Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Graft-versus-host disease (mmu05332)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
14927508
3
KLA  ATP  ATP+KLA
 149275083 Unknown KLA .74 .68 .68 .77 .71 .85 .69
ATP .85 .69 1.26 .89 .89 1.26 .64
KLA/ATP .64 .63 1.07 .96 1.39 1.07 .82
Cd28
KLA  ATP  ATP+KLA
 NM_007642 CD28 antigen (Cd28), mRNA [NM_007642] KLA .52 .51 .45 .50 .36 .33 .18
ATP 1.11 1.26 1.08 1.25 1.99 1.42 2.08
KLA/ATP .51 .51 .58 .60 .56 .53 .38
Cd80
KLA  ATP  ATP+KLA
 NM_009855 CD80 antigen (Cd80), mRNA [NM_009855] KLA 2.13 1.91 1.89 1.78 1.29 1.00 .82
ATP .99 1.20 1.98 1.49 1.37 2.40 1.71
KLA/ATP 2.05 2.32 3.09 2.27 1.95 2.89 3.07
Cd86
KLA  ATP  ATP+KLA
 NM_019388 CD86 antigen (Cd86), mRNA [NM_019388] KLA 13.80 14.41 18.21 18.33 17.37 17.26 4.82
ATP 1.02 1.00 2.20 3.64 5.16 6.79 3.81
KLA/ATP 14.80 14.66 18.10 18.96 19.38 20.42 14.21
Fas
KLA  ATP  ATP+KLA
 AK086933 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030012O08 product:tumor necrosis factor receptor superfamily, member 6, full insert sequence. [AK086933] KLA 6.31 6.56 6.33 6.70 4.93 3.74 2.48
ATP .95 1.04 1.33 1.55 1.85 6.00 2.77
KLA/ATP 5.67 7.16 7.71 7.73 6.02 5.79 7.85
Fas
KLA  ATP  ATP+KLA
 NM_007987 Fas (TNF receptor superfamily member 6) (Fas), mRNA [NM_007987] KLA 17.08 17.45 19.08 17.38 13.33 6.78 4.46
ATP .98 .96 1.64 3.05 5.58 12.91 1.89
KLA/ATP 16.57 17.25 26.06 23.57 22.03 16.74 13.29
Fasl
KLA  ATP  ATP+KLA
 NM_010177 Fas ligand (TNF superfamily, member 6) (Fasl), mRNA [NM_010177] KLA 1.03 1.01 1.03 1.02 1.01 1.01 1.00
ATP 1.00 .99 1.04 1.21 1.18 1.20 1.01
KLA/ATP 1.00 1.02 1.07 1.16 1.18 1.23 1.00
Gzmb
KLA  ATP  ATP+KLA
 NM_013542 granzyme B (Gzmb), mRNA [NM_013542] KLA 1.03 .96 1.07 1.10 1.04 .98 1.07
ATP .90 1.05 1.02 .98 .90 1.09 1.02
KLA/ATP .96 .98 1.20 1.17 1.03 1.06 1.07
H2-Aa
KLA  ATP  ATP+KLA
 NM_010378 histocompatibility 2, class II antigen A, alpha (H2-Aa), mRNA [NM_010378] KLA 1.43 1.59 1.68 1.50 1.62 1.89 1.64
ATP 1.07 1.15 1.27 1.90 1.92 1.77 1.55
KLA/ATP 1.62 1.81 1.74 2.29 1.89 1.92 2.19
H2-Ab1
KLA  ATP  ATP+KLA
 BC010322 histocompatibility 2, class II antigen A, beta 1, mRNA (cDNA clone MGC:6297 IMAGE:2651058), complete cds [BC010322] KLA 1.73 1.76 1.77 1.55 1.95 2.10 2.27
ATP 1.03 1.18 1.32 1.99 1.79 1.56 1.61
KLA/ATP 1.70 2.01 1.74 2.52 1.58 2.01 2.75
H2-Ab1
KLA  ATP  ATP+KLA
 NM_207105 histocompatibility 2, class II antigen A, beta 1 (H2-Ab1), mRNA [NM_207105] KLA 2.02 2.15 2.07 2.09 2.32 2.78 3.08
ATP 1.11 1.20 1.42 2.33 2.33 2.25 1.87
KLA/ATP 2.11 2.32 2.52 3.62 2.67 2.96 5.04
H2-Bl
KLA  ATP  ATP+KLA
