LMPD Database

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LMP004118

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC-type containing 7
Protein EntryZDHC7_HUMAN
UniProt IDQ9NXF8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NXF8-1; Sequence=Displayed; Name=2; IsoId=Q9NXF8-2; Sequence=VSP_006942;
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionPalmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors.
Sequence CautionSequence=AAH17702.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAA91814.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the DHHC palmitoyltransferase family.
SimilarityContains 1 DHHC-type zinc finger.
Subcellular LocationMembrane ; Multi-pass membrane protein . Golgi apparatus .