LMPD Database

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LMP006751

Record overview

LMPD IDLMP006751
Gene ID51141
SpeciesHomo sapiens (Human)
Gene Nameinsulin induced gene 2
Gene SymbolINSIG2
Synonyms-
Alternate namesinsulin-induced gene 2 protein; INSIG-2; INSIG2 membrane protein; insulin induced protein 2
Chromosome2
Map Location2q14.2
SummaryThe protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for INSIG2

Proteins

insulin-induced gene 2 protein
Refseq ID:NP_057217
Protein GI:38327533
UniProt ID:Q9Y5U4
mRNA ID:NM_016133
Length:225
RefSeq Status:REVIEWED
MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHK
FKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGG
ITMGNIGRQLAMYECKVIAEKSHQE