LMPD Database

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LMP006940

UniProt Annotations

Entry Information
Gene Namesphingosine N-acyltransferase LAG1
Protein EntryLAG1_YEAST
UniProt IDP38703
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + sphingosine = CoA + N- acylsphingosine.
FunctionComponent of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span. {ECO:0000269|PubMed:10198056, ECO:0000269|PubMed:11387200, ECO:0000269|PubMed:11694577, ECO:0000269|PubMed:15236759, ECO:0000269|PubMed:15692566}.
InductionExpression is controlled by CBF1
InductionExpression is controlled by CBF1. {ECO:0000269|PubMed:15302821}.
InteractionP28496:LAC1; NbExp=7; IntAct=EBI-10035, EBI-26585; Q03579:LIP1; NbExp=4; IntAct=EBI-10035, EBI-27640;
SimilarityBelongs to the sphingosine N-acyltransferase family
SimilarityBelongs to the sphingosine N-acyltransferase family. {ECO:0000305}.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.