Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Primary immunodeficiency (mmu05340)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Ada
KLA  ATP  ATP+KLA
 NM_007398 adenosine deaminase (Ada), mRNA [NM_007398] KLA .92 .93 .83 .92 .71 .59 .70
ATP .90 .91 1.24 1.79 1.48 .91 .43
KLA/ATP .82 .96 1.18 1.41 1.49 .78 .32
Aicda
KLA  ATP  ATP+KLA
 NM_009645 activation-induced cytidine deaminase (Aicda), mRNA [NM_009645] KLA 1.01 .99 .98 1.05 1.03 .99 1.17
ATP .95 1.02 .99 1.02 .94 1.34 1.09
KLA/ATP 1.05 .98 1.05 1.06 1.05 1.79 1.35
Aire
KLA  ATP  ATP+KLA
 NM_009646 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (Aire), mRNA [NM_009646] KLA 1.03 1.10 1.10 1.04 1.06 .97 .94
ATP 1.07 1.01 1.03 1.01 .95 .95 1.01
KLA/ATP .97 1.09 1.10 .94 .98 .93 .97
Blnk
KLA  ATP  ATP+KLA
 NM_008528 B-cell linker (Blnk), mRNA [NM_008528] KLA 1.53 1.39 1.23 1.31 1.01 1.41 1.21
ATP .95 .81 1.09 .87 2.09 1.28 .97
KLA/ATP 1.21 1.23 1.44 1.00 2.09 1.88 1.39
Btk
KLA  ATP  ATP+KLA
 NM_013482 Bruton agammaglobulinemia tyrosine kinase (Btk), mRNA [NM_013482] KLA 1.10 1.24 1.01 1.33 1.07 1.27 1.01
ATP .95 1.05 .86 .97 .66 .72 .82
KLA/ATP 1.14 1.35 1.12 1.52 .96 .70 .82
Cd19
KLA  ATP  ATP+KLA
 NM_009844 CD19 antigen (Cd19), mRNA [NM_009844] KLA 1.05 1.04 1.09 1.05 1.03 1.07 1.10
ATP 1.04 1.03 .99 1.07 .93 .97 .97
KLA/ATP 1.04 1.03 1.02 .97 1.01 1.00 1.08
Cd3d
KLA  ATP  ATP+KLA
 NM_013487 CD3 antigen, delta polypeptide (Cd3d), mRNA [NM_013487] KLA 1.01 1.05 1.00 .95 .98 1.03 1.02
ATP 1.02 .94 1.08 .99 .99 .94 1.05
KLA/ATP .93 .91 .99 .98 .96 .96 1.04
Cd3e
KLA  ATP  ATP+KLA
 NM_007648 CD3 antigen, epsilon polypeptide (Cd3e), mRNA [NM_007648] KLA 1.21 1.25 1.29 1.22 1.29 1.32 1.13
ATP .98 1.00 1.10 1.11 1.10 1.19 1.11
KLA/ATP 1.24 1.30 1.32 1.30 1.22 1.19 1.10
Cd4
KLA  ATP  ATP+KLA
 NM_013488 CD4 antigen (Cd4), mRNA [NM_013488] KLA .99 1.02 1.02 1.03 1.01 1.06 1.09
ATP 1.00 1.02 1.00 1.05 .96 .99 1.04
KLA/ATP 1.03 1.01 1.03 1.06 .97 .98 .98
Cd4
KLA  ATP  ATP+KLA
 X04836 gb|Mouse mRNA for T-cell surface glycoprotein CD4 (L3T4) [X04836] KLA .98 .91 .94 .96 .89 .92 1.03
ATP 1.11 1.07 1.02 .95 .90 .92 .88
KLA/ATP 1.04 1.00 1.01 .97 .90 1.02 .89
Cd40
KLA  ATP  ATP+KLA
 NM_170701 CD40 antigen (Cd40), transcript variant 3, mRNA [NM_170701] KLA 23.87 23.62 23.26 23.98 22.07 17.37 5.34
ATP 1.00 1.01 1.06 2.96 2.65 3.03 1.70
KLA/ATP 22.77 23.79 29.67 28.85 28.08 21.62 13.02
Cd40lg
KLA  ATP  ATP+KLA