 NM_008199 histocompatibility 2, blastocyst (H2-Bl), mRNA [NM_008199] KLA 1.29 1.32 1.40 1.28 1.36 1.46 1.80
ATP 1.04 1.11 1.02 1.34 1.28 1.32 1.47
KLA/ATP 1.32 1.39 1.34 1.77 1.41 1.61 2.39
H2-D1
KLA  ATP  ATP+KLA
 AK169750 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430019E13 product:histocompatibility 2, D region locus 1, full insert sequence [AK169750] KLA .99 .98 .96 .99 .93 .91 .94
ATP .96 1.01 1.02 .95 1.05 1.00 .98
KLA/ATP .92 .94 .97 .97 .98 .92 1.03
H2-D1
KLA  ATP  ATP+KLA
 NM_010380 histocompatibility 2, D region locus 1 (H2-D1), mRNA [NM_010380] KLA 1.38 1.45 1.73 1.42 1.70 1.76 2.56
ATP 1.15 1.11 .86 1.12 1.19 1.28 1.90
KLA/ATP 1.58 1.72 1.38 1.56 1.38 1.69 3.21
H2-DMa
KLA  ATP  ATP+KLA
 NM_010386 histocompatibility 2, class II, locus DMa (H2-DMa), mRNA [NM_010386] KLA 1.49 1.50 1.65 1.65 1.91 2.23 1.69
ATP 1.04 1.12 1.26 1.67 1.24 .99 1.32
KLA/ATP 1.58 1.68 1.70 2.02 1.37 1.35 1.90
H2-DMb1
KLA  ATP  ATP+KLA
 NM_010387 histocompatibility 2, class II, locus Mb1 (H2-DMb1), mRNA [NM_010387] KLA 1.06 1.14 1.08 1.13 1.24 1.41 1.37
ATP 1.01 1.02 1.09 1.14 .92 .73 1.36
KLA/ATP 1.13 1.05 1.21 1.17 .98 .83 1.41
H2-DMb2
KLA  ATP  ATP+KLA
 NM_010388 histocompatibility 2, class II, locus Mb2 (H2-DMb2), mRNA [NM_010388] KLA 1.00 1.04 .93 .95 .96 .95 1.03
ATP 1.06 1.04 .94 .92 .97 .95 1.00
KLA/ATP .90 .94 .99 .94 .90 .96 .92
H2-Eb1
KLA  ATP  ATP+KLA
 X52641 gb|Mouse mRNA for I-A beta NOD. [X52641] KLA 1.94 2.06 1.94 1.87 1.96 2.18 1.76
ATP 1.11 1.20 1.53 2.70 3.02 2.91 1.40
KLA/ATP 2.09 2.11 2.26 3.55 2.76 3.05 3.05
H2-K1
KLA  ATP  ATP+KLA
 M69070 mRNA, complete cds. [M69070] KLA 1.76 1.66 1.78 1.78 1.87 2.23 2.99
ATP .98 .97 1.19 1.45 1.36 1.68 2.17
KLA/ATP 1.68 1.70 1.87 1.96 1.87 2.13 3.82
H2-K1
KLA  ATP  ATP+KLA
 NM_001001892 histocompatibility 2, K1, K region (H2-K1), transcript variant 1, mRNA [NM_001001892] KLA 1.82 1.66 1.73 1.76 1.87 2.29 3.17
ATP .98 .97 1.13 1.32 1.29 1.57 2.09
KLA/ATP 1.64 1.71 1.77 1.82 1.71 2.12 3.91
H2-M1
KLA  ATP  ATP+KLA
 NM_177636 histocompatibility 2, M region locus 1 (H2-M1), mRNA [NM_177636] KLA .99 1.01 1.02 1.02 .97 1.03 1.04
ATP 1.01 .99 1.03 1.07 .92 1.03 .98
KLA/ATP 1.08 .97 .94 1.04 1.00 1.04 1.02
H2-M10.1
KLA  ATP  ATP+KLA
 NM_013544 histocompatibility 2, M region locus 10.1 (H2-M10.1), mRNA [NM_013544] KLA 1.04 1.00 1.05 .95 .98 1.04 .94
ATP 1.06 1.04 .96 .95 .97 .98 .98
KLA/ATP 1.02 1.07 .98 1.02 .92 .92 .99
H2-M10.2
KLA  ATP  ATP+KLA
 NM_177923 histocompatibility 2, M region locus 10.2 (H2-M10.2), mRNA [NM_177923] KLA 2.18 2.23 2.51 2.61 2.90 3.30 3.40
ATP 1.08 1.02 1.22 1.39 1.30 1.56 2.66
