ATP+KLA	NM_020503	taste receptor, type 2, member 119 (Tas2r119), mRNA [NM_020503]	KLA	1.02	1.01	1.00	1.04	.98	.99	1.15
				ATP	1.02	1.01	.98	1.03	1.02	1.00	.96
				KLA/ATP	.99	1.01	1.00	.99	.99	.99	1.03
Tas2r130	KLA  ATP  ATP+KLA	NM_199156	taste receptor, type 2, member 130 (Tas2r130), mRNA [NM_199156]	KLA	1.01	.97	.99	1.00	1.04	1.04	1.00
				ATP	1.00	.96	1.01	1.03	1.00	.98	.96
				KLA/ATP	.93	.93	1.00	1.08	1.08	1.05	1.07
Tas2r135	KLA  ATP  ATP+KLA	NM_199159	taste receptor, type 2, member 135 (Tas2r135), mRNA [NM_199159]	KLA	1.04	1.03	.99	.99	.94	1.03	.97
				ATP	1.00	.98	1.07	1.06	1.00	1.05	1.03
				KLA/ATP	1.02	.94	.99	1.09	1.01	1.00	1.05
Tas2r136	KLA  ATP  ATP+KLA	NM_181276	taste receptor, type 2, member 136 (Tas2r136), mRNA [NM_181276]	KLA	.99	.96	1.02	1.06	1.00	1.00	1.04
				ATP	.99	1.00	.94	1.03	1.01	1.02	1.04
				KLA/ATP	.98	1.02	1.02	.99	1.01	.97	1.07
Tas2r139	KLA  ATP  ATP+KLA	NM_181275	taste receptor, type 2, member 139 (Tas2r139), mRNA [NM_181275]	KLA	1.09	.94	1.02	.98	1.07	1.07	.97
				ATP	.98	.95	1.00	1.01	1.12	.98	1.03
				KLA/ATP	.90	.97	1.03	1.00	1.02	1.00	1.03
Tas2r140	KLA  ATP  ATP+KLA	NM_021562	taste receptor, type 2, member 140 (Tas2r140), mRNA [NM_021562]	KLA	.98	1.03	.99	.95	.98	.99	.96
				ATP	1.02	1.01	.95	.90	.93	.92	.98
				KLA/ATP	.95	1.02	1.02	.95	.94	.89	1.01
Trpm5	KLA  ATP  ATP+KLA	NM_020277	transient receptor potential cation channel, subfamily M, member 5 (Trpm5), mRNA [NM_020277]	KLA	1.02	1.01	.98	1.02	.99	.96	1.03
				ATP	.98	.94	.93	.93	1.06	.90	.98
				KLA/ATP	1.06	1.04	1.02	.99	1.03	1.04	1.05