 NM_011616 CD40 ligand (Cd40lg), mRNA [NM_011616] KLA 1.03 1.07 1.02 .98 1.06 1.06 1.03
ATP .95 .92 .99 1.06 1.02 1.04 1.07
KLA/ATP 1.00 1.01 .93 1.04 .94 1.01 .98
Cd79a
KLA  ATP  ATP+KLA
 NM_007655 CD79A antigen (immunoglobulin-associated alpha) (Cd79a), mRNA [NM_007655] KLA .96 1.05 .97 1.07 .97 1.05 .93
ATP .98 1.05 1.02 1.30 1.05 1.11 .96
KLA/ATP .97 1.00 1.08 1.12 1.06 1.06 1.04
Cd8a
KLA  ATP  ATP+KLA
 NM_001081110 CD8 antigen, alpha chain (Cd8a), mRNA [NM_001081110] KLA 1.02 1.03 1.04 1.04 1.07 1.03 1.02
ATP 1.01 .98 .99 1.03 1.01 1.00 .99
KLA/ATP 1.02 1.01 1.04 1.03 1.06 1.06 1.00
Cd8b1
KLA  ATP  ATP+KLA
 M17534 gb|Mouse T-cell membrane glycoprotein (Ly-3) mRNA, complete cds. [M17534] KLA 1.04 1.06 1.11 1.12 1.07 1.06 .95
ATP 1.00 1.07 .97 .97 .96 1.05 .98
KLA/ATP .96 1.02 1.07 1.03 1.05 .95 .97
Ciita
KLA  ATP  ATP+KLA
 NM_007575 class II transactivator (Ciita), mRNA [NM_007575] KLA 2.13 2.12 2.35 2.22 1.91 1.44 1.12
ATP 1.04 1.04 1.17 1.17 1.61 1.15 1.21
KLA/ATP 2.23 2.44 1.88 1.76 1.64 1.14 1.52
Dclre1c
KLA  ATP  ATP+KLA
 NM_146114 DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) (Dclre1c), transcript variant 1, mRNA [NM_146114] KLA 1.68 1.46 1.87 1.85 2.42 2.17 1.44
ATP 1.27 1.51 2.01 1.89 1.54 1.19 .92
KLA/ATP 1.83 1.78 2.18 2.18 2.20 1.96 2.29
Dclre1c
KLA  ATP  ATP+KLA
 NM_175683 DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) (Dclre1c), transcript variant 2, mRNA [NM_175683] KLA 1.53 1.60 1.78 1.77 2.20 2.56 1.37
ATP .91 .95 1.00 .93 .91 1.61 1.45
KLA/ATP 1.39 1.43 1.50 1.40 1.57 2.02 2.93
EG629860
KLA  ATP  ATP+KLA
 M17953 gb|Mouse Ig rearranged H-chain V-region mRNA VJ1 [M17953] KLA .96 1.05 1.03 1.08 1.08 1.02 .98
ATP .97 .99 1.05 1.10 .95 .94 .91
KLA/ATP .96 .94 .97 1.04 .97 1.01 .89
Icos
KLA  ATP  ATP+KLA
 AK030827 adult male thymus cDNA, RIKEN full-length enriched library, clone:5830414M16 product:inducible T-cell co-stimulator, full insert sequence [AK030827] KLA .99 .91 .97 .99 .94 .90 .78
ATP 1.06 .97 1.03 .88 .90 .91 .79
KLA/ATP .92 .99 .98 .97 .95 .90 .80
Icos
KLA  ATP  ATP+KLA
 NM_017480 inducible T-cell co-stimulator (Icos), mRNA [NM_017480] KLA 1.01 .96 .86 .95 .92 .91 .84
ATP .99 1.05 1.00 .98 .96 .97 .86
KLA/ATP .95 .98 .94 1.00 .96 .88 .87
Igh-VJ55
8
KLA  ATP  ATP+KLA
 AY547436 immunoglobulin heavy chain VDJ region mRNA, partial cds [AY547436] KLA 1.06 1.05 1.01 .93 1.03 .96 .93
ATP .99 1.00 1.06 .95 .96 1.06 1.05
KLA/ATP .98 .94 1.07 .95 .97 .99 1.02
Igh-VJ55
8
KLA  ATP  ATP+KLA
