LMPD Database

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LMP006697

UniProt Annotations

Entry Information
Gene Namesterile alpha motif domain containing 8
Protein EntryQ96LT4_HUMAN
UniProt IDQ96LT4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96LT4-1; Sequence=Displayed; Name=2; IsoId=Q96LT4-2; Sequence=VSP_038403, VSP_038404;
DomainThe SAM domain is required to retain SMAD8 in the endoplasmic reticulum.
FunctionSphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
Sequence CautionSequence=AAH80593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityBelongs to the sphingomyelin synthase family.
SimilarityContains 1 SAM (sterile alpha motif) domain.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .