LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006553

UniProt Annotations

Entry Information
Gene NameELOVL family member 6, elongation of long chain fatty acids (yeast)
Protein EntryELOV6_MOUSE
UniProt IDQ920L5
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
FunctionCondensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Elongates fatty acids with C12, 14 and 16 carbons. {ECO:0000269|PubMed:11567032, ECO:0000269|PubMed:12032166}.
InductionBy SREBF1. {ECO:0000269|PubMed:11567032, ECO:0000269|PubMed:12032166}.
SimilarityBelongs to the ELO family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityHighly expressed in adrenal gland, liver, white adipose tissue (WAT), adult and fetal brain, cerebellum, spinal cord, testis, skin and peripheral nerve; where lipogenesis and steroidogenesis are active. Weakly expressed in kidney, heart, skeletal muscle, lung, and spleen. {ECO:0000269|PubMed:11567032, ECO:0000269|PubMed:12032166, ECO:0000269|PubMed:12084938}.