 CA578712 gb|K0727F04-5N NIA Mouse Hematopoietic Stem Cell (Lin- [CA578712] KLA .99 .94 1.01 1.10 .93 .97 .92
ATP .93 1.04 1.01 .98 1.05 .96 .95
KLA/ATP .99 .95 .95 .98 1.02 .98 .95
Igh-VJ55
8
KLA  ATP  ATP+KLA
 ENSMUST00000103412 ens|Immunoglobulin heavy chain C gene segment [Source:IMGT/GENE_DB;Acc:IGHA] [ENSMUST00000103412] KLA 1.01 .97 1.20 1.01 .98 1.44 1.24
ATP .99 .98 1.07 1.03 1.00 1.01 1.21
KLA/ATP .99 1.02 .96 1.03 .97 1.13 1.30
Igh-VJ55
8
KLA  ATP  ATP+KLA
 ENSMUST00000103413 ens|Immunoglobulin heavy chain C gene segment [Source:IMGT/GENE_DB;Acc:IGHE] [ENSMUST00000103413] KLA 1.00 .99 1.06 1.06 .99 1.03 1.02
ATP 1.08 1.06 1.06 1.06 1.02 1.06 .95
KLA/ATP 1.00 1.04 1.09 1.02 1.06 1.02 .95
Igh-VJ55
8
KLA  ATP  ATP+KLA
 U39781 J558+ IgM heavy chain mRNA, hybridoma clone ME2B7, partial cds. [U39781] KLA .93 .89 .98 .97 1.03 1.00 .94
ATP 1.04 1.02 1.08 .94 .93 .90 .79
KLA/ATP .88 .89 .97 .93 .88 .92 .82
Ikbkg
KLA  ATP  ATP+KLA
 AK042138 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630062P04 product:unclassifiable, full insert sequence. [AK042138] KLA .92 .87 .78 .78 .87 .88 .62
ATP .84 .71 .80 .50 1.15 2.33 .61
KLA/ATP .72 .69 .74 .48 1.06 1.97 .68
Ikbkg
KLA  ATP  ATP+KLA
 NM_010547 inhibitor of kappaB kinase gamma (Ikbkg), transcript variant 1, mRNA [NM_010547] KLA 1.51 1.63 1.74 1.83 1.83 1.73 1.72
ATP .80 .79 .82 .75 .66 2.58 2.37
KLA/ATP 1.43 1.42 1.17 1.04 .71 1.54 3.17
Ikbkg
KLA  ATP  ATP+KLA
 NM_178590 inhibitor of kappaB kinase gamma (Ikbkg), transcript variant 2, mRNA [NM_178590] KLA .84 .93 .86 .91 1.03 .89 .88
ATP 1.03 .98 .68 .56 .51 .93 .68
KLA/ATP .89 .81 .55 .52 .41 .67 .65
Il2rg
KLA  ATP  ATP+KLA
 NM_013563 interleukin 2 receptor, gamma chain (Il2rg), mRNA [NM_013563] KLA 2.97 2.92 3.73 3.39 4.04 3.45 4.83
ATP 1.25 1.41 1.04 1.82 1.48 1.12 2.89
KLA/ATP 3.65 4.34 2.42 4.70 2.62 2.54 5.15
Il7r
KLA  ATP  ATP+KLA
 AK041838 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630041A17 product:interleukin 7 receptor, full insert sequence. [AK041838] KLA .90 1.04 .92 .95 .90 1.05 .99
ATP .97 1.01 1.11 1.04 1.06 1.33 2.92
KLA/ATP .98 .97 .91 1.10 1.06 1.20 1.57
Il7r
KLA  ATP  ATP+KLA
 NM_008372 interleukin 7 receptor (Il7r), mRNA [NM_008372] KLA .42 .40 .37 .41 .36 .60 .73
ATP 1.02 1.01 1.23 1.13 1.72 2.94 7.90
KLA/ATP .40 .41 .53 .58 1.00 2.18 4.13
Jak3
KLA  ATP  ATP+KLA
 NM_010589 Janus kinase 3 (Jak3), mRNA [NM_010589] KLA 1.46 1.56 1.79 1.62 2.05 1.72 1.65