KLA/ATP 2.23 2.53 2.82 2.91 2.89 2.60 3.92
H2-M10.3
KLA  ATP  ATP+KLA
 AY211080 major histocompatibility complex class Ib M10.3 mRNA, complete cds [AY211080] KLA .95 1.08 .99 .95 1.00 1.11 1.04
ATP .98 .96 1.00 .99 1.00 .99 1.00
KLA/ATP 1.00 .99 1.00 1.00 .99 .96 1.03
H2-M10.4
KLA  ATP  ATP+KLA
 NM_177634 histocompatibility 2, M region locus 10.4 (H2-M10.4), mRNA [NM_177634] KLA 1.03 1.04 1.08 1.08 1.04 1.03 1.03
ATP 1.07 1.05 .97 1.08 .95 .97 1.02
KLA/ATP 1.02 .97 1.02 .99 .93 1.06 1.04
H2-M10.5
KLA  ATP  ATP+KLA
 NM_177637 histocompatibility 2, M region locus 10.5 (H2-M10.5), mRNA [NM_177637] KLA 1.00 1.04 1.13 .93 .99 1.00 1.07
ATP 1.02 1.02 1.04 .90 1.03 .99 .99
KLA/ATP 1.06 1.03 .97 1.03 1.03 .98 1.04
H2-M10.6
KLA  ATP  ATP+KLA
 NM_201611 histocompatibility 2, M region locus 10.6 (H2-M10.6), mRNA [NM_201611] KLA 1.06 .99 1.04 1.06 .98 1.03 .92
ATP 1.04 1.09 .96 .98 .94 1.07 .98
KLA/ATP 1.01 1.06 1.02 .96 .96 1.04 1.05
H2-M11
KLA  ATP  ATP+KLA
 NM_177635 histocompatibility 2, M region locus 11 (H2-M11), mRNA [NM_177635] KLA 1.03 1.07 1.06 1.02 .96 1.05 1.03
ATP 1.02 .96 1.08 .98 1.04 .94 .98
KLA/ATP 1.03 1.03 .99 1.01 1.01 .98 .99
H2-M3
KLA  ATP  ATP+KLA
 NM_013819 histocompatibility 2, M region locus 3 (H2-M3), mRNA [NM_013819] KLA 1.90 2.04 2.09 2.37 2.30 2.56 2.73
ATP 1.00 1.00 1.19 1.34 1.00 .70 1.09
KLA/ATP 1.77 1.94 2.37 2.49 1.89 1.67 2.06
H2-M9
KLA  ATP  ATP+KLA
 NM_008205 histocompatibility 2, M region locus 9 (H2-M9), mRNA [NM_008205] KLA 1.03 .99 .96 .98 1.01 .99 1.03
ATP .96 1.06 .94 .96 1.05 1.06 1.00
KLA/ATP .96 1.01 1.01 .99 .97 .95 .98
H2-Oa
KLA  ATP  ATP+KLA
 NM_008206 histocompatibility 2, O region alpha locus (H2-Oa), mRNA [NM_008206] KLA 1.22 1.32 1.37 1.33 1.31 1.26 1.53
ATP 1.02 1.05 1.16 1.21 1.12 1.07 1.16
KLA/ATP 1.32 1.34 1.31 1.34 1.25 1.35 2.78
H2-Ob
KLA  ATP  ATP+KLA
 NM_010389 histocompatibility 2, O region beta locus (H2-Ob), mRNA [NM_010389] KLA 1.05 1.07 1.01 .96 1.10 1.02 1.00
ATP 1.04 .99 1.00 1.03 .94 1.07 .94
KLA/ATP 1.02 .97 1.06 1.08 1.00 .96 1.05
H2-Q1
KLA  ATP  ATP+KLA
 NM_010390 histocompatibility 2, Q region locus 1 (H2-Q1), mRNA [NM_010390] KLA 1.05 1.08 1.03 1.02 .98 1.09 1.00
ATP .99 .92 .93 1.01 1.01 1.04 1.00
KLA/ATP 1.07 1.00 1.00 .91 .97 1.07 1.04
H2-Q10
KLA  ATP  ATP+KLA
 NM_010391 histocompatibility 2, Q region locus 10 (H2-Q10), mRNA [NM_010391] KLA 1.50 1.50 1.70 1.64 1.67 1.79 2.18
ATP 1.12 1.11 1.09 1.46 1.42 1.43 1.69
KLA/ATP 1.61 1.72 1.79 1.94 1.81 1.81 2.93
H2-Q2
KLA  ATP  ATP+KLA
 NM_010392 histocompatibility 2, Q region locus 2 (H2-Q2), mRNA [NM_010392] KLA 1.55 1.52 1.61 1.45 1.83 1.94 2.47
