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LMP006713

Record overview

LMPD IDLMP006713
Gene ID158833
SpeciesHomo sapiens (Human)
Gene Nameacyl-CoA wax alcohol acyltransferase 1
Gene SymbolAWAT1
SynonymsDGA2; DGAT2L3
Alternate namesacyl-CoA wax alcohol acyltransferase 1; diacylglycerol acyltransferase 2; diacyl-glycerol acyltransferase 2; diacylglycerol O-acyltransferase 2-like 3; long-chain-alcohol O-fatty-acyltransferase 1; diacylglycerol O-acyltransferase 2-like protein 3
ChromosomeX
Map LocationXq13.1
EC Number2.3.1.75
SummaryThe protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
OrthologsView orthologs and multiple alignments for AWAT1

Proteins

acyl-CoA wax alcohol acyltransferase 1
Refseq ID:NP_001013597
Protein GI:61888902
UniProt ID:Q58HT5
mRNA ID:NM_001013579
Length:328
RefSeq Status:REVIEWED
MAHSKQPSHFQSLMLLQWPLSYLAIFWILQPLFVYLLFTSLWPLPVLYFAWLFLDWKTPERGGRRSAWVRNWCVWTHIRDYFPITILKTKDLSPEHNYLM
GVHPHGLLTFGAFCNFCTEATGFSKTFPGITPHLATLSWFFKIPFVREYLMAKGVCSVSQPAINYLLSHGTGNLVGIVVGGVGEALQSVPNTTTLILQKR
KGFVRTALQHGAHLVPTFTFGETEVYDQVLFHKDSRMYKFQSCFRRIFGFYCCVFYGQSFCQGSTGLLPYSRPIVTVVGEPLPLPQIEKPSQEMVDKYHA
LYMDALHKLFDQHKTHYGCSETQKLFFL