LMPD Database

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LMP006733

UniProt Annotations

Entry Information
Gene Nameceramide-1-phosphate transfer protein
Protein EntryCPTP_HUMAN
UniProt IDQ5TA50
SpeciesHuman
Comments
Comment typeDescription
FunctionMediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide.
Sequence CautionSequence=EAW56230.1; Type=Erroneous gene model prediction; Evidence= ;
SimilarityBelongs to the GLTP family.
Subcellular LocationCytoplasm, cytosol . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein . Nucleus outer membrane ; Peripheral membrane protein .
Tissue SpecificityUbiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.