ATP 1.11 1.19 .84 1.25 .82 .61 .71
KLA/ATP 1.76 1.82 1.10 1.74 .93 .83 1.01
Lck
KLA  ATP  ATP+KLA
 NM_010693 lymphocyte protein tyrosine kinase (Lck), mRNA [NM_010693] KLA 18.74 17.97 23.64 20.20 17.34 8.29 1.29
ATP 1.00 1.04 1.28 1.30 1.48 2.55 1.44
KLA/ATP 21.76 24.22 23.73 23.04 22.66 12.06 2.90
Mm.1355
KLA  ATP  ATP+KLA
 142386539 Unknown KLA .98 1.05 .92 .96 .94 1.02 1.00
ATP 1.01 .99 1.02 1.34 1.15 1.01 1.09
KLA/ATP 1.03 1.02 .93 1.05 1.09 1.00 1.02
Mm.21036
1
KLA  ATP  ATP+KLA
 158508719 Unknown KLA 1.12 1.15 1.09 1.20 1.18 1.33 1.23
ATP 1.05 1.18 1.10 1.41 1.26 1.25 1.23
KLA/ATP 1.22 1.40 1.22 1.54 1.24 1.28 1.49
Mm.24004
7
KLA  ATP  ATP+KLA
 118130430 Unknown KLA 1.09 1.07 1.01 1.00 1.04 1.05 .97
ATP .98 1.00 1.05 .97 1.05 1.02 1.05
KLA/ATP .98 1.04 1.16 1.06 1.06 .96 1.02
Mm.33314
8
KLA  ATP  ATP+KLA
 118129874 Unknown KLA 1.04 1.03 1.05 1.08 1.05 1.02 1.00
ATP .95 1.08 .99 .91 .96 1.03 1.07
KLA/ATP .99 1.00 1.02 .98 1.00 .98 1.10
Mm.4988
KLA  ATP  ATP+KLA
 144227233 Unknown KLA .98 1.03 1.04 1.03 1.05 .90 1.03
ATP .99 1.00 1.04 1.00 1.01 .98 .99
KLA/ATP .98 1.12 .98 .98 .94 .99 .99
Orai1
KLA  ATP  ATP+KLA
 NM_175423 ORAI calcium release-activated calcium modulator 1 (Orai1), mRNA [NM_175423] KLA .54 .57 .51 .71 1.13 1.52 1.43
ATP 1.00 1.03 1.00 1.24 .85 1.56 1.87
KLA/ATP .56 .50 .50 .71 .77 1.26 2.53
Ptprc
KLA  ATP  ATP+KLA
 AK088215 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430007G18 product:protein tyrosine phosphatase, receptor type, C, full insert sequence. [AK088215] KLA 2.15 1.93 2.11 1.83 2.08 1.72 1.51
ATP .95 .84 .65 .50 1.79 .82 .77
KLA/ATP 2.01 1.68 1.50 .80 1.16 .73 1.14
Ptprc
KLA  ATP  ATP+KLA
 NM_011210 protein tyrosine phosphatase, receptor type, C (Ptprc), transcript variant 2, mRNA [NM_011210] KLA 2.06 2.00 2.21 2.29 2.20 1.90 1.86
ATP 1.02 .99 1.23 .82 1.01 1.68 .86
KLA/ATP 1.89 2.00 2.40 1.52 1.24 1.01 1.20
Rag1
KLA  ATP  ATP+KLA
 M29475 gb|Mouse recombination activating protein (RAG-1) mRNA, complete cds. [M29475] KLA .99 1.01 1.02 1.02 1.00 1.01 1.00
ATP 1.01 .97 1.02 1.00 1.00 1.00 1.01
KLA/ATP 1.01 1.01 1.00 1.03 1.00 1.01 1.01
Rag1
KLA  ATP  ATP+KLA
 NM_009019 recombination activating gene 1 (Rag1), mRNA [NM_009019] KLA 1.04 1.02 .99 1.01 1.00 1.04 1.02
ATP .98 1.01 .98 1.03 1.06 1.04 .99
KLA/ATP 1.00 1.03 .93 1.03 1.08 1.06 .99
Rag2
KLA  ATP  ATP+KLA
 NM_009020 recombination activating gene 2 (Rag2), mRNA [NM_009020] KLA 1.01 1.02 1.02 1.03 1.01 1.01 1.01