ATP 1.09 1.13 .92 1.16 1.17 1.30 1.88
KLA/ATP 1.55 1.70 1.58 1.80 1.64 1.87 3.43
H2-Q7
KLA  ATP  ATP+KLA
 NM_010394 histocompatibility 2, Q region locus 7 (H2-Q7), mRNA [NM_010394] KLA 1.57 1.58 1.74 1.55 1.82 2.00 2.76
ATP 1.05 1.09 .84 1.12 1.12 1.23 2.00
KLA/ATP 1.63 1.75 1.43 1.67 1.53 1.80 3.48
H2-Q8
KLA  ATP  ATP+KLA
 NM_023124 histocompatibility 2, Q region locus 8 (H2-Q8), mRNA [NM_023124] KLA 7.48 6.46 6.41 7.15 7.46 9.60 18.27
ATP 1.01 .98 1.48 2.05 1.93 3.83 8.26
KLA/ATP 6.72 7.10 9.11 10.95 10.71 12.88 31.43
H2-T22
KLA  ATP  ATP+KLA
 NM_010397 histocompatibility 2, T region locus 22 (H2-T22), mRNA [NM_010397] KLA 5.21 5.40 5.81 6.31 7.42 9.49 7.50
ATP 1.01 .95 .88 .92 .93 3.65 5.53
KLA/ATP 4.83 5.12 4.58 4.74 4.81 6.89 14.89
H2-T23
KLA  ATP  ATP+KLA
 NM_010398 histocompatibility 2, T region locus 23 (H2-T23), mRNA [NM_010398] KLA 1.83 1.80 1.92 1.86 2.32 2.56 3.43
ATP 1.03 1.08 .85 1.18 1.09 1.30 2.49
KLA/ATP 1.76 1.92 1.62 1.93 1.76 2.13 4.06
H2-T24
KLA  ATP  ATP+KLA
 NM_008207 histocompatibility 2, T region locus 24 (H2-T24), mRNA [NM_008207] KLA 3.02 3.26 4.14 4.26 5.15 6.06 5.89
ATP 1.08 1.09 1.32 1.35 1.17 1.71 6.71
KLA/ATP 3.23 3.31 3.54 3.85 3.07 3.73 9.10
H2-T3
KLA  ATP  ATP+KLA
 NM_008208 histocompatibility 2, T region locus 3 (H2-T3), mRNA [NM_008208] KLA .95 1.04 1.00 .97 .97 .99 1.00
ATP .98 1.08 1.03 1.01 .98 1.02 1.03
KLA/ATP 1.05 .96 1.02 1.04 1.05 1.00 .97
Ifng
KLA  ATP  ATP+KLA
 NM_008337 interferon gamma (Ifng), mRNA [NM_008337] KLA 1.05 1.02 1.01 1.01 1.01 1.04 1.00
ATP 1.00 1.01 1.01 .98 .97 1.04 1.03
KLA/ATP 1.01 1.01 1.06 1.10 1.24 1.10 1.04
Il1a
KLA  ATP  ATP+KLA
 NM_010554 interleukin 1 alpha (Il1a), mRNA [NM_010554] KLA 32.45 35.22 31.30 20.95 28.57 18.36 19.02
ATP 1.04 1.02 2.21 5.46 11.06 32.07 3.40
KLA/ATP 32.02 41.20 35.12 46.91 28.76 42.72 57.80
Il1b
KLA  ATP  ATP+KLA
 NM_008361 interleukin 1 beta (Il1b), mRNA [NM_008361] KLA 149.78 133.59 100.91 116.58 86.48 89.37 64.72
ATP 3.49 13.96 61.44 70.91 82.12 162.79 28.18
KLA/ATP 130.32 139.00 219.12 148.17 165.44 172.57 146.98
Il2
KLA  ATP  ATP+KLA
 NM_008366 interleukin 2 (Il2), mRNA [NM_008366] KLA .96 .97 .96 1.00 .97 .97 .99
ATP 1.04 1.02 1.00 1.03 .97 .98 .97
KLA/ATP 1.01 .98 .97 1.00 .97 .97 .96
Il6
KLA  ATP  ATP+KLA
 NM_031168 interleukin 6 (Il6), mRNA [NM_031168] KLA 352.99 378.70 276.81 168.47 59.99 18.66 8.27
ATP 1.04 1.08 2.28 3.69 30.40 161.93 2.11
KLA/ATP 334.28 528.66 ###.## 935.86 302.45 355.36 99.65
Klra3
KLA  ATP  ATP+KLA
