LMPD Database

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LMP006932

UniProt Annotations

Entry Information
Gene Namesuccinate dehydrogenase iron-sulfur protein subunit SDH2
Protein EntrySDHB_YEAST
UniProt IDP21801
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivitySuccinate + a quinone = fumarate + a quinol.
CofactorName=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000250}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CofactorName=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence={ECO:0000250}; Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
CofactorName=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250}; Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
FunctionSubunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.
MiscellaneousPresent with 9540 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayCarbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
SimilarityBelongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. {ECO:0000305}.
SimilarityContains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00465}.
SimilarityContains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00711}.
Subcellular LocationMitochondrion inner membrane; Peripheral membrane protein; Matrix side.
SubunitComponent of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. {ECO:0000250}.