ATP .99 1.00 1.01 1.01 1.01 1.03 1.02
KLA/ATP .99 .98 1.01 1.02 1.01 1.03 1.01
Rfx5
KLA  ATP  ATP+KLA
 NM_017395 regulatory factor X, 5 (influences HLA class II expression) (Rfx5), mRNA [NM_017395] KLA 1.30 1.30 1.30 1.19 1.33 1.22 1.02
ATP 1.08 1.09 1.02 .98 .86 .96 .89
KLA/ATP 1.44 1.38 1.15 1.07 .86 1.07 1.06
Rfxank
KLA  ATP  ATP+KLA
 NM_011266 regulatory factor X-associated ankyrin-containing protein (Rfxank), transcript variant 1, mRNA [NM_011266] KLA .91 .87 .99 1.00 1.17 1.44 1.74
ATP 1.10 1.02 .95 1.29 .98 1.18 2.64
KLA/ATP 1.04 .94 .90 1.01 .93 1.33 3.07
Rfxap
KLA  ATP  ATP+KLA
 NM_133231 regulatory factor X-associated protein (Rfxap), mRNA [NM_133231] KLA .60 .59 .59 .59 .62 .77 .83
ATP .95 .93 .68 .64 1.01 1.02 .96
KLA/ATP .61 .57 .52 .55 .93 1.11 1.03
Tap1
KLA  ATP  ATP+KLA
 NM_013683 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (Tap1), mRNA [NM_013683] KLA 7.60 7.62 9.05 9.01 9.36 8.57 4.96
ATP 1.00 1.07 .96 1.13 .74 2.83 2.43
KLA/ATP 7.99 8.80 8.37 9.52 7.44 8.61 9.95
Tap2
KLA  ATP  ATP+KLA
 NM_011530 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (Tap2), mRNA [NM_011530] KLA 4.36 4.80 4.71 5.53 4.94 5.09 2.85
ATP .93 1.12 .97 1.20 1.38 2.30 2.20
KLA/ATP 4.15 5.22 6.03 6.07 5.60 5.42 6.52
Tnfrsf13
b
KLA  ATP  ATP+KLA
 AK155178 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630206K19 product:tumor necrosis factor receptor superfamily, member 13b, full insert sequence [AK155178] KLA .49 .51 .50 .49 .55 .72 .66
ATP 1.01 1.08 1.16 1.27 .78 .28 .69
KLA/ATP .50 .54 .52 .54 .35 .28 .64
Tnfrsf13
b
KLA  ATP  ATP+KLA
 NM_021349 tumor necrosis factor receptor superfamily, member 13b (Tnfrsf13b), mRNA [NM_021349] KLA .85 .87 .83 .83 .89 .90 .90
ATP .96 .96 1.00 .98 .80 .75 .91
KLA/ATP .85 .87 .84 .88 .77 .84 .87
Tnfrsf13
c
KLA  ATP  ATP+KLA
 NM_028075 tumor necrosis factor receptor superfamily, member 13c (Tnfrsf13c), mRNA [NM_028075] KLA 1.05 1.04 1.05 1.01 1.05 1.00 .92
ATP 1.03 1.01 1.01 .99 1.04 1.03 1.04
KLA/ATP 1.05 1.07 1.10 1.04 1.02 .94 1.00
Ung
KLA  ATP  ATP+KLA
 NM_001040691 uracil DNA glycosylase (Ung), transcript variant 1, mRNA [NM_001040691] KLA .19 .17 .17 .16 .16 .24 .18
ATP .87 .83 1.06 .77 .42 .23 .26
KLA/ATP .16 .17 .23 .22 .27 .25 .15
Zap70
KLA  ATP  ATP+KLA
 NM_009539 zeta-chain (TCR) associated protein kinase (Zap70), mRNA [NM_009539] KLA .94 .88 .84 .86 1.01 .92 .94
ATP 1.02 .99 .87 .87 1.58 .98 .96
KLA/ATP .94 .82 .83 .77 1.09 .93 1.02