LMPD Database


UniProt Annotations

Entry Information
Gene Namecholine kinase beta
Protein EntryCHKB_HUMAN
UniProt IDQ9Y259
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y259-1; Sequence=Displayed; Name=2; IsoId=Q9Y259-2; Sequence=VSP_034248, VSP_034249;
Biophysicochemical PropertiesKinetic parameters: KM=0.57 mM for choline ; KM=2.9 mM for ethanolamine ;
Catalytic ActivityATP + choline = ADP + phosphocholine.
Catalytic ActivityATP + ethanolamine = ADP + O- phosphoethanolamine.
FunctionHas a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.
MiscellaneousThis protein is produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame.
PathwayPhospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
Sequence CautionSequence=AAB03342.2; Type=Erroneous gene model prediction; Evidence= ;
SimilarityBelongs to the choline/ethanolamine kinase family.
SubunitHomodimer, and heterodimer with CHKA.