LMPD Database

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LMP000943

UniProt Annotations

Entry Information
Gene NameATPase, class V, type 10A
Protein EntryAT10A_MOUSE
UniProt IDO54827
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
FunctionCatalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). {ECO:0000250}.
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A. {ECO:0000250}.
SubunitComponent of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. {ECO:0000250}.
Tissue SpecificityFound in testis and in white adipose tissue. Also detected in fetal tissues. {ECO:0000269|PubMed:11074018}.