 NM_010648 killer cell lectin-like receptor, subfamily A, member 3 (Klra3), mRNA [NM_010648] KLA 1.02 1.00 .99 .98 .96 1.10 1.41
ATP 1.01 1.01 1.03 1.04 1.00 .94 1.13
KLA/ATP 1.02 1.00 .94 1.02 1.00 1.02 1.02
Klra7
KLA  ATP  ATP+KLA
 NM_014194 killer cell lectin-like receptor, subfamily A, member 7 (Klra7), transcript variant 2, mRNA [NM_014194] KLA 1.03 .96 .99 1.02 1.01 1.03 .99
ATP .99 .95 .95 1.00 1.09 1.05 1.09
KLA/ATP .94 .99 1.01 .99 1.02 1.06 1.08
Klra9
KLA  ATP  ATP+KLA
 NM_010651 killer cell lectin-like receptor subfamily A, member 9 (Klra9), mRNA [NM_010651] KLA .96 .90 1.01 1.04 .95 1.08 1.68
ATP 1.02 1.05 1.07 1.09 .96 1.04 1.30
KLA/ATP 1.01 .98 1.00 1.03 .94 .99 1.07
Klrc1
KLA  ATP  ATP+KLA
 NM_010652 killer cell lectin-like receptor subfamily C, member 1 (Klrc1), mRNA [NM_010652] KLA 1.00 .96 .99 .98 1.00 .98 1.01
ATP 1.03 .97 1.01 .93 1.10 1.03 1.04
KLA/ATP .98 .99 .93 1.08 1.13 .99 1.03
Klrd1
KLA  ATP  ATP+KLA
 NM_010654 killer cell lectin-like receptor, subfamily D, member 1 (Klrd1), mRNA [NM_010654] KLA .98 .99 .99 .94 .94 .93 1.03
ATP 1.13 1.28 1.48 1.94 1.59 1.04 1.00
KLA/ATP 1.00 .95 1.04 1.20 1.09 1.00 .94
LOC67670
8
KLA  ATP  ATP+KLA
 XM_992322 ref|PREDICTED: Mus musculus similar to class I (Qa) Q2k antigen (LOC676708), mRNA [XM_992322] KLA 2.18 2.22 2.32 2.27 2.28 2.77 3.62
ATP 1.04 1.17 1.17 2.19 1.83 1.75 2.30
KLA/ATP 2.20 2.44 2.25 3.41 2.30 2.63 5.00
Mm.19506
1
KLA  ATP  ATP+KLA
 76253707 Unknown KLA 5.35 4.83 5.36 6.20 6.87 9.80 7.83
ATP .97 .90 .96 .77 .80 3.98 5.87
KLA/ATP 4.63 4.51 4.51 3.75 4.39 7.21 16.38
Mm.25500
3
KLA  ATP  ATP+KLA
 161484596 Unknown KLA .35 .34 .35 .34 .22 .19 .10
ATP 1.09 1.27 1.13 1.29 2.25 1.66 2.22
KLA/ATP .38 .36 .39 .40 .49 .42 .32
Mm.43967
5
KLA  ATP  ATP+KLA
 133778954 Unknown KLA 1.76 1.74 1.70 1.72 1.75 2.14 3.19
ATP 1.00 1.01 1.18 1.28 1.25 1.48 1.84
KLA/ATP 1.67 1.64 1.70 1.79 1.63 2.04 3.36
Mm.43967
5
KLA  ATP  ATP+KLA
 149275074 Unknown KLA 2.17 2.23 2.26 2.58 2.26 2.10 1.43
ATP .96 .91 1.12 .90 .70 1.10 1.47
KLA/ATP 1.96 2.10 1.92 1.51 1.12 1.35 1.99
Mm.44165
1
KLA  ATP  ATP+KLA
 160333403 Unknown KLA 5.45 5.27 5.02 6.34 6.63 10.05 8.10
ATP .91 .84 .96 .75 .78 3.91 6.03
KLA/ATP 4.29 4.38 4.50 3.55 4.22 7.22 17.63
Prf1
KLA  ATP  ATP+KLA
 NM_011073 perforin 1 (pore forming protein) (Prf1), mRNA [NM_011073] KLA .99 1.02 1.05 1.08 1.00 1.03 .98
ATP 1.00 .97 1.03 .97 .97 .98 .91
KLA/ATP 1.07 .99 .93 .98 .98 .95 .99
Tnf
KLA  ATP  ATP+KLA
 NM_013693 tumor necrosis factor (Tnf), mRNA [NM_013693] KLA 13.35 12.76 10.71 9.03 10.64 7.39 8.32
ATP 2.01 2.48 8.27 19.20 9.72 4.09 1.49
KLA/ATP 12.72 15.76 12.73 17.34 5.10 3.61 6.07